TRICHLOROACETIC ACID (METABOLITES OF PERCHLORETHYLENE AND/OR TRICHLORETHYLENE), URINE

Description, Sample, Method and Reference values Modification

Test code: 883
Mnemonic code: Does not apply

Effective update from 10/06/2024

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Description: TRICHLOROACETIC ACID (METABOLITES OF PERCHLORETHYLENE AND/OR TRICHLORETHYLENE), URINE Sample: URINE Method: High Performance Liquid Chromatography Reference Values People exposed to PERCHLOROETHYLENE FJL (At the end of the workweek): Up to 3.5 mg/L People exposed to trichlorethylene FJL (At the end of the workweek): Up to 15.0 mg/L * Fuente: Valores Bibliograficos                             Version of Test: 4

Description: TRICHLOROACETIC ACID, URINE Sample: END WORKING DAY URINE Method: Gas Chromatography/Electron Capture Detector (ECD) Reference Values VLB (INSST) at the end of the working day: Less than 15 mg/L BEI (ACGIH) at the end of the working day: Less than 15 mg/L Limit of quantification: Lees than 1 mg/L     Version of Test: 5

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MYELIN BASIC PROTEIN , CSF

Reference values Modification

Test code: 2004
Mnemonic code: PBMI

Effective update from 10/06/2024

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Less than 4.0 ng/mL                   Version of Test: 2	Less than 5.5 ng/mL                          Version of Test: 3

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VARICELLA ZOSTER IgA ANTIBODIES, SERUM

Test reactivation

Test code: 7662
Mnemonic code: VZA

Effective update from 30/05/2024

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VARICELLA ZOSTER IgG and IgM ANTIBODIES, CSF

Tests Reactivation

Test code: 4275, 4276

Mnemonic code: VZMCR, VZGCR

Effective update from 30/05/2024

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FREE PHENYTOIN, SERUM

Method Modification

Test code: 1930
Mnemonic code: FENLISU

Effective update from 10/06/2024

PREVIOUS	NEW
High Performance Liquid Chromatography (HPLC)                   Version of Test: 12	Liquid Chromatography/Mass Spectrometry (LCMS)                Version of Test: 13

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Furosemide, serum

Method Modification

Test code: 3480

Mnemonic code: FUROS

Effective update from 10/06/2024

PREVIOUS	NEW
High Performance Liquid Chromatography (HPLC)                    Version of Test: 3	Liquid Chromatography/Mass Spectrometry (LCMS)                         Version of Test: 4

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HLA-B5701 genotype (susceptibility to Abacavir), total blood

Description, Method, Result Format and Reference values Modification

Test code: 3467
Mnemonic code: B5701

Effective update from 10/06/2024

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Description: HLA-B5701 genotype (susceptibility to Abacavir), total blood Method: Real-Time PCR Result format:  R1  Result Reference Values: Negative Technique: DNA extraction from whole blood and subsequent amplification by real-time PCR (CE-IVD commercial method) of the alleles of the HLA-B*57:01 group associated with a hypersensitivity reaction to abacavir, and of a fragment of the HBB (ß-globin) gene used as an internal positive control. Version of Test: 4

Description: B5701 (HLA-B*57:01 ALLELE), WHOLE BLOOD Method: Multiplex PCR/Real-Time PCR Result format:  R1  Sample                 R2  Result Reference Values: Interpretation Abacavir is a drug that is generally used in combination with others to treat HIV infection. It acts as a reverse transcriptase inhibitor and, although it may present side effects, it is generally well tolerated. However, serious hypersensitivity reactions with symptoms of liver damage and lactic acidosis, which can be life-threatening, have been reported. Hypersensitivity to abacavir is strongly associated with HLA-B*57:01 allele, an HLA-B gene polymorphism present in around 3% of European population. Consequently, it is recommended to determine the presence/absence of this allele prior to starting treatment since abacavir hypersensitivity is prone to late diagnosis, when symptoms have already appeared, and treatment is more torpid. This report should be evaluated by a specialist in the context of all available clinical and family information in conjunction with other laboratory findings. Genetic counselling is recommended. Test method DNA extraction followed by real-time PCR amplification (CE-IVD commercial method) of  HLA-B*57:01 allele group, associated with abacavir hypersensitivity reaction, and of an HBB gene fragment (β-globin) as internal positive control Test limitations Variants other than those studied are not analyzed. Normal/polymorphic genomic variation in the patient may interfere with variant detection in the sample. References Cameron P. U. et al. Abacavir. (2021). Kucers’ the Use of Antibiotics. Seventh Edition 3773–3800  Mallal, S. et al. (2002). The Lancet 359, 727–732  Saag, M. S. et al. (2008). Clinical Infectious Diseases 46, 1111–1118  Quiros-Roldan, E. et al. (2020). Pharmacogenetics and Genomics 167–174  Mallal, S. et al. (2008). N Engl J Med 358, 568–579 Version of Test: 5

