ESTROBALANCE - ESTROGEN METABOLITES

Test Reactivation. Profile Composition, Method and Reference Values Modification

Test code: 4754
Mnemonic code: MESO

Effective update from 21/10/2024

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Method: Enzyme Immunoassay    Reference Values (*):     2-OH estrone + 2-OH estradiol:   Follicular Phase  : 3.4 - 22.8 ng/mg creat.   Ovulatory Phase   : 4.0 - 43.4 ng/mg creat.   Luteal Phase      : 7.9 - 28.5 ng/mg creat.   Postmenopause     : 3.5 - 7.5 ng/mg creat.   With TSH treatment: 0.3 - 76.1 ng/mg creat.   16-alpha-OH estrone   Follicular Phase  : 1.3 - 18.2 ng/mg creat.   Ovulatory Phase   : 4.7 - 25.7 ng/mg creat.   Luteal Phase      : 4.6 - 24.2 ng/mg creat.   Postmenopause     : 2.0 - 5.8 ng/mg creat.   With TSH treatment: 3.4 - 21.2 ng/mg creat.   2/16 RATIO:   Follicular Phase  : 0.7 - 2.61   Ovulatory Phase   : 0.9 - 2.44   Luteal Phase      : 0.68 - 2.22   Postmenopause     : 1.12 - 1.94   With TSH treatment: 1.25 - 4.25   Optimal value for premenopause and postmenopause: > 2 (*)Reference values indicated in the attached report       Version of Test: 16

Method: LC-MS/MS   Reference Values (*):   2-OH estrone:   Women < 55 years: 0.4 – 42.8 ng/mg creat.   Women > 55 years: 0.6 – 4.2 ng/mg creat.   Men             : 0.2 – 6.4 ng/mg creat.   16-alpha-OH estrone   Women < 55 years: 0.3 – 20.5 ng/mg creat.   Women > 55 years: 0.1 – 1.6 ng/mg creat.   Men             : 0.2 – 3.4 ng/mg creat.   2/16 RATIO:   Women < 55 years: > 0.3   Women > 55 years: > 1.9   Men             : > 0.3 (*) Reference values indicated in the attached reportS        Version of Test: 17

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Light Chains Neurofilaments, Serum

Description, Sample, Sample Conservation, Method and Reference values Modification

Test code: 8745

Mnemonic code: NFLSU

Effective update from 28/10/2024

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Description: LIGHT CHAINS NEUROFILAMENTS, SERUM  Sample: Refrigerated serum  Method: Single Molecular Array (SIMOA)  Reference Values:  < 30 years: Less than 9.9 pg/mL  30 - 50 years: Less than 17.5 pg/mL  51 - 60 years: Less than 23.3 pg/mL  61 - 70 years: Less than 30.9 pg/mL  71 - 80 years: Less than 41.3 pg/mL  > 81 years: Less than 54.9 pg/mL                   Version of Test: 7

Description: LIGHT CHAINS NEUROFILAMENTS, PLASMA  Sample: Frozen Plasma-EDTA (14 days stability) *Pre-analytical protocol: After sample collection, centrifuge within 3 hours if the sample is kept at room temperature, or within 24 hours if refrigerated (2-10°C). Transfer the plasma to a polypropylene tube and freeze immediately. Send frozen.  Method: Chemiluminescence    Reference Values:   18-29 years: Less than 9.4 pg/mL  30-39 years: Less than 9.6 pg/mL  40-49 years: Less than 13.3 pg/mL  50-59 years: Less than 21.2 pg/mL  60-69 years: Less than 28.1 pg/mL  70-90 years: Less than 46.8 pg/mL  *Source: Insert - Bibliography Simrén J, et al. Brain Communications 2022    Version of Test: 8

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Light Chains Neurofilaments, CSF

Sample Conservatopm. Method, Reference values and Delivery Time Modification

Test code: 8746
Mnemonic code:  NFLLC

Effective update from 28/10/2024

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Sample Conservation: Refrigerated CSF  Method: Enzyme Immunoassay   Reference Values:  < 30 years: Less than 289 pg/mL  31 - 40 years: Less than 379 pg/mL  > 41 years: Less than 829 pg/mL        Delivery Time: 19 days       Version of Test: 8	Sample Conservation: Frozen CSF (2 months stability)  *Send it in polypropylene tube  Method: Chemiluminescence  Reference Values:  Under 30 years: Less than 380 pg/mL  30-39 years: Less than 560 pg/mL  40-59 years: Less than 890 pg/mL  60 years or older: Less than 1850 pg/mL  *Source: Insert  Delivery Time: 12 days       Version of Test: 9

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FACTOR II TUMORAL NECROSIS (TNF- alfa) , SERUM

Test Reactivation. Method, Reference values and Delivery Time Modification

Test code: 2262

Mnemonic code: TNFA

Effective update from 28/10/2024

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Method: Enzyme Immunoassay        Reference Values:       4.6 pg/mL - 12.4 pg/mL       * Source: PNT, Insert             Delivery term: 7 days                   Version of Test: 11	Method: Chemiluminescence                                Reference Values:       Less than or equal to 13.7 pg/mL       *Source: Insert         Delivery term: 5 days                   Version of Test: 12

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LIGHT CHAINS KAPPA/LAMBDA, URINE

Test Reactivation. Result Format, Method, References Values and Delivery Time Modification

Test code: 2063
Mnemonic code: QCLO

Effective update from 23/10/2024

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Method: Nephelometry   Result Format:  Light Chains KAPPA : R1 mg/L  Light Chains LAMBDA : R2 mg/L  RATIO KAPPA/LAMBDA : R3   Reference Values  Light Chains KAPPA : < 7 mg/L  Light Chains LAMBDA : < 5 mg/L  RATIO KAPPA/LAMBDA : 0.75 - 4.5  *Source: Insert  Delivery Time: 1 day              Version of Test: 10	Method: Turbidimetry             Result Format:  Light Chains KAPPA : R1 mg/L  Light Chains LAMBDA : R2 mg/L  Reference Values  Light Chains KAPPA : Less than 9 mg/L  Light Chains LAMBDA : Less than 7 mg/L  *Source: Insert  Delivery Time: 3 days                Version of Test: 11

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VASCULAR ENDOTHELIAL GROWTH FACTOR TYPE A (VEGF-A), PLASMA

Test Reactivation

Test code: 1232
Mnemonic code: VEGF

Effective update from 21/10/2024

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LIGHT CHAINS KAPPA/LAMBDA- SERUM

Test Reactivation. Method Modification

Test code: 2062
Mnemonic code: QCLS

Effective update from 18/10/2024

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Method: Nephelometry                     Version of Test: 6	Method: Turbidimetry                              Version of Test: 7

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