Tuesday, November 30, 2021

BIOMARKERS IN SOLID TUMORS · IDH1 (R132), IDH2 (R172) · HOT SPOT

Delivery term Modification

Test code: 8333

Effective update from 02/12/2021




PREVIOUS

NEW
        
     
     Delivery time: 7 days
     

        
         
     Delivery time: 9 days
     
     

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APERT SYNDROME - FGFR2 - MUTATIONS S252W, P253R - SEQUENCING

Description and Method Modification

Test code: 7847

Effective update from 02/12/2021




PREVIOUS

NEW
APERT SYNDROME - FGFR2 - MUTATIONS S252W, P253R - SEQUENCING

Method: Sequencing Method        
      
Version of Test: 19
     

APERT SYNDROME · FGFR2(p.S252W, p.P253R) · HOT SPOT        
         
Method: HOT SPOT
             
Version of Test: 20


   Find the record of the test by clicking here

MGMT (promoter) methylation, tissue

Description and Delivery Time Modification

Test code: 3997

Effective update from 02/12/2021




PREVIOUS

NEW
MGMT (promotor) methylation, tissue             
     
     
Delivery term: 20
     
     
Version of Test: 8
     

BIOMARKERS IN SOLID TUMORS · MGMT(PROMOTOR METHYLATION) · METHYLATION        
               
Delivery term: 9 days

     
Version of Test: 9
     

   Find the record of the test by clicking here

Monday, November 29, 2021

GLUTATHION PEROXIDASE, WHOLE BLOOD

Discontinued temporarily

Test code: 3049
Nemonic code: GLPR


Dear colleagues and collaborators,

Due to supply problems with the reagent needed to carry out the GLUTATHION PEROXIDASE, WHOLE BLOOD, we are forced to temporarily suspend its availability from now until a new date.

As soon as information is available about the possible date of normalization of the supply, it will be notified by means of a new communication.

We apologize for the inconvenience caused by this situation.

Description Modification

Effective update from 30/11/2021

CODE

OLD DESCRIPTIVE

NEW DESCRIPTIVE

3344 MLL/AF4 t(4;11) screening, total blood/bone marrow QUANTITATIVE REARRANGEMENT · MLL/AF4 · RT-PCR 
4858 E2A/PBX1 t(1;1) qualitative, bone marrow/ whole blood QUANTITATIVE REARRANGEMENT · TCF3(E2A)/PBX1 · RT-PCR
5163 CBFB/MYH11 inv(16)(p13q22) quantitative, blood/bone marrow QUANTITATIVE REARRANGEMENT · CBFB/MYH11(inv16) · RT-PCR
7027

AML1/ETO t(8;21) screening, total blood/bone marrow

QUANTITATIVE REARRANGEMENT · RUNX1(AML1)/RUNX1T1(ETO) · RT-PCR
4305Chronic Myeloid Leukaemia, CML (T315I-BCR/ABL) screening, total blood CHRONIC MYELOID LEUKEMIA, RESISTANCE TO TYROSINE KINASE INHIBITORS · BCR-ABL1 (T315I) · HOT SPOT
8427LYMPHOCYTES T CLONALITY - LYMPHOCYTE RECEPTOR T TCR REARRANGEMENT  · TCRG · FRAGMENT A. LYMPHOCYTES T CLONALITY - LYMPHOCYTE RECEPTOR T TCR REARRANGEMENT  · TCRG · FRAGMENT A.

7989

HEMATOLOGICAL NEOPLASIAS · CXCR4 · SANGERWALDENSTRÖM MACROGLOBULINEMIA · CXCR4(S338X) · SANGER

Friday, November 26, 2021

Cystic Fibrosis, panel (50 mutations, polyT-CFTR) screening, whole blood

Description and Mutations analyzed Modification

Test code: 4402

Effective update from 30/11/2021




PREVIOUS

NEW

Cystic Fibrosis, panel (50 mutations, polyT-CFTR) screening, whole blood
        
Mutations analyzed:

CFTRdele2,3, R334W, R553X, Y1092X(C>A), E60X, R347P, R560T, M1101K, P67L, R347H, 1811+1.6kbA>G, D1152H, G85E, A455E, 1898+1G>A, R1158X, 394delTT, 2143delT, R1162X, 444delA, 2184delA, 3659delC, R117C, 1677delTA, 2347delG, 3849+10kbC>T, R117H, V520F, W846X, S1251N, Y122X, 1717-1G>A, 2789+5G>A, 3905insT, 621+1G>T, G542X, Q890X, W1282X, 711+1G>T, S549R(T>G), 3120+1G>A, N1303K, L206W, S549N, 3272-26A>G, 1078delT, G551D, R1066C, delI507delF508, A1006E, 1812-1G>A, A561E, 1069delCA, 2869insG, K710X, R709X, 2184insA, 712-1G>T, H199Y, P205S, V232D and the polimorfism IVS8-5T.
     
Version of Test: 37
     


        
Mutation Detection CFTR gen (Cystic Fibrosis)        
                  

         
Mutations analyzed:         
         
CFTRdele2,3, R334W, R553X, Y1092X(C>A), E60X, R347P, R560T, M1101K, P67L, R347H, 1811+1.6kbA>G, D1152H, G85E, A455E, 1898+1G>A, R1158X, 394delTT,
2143delT, R1162X, 444delA, 2184delA, 3659delC, R117C, 1677delTA, 2347delG, 3849+10kbC>T, R117H, V520F, W846X, S1251N, Y122X, 1717-1G>A, 2789+5G>A,
3905insT, 621+1G>T, G542X, Q890X, W1282X, 711+1G>T, S549R(T>G), 3120+1G>A, N1303K, L206W, S549N, 3272-26A>G, 1078delT, G551D, R1066C, I507del, F508del, A1006E, 1812-1G>A, A561E, 2869insG, K710X, R709X, 2184insA, 712-1G>T, H199Y, P205S, V232D and the polymorphism IVS8-5T.     


Version of Test: 38
     


   Find the record of the test by clicking here

PML/RAR t(15;17) screening, total blood/bone marrow

Erased test

Test code: 2742

Alternative: 1156 - QUANTITATIVE REARRANGEMENT · PML/RAR · RT-PCR

Effective update from 30/11/2021

IgE specific antibodies for Japanese cypress (t24)

Reference values Modification

Test code: 4738

Effective update from 29/11/2021




PREVIOUS

NEW
        
NEGATIVE 
- Class 0 : Less than 0.35 kU/L

POSITIVE 
- Class 1 : 0.35 - 0.70 kU/L
- Class 2 : 0.71 - 3.5 kU/L
- Class 3 : 3.6 - 17.0 kU/L
- Class 4 : 17.1 - 50.0 kU/L
- Class 5 : 50.1 - 100.0 kU/L
- Class 6 : More than 100.0 kU/L


 Version of Test: 5
     

        
NEGATIVE 
- Classe 0 : Less than 0.35 kU/L

POSITIVE
- Class 1 : 0.35 - 0.70 kU/L
- Class 2 : 0.71 - 3.59 kU/L
- Class 3 : 3.60 - 17.09 kU/L
- Class 4 : 17.10 - 50.09 kU/L
- Class 5 : 50.10 - 100.0 kU/L
- Classe 6 : Sup. a 100.00 kU/L          

         
Version of Test: 6
     

IgE SPECIFIC ANTIBODIES FOR CHYMOPAPAIN (c-209)

Reference values Modification

Test code: 975

Effective update from 29/11/2021




PREVIOUS

NEW
        
NEGATIVE 
- Class 0 : Less than 0.35 kU/L

POSITIVE 
- Class 1 : 0.35 - 0.70 kU/L
- Class 2 : 0.71 - 3.5 kU/L
- Class 3 : 3.6 - 17.0 kU/L
- Class 4 : 17.1 - 50.0 kU/L
- Class 5 : 50.1 - 100.0 kU/L
- Class 6 : More than 100.0 kU/L


 Version of Test: 5
     

        
NEGATIVE 
- Classe 0 : Less than 0.35 kU/L

POSITIVE
- Class 1 : 0.35 - 0.70 kU/L
- Class 2 : 0.71 - 3.59 kU/L
- Class 3 : 3.60 - 17.09 kU/L
- Class 4 : 17.10 - 50.09 kU/L
- Class 5 : 50.10 - 100.0 kU/L
- Classe 6 : Sup. a 100.00 kU/L          

