ALPHA-TALASEMIA MOLECULAR STUDY - MLPA

Description and Delivery Time Modification

Test code: 7800

Effective update from 03/02/2020

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ALPHA-TALASEMIA MOLECULAR STUDY - MLPA Delivery Term: 30 days                   Version of Test: 42	ALPHA TALASEMIA · HBA1, HBA2 · MLPA Delivery Term: 22 days                      Version of Test: 43

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Glycogenosis, panel (22 genes) NGS, whole blood

Description, Studied Genes and Delivery Time Modification

Test code: 4759

Effective update from 03/02/2020

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Glycogenosis, panel (22 genes) NGS, whole blood         Studied Genes: GYS1, GYS2, G6PC, SLC37A4, GAA, LAMP2,  AGL, GBE1, PYGM, PYGL, PFKM, PHKA2, PHKB, PHKG2, PGAM2, LDHA, ALDOA, ENO3, PGM1, GYG1, PHKA1, PRKAG2      Delivery Term: 65 days             Version of Test: 3	GLYCOGENOSIS · PANEL · NGS          Studied Genes: AGL, ALDOA, ALDOB, ENO3, FBP1, G6PC, GAA, GBE1, GYG1, GYS1, GYS2, LAMP2, LDHA, PFKM, PGAM2, PGK1, PGM1, PHKA1, PHKA2, PHKB, PHKG2, PRKAG2, PRKAG3, PYGL, PYGM, SLC2A2, SLC37A4         Delivery Term: 42 days       Version of Test: 4

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Entamoeba histolytica DNA, faeces/exudate

Reference values Modification

Test code: 1900

Effective update from 03/02/2020

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NEGATIVE                   Version of Test: 5	Not detected                          Version of Test: 6

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BREAST/OVARIAN CANCER · BRCA1, BRCA2 · NGS

Description Modification

Test code: 8188

Effective update from 31/01/2020

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BREAST/OVARIAN CANCER · BRCA1, BRCA2 · NGS	BIOMARKERS IN SOLID TUMORS · BRCA1, BRCA2 · NGS

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Protein electrophoresis, urine

Report Modification

Test code: 4676

Effective update from 29/01/2020

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R1. Interpretation  R2. Total Proteins  R3. Total Proteins 24h	R1. Interpretation R2. Total Proteins R3. Total Proteins (24h urine) R4. Albumin (%) R5. Alpha-1 globulin (%) R6. Alpha-2 globulin (%) R7. Beta globulin (%) R8. Gamma globulin (%)       R9. Globulins (%)

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Dermatomyositis - myositis (MDA5,TIF1,NXP2,SAE1,KU,MI2a, MI2b, PL12,PL7,SRP PM-Scl100.PM-Scl75, JO1,EJ,OJ,RO52) Antibodies. Serum

Delivery Time Modification

Test code: 5522

Effective update from 03/02/2020

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Delivery term: 32 days	Delivery term: 5 days

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IMMUNOGLOBULIN IgE-SPECIFIC IMMUNE CHIP SOLID PHASE - (ISAC) (ALLERGEN PROFILE WIDE RANGE A MOLECULAR LEVEL), SERUM

Temporarily Discontinued Test

Test code: 4215

Effective update from 31/01/2020

Due to shortage of the reagent by the manufacturer (ThermoFisher) and alterations in the reagents supply for ISAC - 112 Recombinant Allergens Microarray Study,  the test will be temporarily discontinued.

Our supplier has informed us of the problems in the production capacity. This limitation may alter the supply of reagents to our Central Laboratory in Barcelona, which could lead to delays in the results delivery time.

We will keep you posted on any further update from ThermoFisher.

We are at your disposal and service for any clarification.

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ISOMERS PORPHYRINS, WHOLE BLOOD

Report, Reference values Modification

Test code: 3831

Effective update from 29/01/2020

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Reference values: Attached report.       Reference values: See attached report.             Version of Test: 15

Res1. Protoporphyrin whole blood (µmol/LH) Res2. Plasma fluorescence (qulitative) Res3. Total porphyrin (nmol/L)   Res4. Fractionated porphyrin                                Reference values:       Protoporphyrin whole blood: Less than 2.5 µmol/LH*       Plasma fluorescence: Negative       Total porphyrin: Less than 50 nmol/L       *Protoporphyrin units in blood at micromol/liter red blood cells (µmol/LH, less than 2.5), according to the recommendations of the EPNET European Porphyria Network.       Version of Test: 16

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COCLEARS P-68 ANTIBODIES, SERUM

Description Modification

Test code: 7740

Effective update from 31/01/2020

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COCLEARS P-68 ANTIBODIES, SERUM	COCLEARS P-68 kD (HSP-70) ANTIBODIES, SERUM

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APOLIPOPROTEIN RATIO B/A1, SERUM