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WILMS TUMOR · WT1 · MLPA

New Test in NOÛS Catalog

Test Code: 10053

Sample:	Whole blood - EDTA (5 ml)
Conservation:	Refrigerated
Method:	Multiplex Ligation-dependent Probe Amplification-MLPA
Set Up Days:	Daily
Delivery term:	22 days

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LINK INDEX PARAMETERS

Description, Report and Reference values Modification

Test code: 3190

Mnemonic code: Does not apply

Effective update from 10/06/2024

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LINK INDEX PARAMETERS R1- IgG CSF R2- Albumin serum R3- IgG serum R4- Albumin CSF          IgG CSF: Less than 3.40 mg/dL Albumin Serum: 35.00 - 52.00 g/L IgG Serum: 295.00 - 1719.00 mg/dL Albumin CSF: Less than 35.00 mg/dL Link Index: Less than 0.80                   Version of Test: 8	TIBBLING-LINK INDEX R1- IgG serum R2- Albumin serum R3- IgG CSF R4- Albumin CSF IgG Serum:      295.00 - 1719.00 mg/dL Albumin Serum:  35.00 - 52.00 g/L   IgG CSF:        Less than 3.40 mg/dL Albumin CSF:    Less than 35.00 mg/dL Link Index:     Less than 0.80                   Version of Test: 9

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OROPOUCHE ANTIBODIES IgG + IgM, SERUM

New Test in NOÛS Catalog

Test Code: 10052

Sample:	Serum (1 ml)
Conservation:	Refrigerated
Method:	Indirect fluorescent antibody
Set Up Days:	Daily
Delivery term:	15 days

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BIOTINIDASE ACTIVITY, PLASMA

Reference values Modification

Test code: 2709
Mnemonic code: BIOT

Effective update from 10/06/2024

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5.3 - 12.2 nmol/mL/min       LoQ: 0.5 nmol/mL/min                   Version of Test: 14	7.8 – 13.1 nmol/mL/min                                    Version of Test: 15

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BARTONELLA (Rochalimaea) HENSELAE(CAT SCRATCH FEVER) IgM ANTIBODIES, SERUM

Test reactivation and Reference values Modification

Test code: 2498
Mnemonic code: BAHM

Effective update from 10/06/2024

PREVIOUS	NEW
Negative: Titer less than 1/5.       *Source: Insert             Version of Test: 7	Negative: Titer less than 1/12          *Source: Insert                  Version of Test: 8

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BARTONELLA HENSELAE (Rochalimaea) (CAT SCRATCH FEVER) ANTIBODIES, SERUM

Test reactivation and Reference values Modification

Test code: 2497

Mnemonic code: BAHG

Effective update from 10/06/2024

PREVIOUS	NEW
Negative: Titer less than 1/100       *Source: Insert             Version of Test: 7	Negative: Titer less than 1/512          *Source: Insert                Version of Test: 8

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DICHLOROMETHANE, URINE

Reference values Modification

Test code: 6004
Mnemonic code: DICL

Effective update from 03/06/2024

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Non-exposed personnel: Less than 0.3 mg/L                    Version of Test: 6	Exposure to Dichloromethane   VLB (INSST) in end-of-shift urine: Less than 0.3 mg/L   BEI (ACGIH) in end-of-shift urine: Less than 0.3 mg/L      Limit of Quantification: Less than 0.05 mg/L         Version of Test: 7

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PORPHYRINS , URINE

Reference values Modification

Test code: 5194
Mnemonic code: PFRA

Effective update from 10/06/2024

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COPROPORPHYRINS I : Less than 25 µg/24H       COPROPORPHYRINS III : Less than 75 µg/24H       UROPORPHYRINS (OCTOCARBOXYL) : Less than 25 µg/24H       PENTACARBOXYLPORPHYRINS : Less than 5 µg/24H       HEXACARBOXYLPORPHYRINS : Less than 2 µg/24H       HEPTACARBOXYLPORPHYRINS : Less than 5 µg/24H                       Version of Test: 6

COPROPORPHYRIN I  : 2 - 24 µg/24H     COPROPORPHYRIN III: 10 - 65 µg/24H     UROPORPHYRINS (OCTOCARBOXYL): 3 - 24 µg/24H     PENTACARBOXYLPORPHYRINS: Less than 4 µg/24H     HEXACARBOXYLPORPHYRINS: Less than 2 µg/24H     HEPTACARBOXYLPORPHYRINS: Less than 3 µg/24H     *Source: Thomas L: Labor & Diagnose 2020,2020. www.labor-und-diagnose-2020.de, accessed October 14, 2021.                                              Version of Test: 7

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