         
Version of Test: 6
     


   Find the record of the test by clicking here

Method Modification



Effective update from 29/11/2021

All the tests described below will change their Methodology from the date indicated:

Chemiluminescence -> Chemiluminescent Microparticle Immunoassay (CMIA)


CODE

DESCRIPTION

2140

HOMOCYSTEINE, PLASMA

407

PSA (PROSTATE SPECIFIC ANTIGEN), SERUM

238

T3 TOTAL TRIIODOTHYRONINE, SERUM

239

T4 TOTAL THYROXINE, SERUM

249

THYROID STIMULATING HORMONE (TSH), SERUM

3105

BNP (BRAIN NATRIURETIC POLYPEPTIDE)  C-TERMINAL, PLASMA

786

HEPATITIS B SURFACE ANTIBODY (HBs-Ab), SERUM

361

VITAMIN D (25 HYDROXY-CHOLECALCIFEROL), SERUM

 Reference Values, Units and Method Modification



Effective update from 29/11/2021

All the tests described below will change their Methodology from the date indicated:

Chemiluminescence -> Chemiluminescent Microparticle Immunoassay (CMIA)

CODE

DESCRIPTION

PREVIOUS UNITS

NEW UNITS

PREVIOUS REFERENCE VALUE

NEW REFERENCE VALUE

711

T3 FREE, SERUM

 ng/L

 pg/Ml

2.1-4.4 ng/L

1.58-3.91 pg/mL

199

Luteinizing Hormone (LH), serum

UI/L

mIU/mL

Follicular phase: 1.7-15 IU/L
Ovulatory peak: 21.9-56.6 IU/L
Luteinic phase: 0.6-16.3 IU/L
Postmenopause: 14.2-52.3 IU/L
Men: 1.2-7.8 IU/L

Men: 0.57-12.07 mIU/mL
Women with normal menstruation:
     Follicular phase: 1.80-11.78 mIU/mL
     Mid-menstrual cycle peak: 7.59-89.08 mIU/mL
     Luteal phase 0.56-14.00 mIU/mL
Postmenopausal women:
     Without HRT 5.16-61.99 mIU/mL

 Nemonic Code and Reference Values Modification



Effective update from 29/11/2021

CODE

PREVIOUS MNEMOMIC CODE

NEW MNEMOMIC CODE

DESCRIPTION

PREVIOUS REFERENCE VALUE

NEW REFERENCE VALUE

230

RUBG

RUBGD

RUBELLA IgG ANTIBODIES, SERUM

Non-immune: Less than 5.0 IU/mL Undetermined: 5.0 - 9.99 IU/mL Weak immunity: 10 - 15 IU/mL Immune: Greater than 15 IU/mL

Negative: Less than 7 AU/mL Grey zone: 7 - 9.99 AU/mL Positive: Equal to or greater than 10 AU/mL

231

RUBM

RUBMD

RUBELLA IgM ANTIBODIES, SERUM

NEGATIVE: Index less than 0.80 Undetermined: Index between 0.80 - 1.00 POSITIVE: Index greater than 1.00

Negative: Less than 20 AU/mL Grey zone: 20-24.99 AU/mL Positive: Equal to or greater than 25 AU/mL

247

TOXM

TOXMD

TOXOPLASMA GONDII IgM ANTIBODIES, SERUM

Negative: Index less than 0.90 Undetermined: Index between 0.90 - 0.99 Positive: Index greater than or equal to 1.0

Negative: Less than 6 AU/mL Grey zone: 6 - 7.99 AU/mL Positive: Equal to or greater than 8.8 AU/mL

246

TOXO

TOXOD

TOXOPLASMA GONDII IgG ANTIBODIES, SERUM

Negative: Less than 6.4 UI/mL Undetermined: Between 6.4 - 9.9 UI/mL Positive: Greater than or equal to 10.0 UI/mL


Negative: Less than 7.2 AU/mL Grey zone: 7.2-8.79 AU/mL Positive: Greater than or equal to  8.8 AU/mL