New Test in Catalog

Test Code: 8453

Sample:	Serum (1 ml)
Conservation:	Refrigerated
Method:	Nephelometry
Set Up Days:	Daily
Delivery term:	2 days

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Discontinuity Thermofisher Allergen-Specific IgE stock date on 31/01/2020

Due to discontinuity of ThermoFisher reagent, the reagents of the following specific IgE allergens will be discontinued at the end of January:

SYNLAB CODE	Allergen-Specific IgE
671	c70 - Insulin (pork)
672	c71 – Insulin (bovine)
6112	c209 - Chymopapain
2948	e205 – Horse Serum Proteins
3181	e210 – Epithelium Fox
3427	f292 – Guava
4880	f295 - Averrhoa carambola
2947	f331 – Saffron
3448	f348 – Lichi
5599	g203 – Salt grass
3885	g204 – Arrhenatherum elatius
659	k71 – Castor Bean
2527	k212 –  ABACHI - Sawdust Triphochiton scteroxylon
2517	o202 – Artemisia salina
2353	o207 – Daphnia (Fish Food)
6104	w210 -Beet

SYNLAB Barcelona will continue performing these tests while it has ThermoFisher reagent. In order to be able to guarantee the continuity of the service, we have planned alternative procedures with documented technical solvency, which will only entail a change in methodology and will guarantee the maintenance of the reference values. The changes made will be communicated progressively according to the implementation of the new procedures.

If considered appropiate, do not hesitate to contact us for more information.

URIC ACID , SERUM

Reference values Modification

Test code: 776

Effective update from 03/02/2020

We inform you that after an exhaustive review on the suitability of the biological reference intervals of serum Uric Acid, it has been decided by the technical management of the laboratory to make an adjustment according to the measurement procedure used, whose sole purpose is a correct interpretation by laboratory users of the results obtained for this biological magnitude.

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Male   : 4.2 - 8   mg/dL       Females: 3.5 - 7.3 mg/dL	Male   : 3.6 - 7.7 mg/dL       Females: 2.6 - 6.8 mg/dL

This change will be effective as of Monday, February 3.

For any questions or comments about the change of reference limits, please contact us. 

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Mycoplasma genitalium DNA, biological sample

Reference values Modification

Test code: 4837

Effective update from 27/01/2020

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NEGATIVE	Not detected.

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Technical Incident: IMMUNOFIXATION/ELECTROPHORESIS GRAPHS

Dear colleagues and collaborators,

The purpose of this letter is to notify you of the technical incident that occurred in the Central Laboratory of Barcelona and has affected the graphs generator equipment of the following tests:

  226- PROTEIN ELECTROPHORESIS, CSF
4676- Protein electrophoresis, urine
  702- PROTEIN ELECTROPHORESIS, URINE
2450- IMMUNOFIXATION,  SERUM
2449- IMMUNOFIXATION, URINE

From yesterday, January 22, images cannot be attached in the cited tests and has caused delay in the delivery of results.
The final solution may involve some change in the format of these graphics, although work is being done to find a technical solution as soon as possible. 
If this were the case, we will previously communicate it, with its corresponding specifications.
We deeply regret the inconvenience that this situation may generate, and we ask you to transfer our most sincere apologies to your clients as well as the sense of urgency and preference given to solve this situation.

We remain at your disposal for any clarification on the matter.

ONCO IN BLOOD EML4-ALK and ONCO IN BLOOD MET (splicing variants 7/8 and 14)

Sample Type Modification

Test code: 7356; 7365

Effective update from 24/01/2020

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SERUM + PLASMA EDTA 3mL 2 ml of serum and 2 ml of plasma. Centrifuge and transfer to sterile tube before shipment.                 Version of Test: 18

Sample type: 1 tube 10 mL Frozen Plasma EDTA or  1 tube 10 mL Frozen Plasma EDTA +  1 tube of Frozen Processed Platelets (see instructions below) To perform the test it is essential the minimum time elapses from extraction to freezing due to possible RNA degradation (Freeze after separating/processing the samples is required). REQUIRED PROCESSING PROTOCOL FOR PLATELY ANALYSIS - Centrifuge 20 min at 120g. - Collect the supernatant and transfer it to a lilac tube with EDTA (gently invert the tube). - Centrifuge 5 min at 120g. - Collect the supernatant and transfer it to a sterile 15ml tube. - Centrifuge 20min at 360g. - Keep the pellet obtained (corresponds to platelets). - Freeze at -80ºC (if it cannot be at -80ºC then at -20ºC).               * For RNA analysis, acknowledging the lability of this molecule and its better preservation in platelets, we offer the possibility to perform the test with isolated platelets and plasma samples in parallel. However, obtaining platelets involves a complex proccesing protocol and may not be possible for all extraction laboratories. Plasma EDTA analysis is perfectly valid and reliable.       Version of Test: 19

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