PARATHYROID HORMONE RELATED PEPTIDE (PTH-RP), PLASMA

Sample and Delivery Time Modification

Test code: 2431

Effective update from 04/04/2018

PREVIOUS	NEW
Delivery term: 15 days	Sample preservation: Freeze to -70ºC                Delivery term: 11 days

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ONCO IN BLOOD TEST

Description Modification/ Erased tests

Test code: 
         Description modification: 5073, 5074, 7354, 7356, 5075, 7365, 7361
         Erased test: 5570, 5568, 7357, 5569, 7358, 7359

Effective update from 03/04/2018

We proceed to unify the ONCO IN BLOOD determinations (Analysis of somatic mutations of the tumor in peripheral blood) for diagnosis and monitoring of patients in a single test.

Description Modification:

PREVIOUS

NEW

5073- BRAF (Mutations V600E, V600K)  Diagnosis, ONCOinBLOOD (Cell-free DNA detection), plasma and serum 5074- EGFR (exons 19 and 21 + T790M mutation). Diagnosis, ONCOinBLOOD (Cell-free DNA detection), serum and plasma 7354- EGFR (C797S mutation) Diagnosis, ONCOinBLOOD (Cell-free DNA detection), serum and plasma  7356- EML4-ALK Translocation Diagnosis,  ONCOinBLOOD (Cell-free DNA detection), serum and plasma            5075- KRASinBLOOD (ex. 2) screening, serum/plasma 7365- MET (Splicing 7/8, 14) Diagnostic,  ONCOinBLOOD (Cell-free DNA detection), serum and plasma      7361- PIK3CA (Exons 10, 21) Diagnosis, ONCOinBLOOD (Cell-free DNA detection), serum and plasma

5073- ONCO IN BLOOD BRAF (V600E and V600F)    5074- ONCO IN BLOOD EGFR (exons 19, 21 and T790M)     7354- ONCO IN BLOOD EGFR C797S  7356- ONCO IN BLOOD EML4-ALK  5075- ONCO IN BLOOD KRAS (codons 12, 13 and 61)  7365- ONCO IN BLOOD MET (splicing variants 7/8 and 14) 7361- ONCO IN BLOOD PIK3CA (exons 10 and 21)

Erased tests: 

ERASED

ALTERNATIVE

5570- BRAF (V600E, V600K Mutations)  Monitoring, ONCOinBLOOD (Cell-free DNA detection), plasma and serum  5568- EGFR (exons 19 and 21 + T790M mutation) Monitoring, ONCOinBLOOD (Cell-free DNA detection), serum and plasma   7357- EML4-ALK Translocation Monitoring,  ONCOinBLOOD (Cell-free DNA detection), serum and plasma 5569- KRAS (codons 12, 13 and 61) Monitoring ,ONCOinBLOOD (Cell-free DNA detection), plasma and serum  7358- KRAS (exon 2) (Diagnostic),  Cell-free DNA detection, plasma and serum 7359- PIK3CA (Exons 10, 21) Monitoring, ONCOinBLOOD (Cell-free DNA detection), serum and plasma

5073- ONCO IN BLOOD BRAF (V600E and V600F)    5074- ONCO IN BLOOD EGFR (exons 19, 21 and T790M)     7356- ONCO IN BLOOD EML4-ALK  5075- ONCO IN BLOOD KRAS (codons 12, 13 and 61)  5075- ONCO IN BLOOD KRAS (codons 12, 13 and 61) 7361- ONCO IN BLOOD PIK3CA (exons 10 and 21)

MEASLES IgG ANTIBODIES, SERUM

Reference values and Delivery Time Modification

Test code: 233

Actualización vigente el 28/03/2018

ANTERIOR	ACTUAL
Method          : Enzyme immounoassay      Delivery term   : 5 days	Method          : Chemiluminiscence  Delivery term   : 2 days

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MEASLES IgM ANTIBODIES, SERUM

Method and Delivery Time Modification

Test code: 234

Actualización vigente el 28/03/2018

ANTERIOR	ACTUAL
Method          : Enzyme immounoassay      Delivery term   : 5 days	Method          : Chemiluminiscence  Delivery term   : 2 days

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BILIRUBIN

Reference values and Description

Test code: 875

Effective update from 03/04/18

PREVIOUS	NEW
BILIRUBIN                Total : Less than 1 mg/dL              Direct  : Less than 0.3 mg/dL       Indirect: Less than 0.9 mg/dL	INDIRECT BILIRUBIN, SERUM        Total:       From 0 to 1 day  : 2 - 6 mg /dL      From 1 to 2 days : 6 - 10 mg/dL      From 2 to 5 days : 4 - 8 mg/dL      From 5 days to 17 years : Less than 1 mg/dL      > 17 years : Less than 1.2 mg/dL        Direct   : Less than 0.3 mg/dL    Indirect : Less than 0.9 mg/dL

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FREE PHENYTOIN, SERUM

Method, Units and Reference values Modification

Test code: 1930

Effective update from 27/03/2018

PREVIOUS	NEW
Method           : Enzime immunoassay Units            : µg/mL      Therapeutic level: 1 - 2 µg/mL	Method           : HPLC  Units            : mg/L   Therapeutic level: 0.5 - 2 mg/L

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Herpes human virus type 8 (HHV-8) DNA, biological sample

Reference values and Delivery Time Modification

Test code: 3607

Effective update from 29/03/2018

PREVIOUS	NEW
NEGATIVE                   Delivery term: 7 days	Not detected.                          Delivery term: 6 days

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Haemophilia B (F) sequencing, total blood

Delivery Time Modification

Test code: 3610

Effective update from 29/03/18

PREVIOUS	NEW
Delivery term: 22 days	Delivery term: 30 days

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IMMUNOFIXATION, CSF

Erased test

Test code: 7717

Effective update from 29/03/18

Alternative test:

4370- ISOELECTROFOCUSING, CSF*

*It is essential to send sample of SERUM and sample of CFS together for this test:

          Minimum amount:    CFS:   500 µL

                             SERUM: 300 µL

          Optimal amount:    CFS:  1000 µL

                             SERUM: 500 µL

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BREATH TEST - BACTERIAL OVERGROWTH (LACTITOL)

New Test in NOÛS Catalog

Test Code: 7737

Sample:	Special tube provided by NOÛS
Conservation:	Room temperature
Method:	Gas Chromatography/Mass Spectrometry
Set Up Days:	Daily
Delivery term:	13 days
Information:
Approximately half of our daily need of calories derived from carbohydrates. Most of these are ingested in the form of starch, which by salivary and pancreatic amylase is hydrolyzed and gives rise to oligosaccharides and then disaccharides (sucrose, maltose and lactose) and monosaccharides (glucose fructose and galactose). The latter are absorbed directly into the small intestinal epithelium without previous digestion. However, the disaccharides must be cleaved by enzymes previously found in the villous epithelial cells. An insufficient digestion or absorption of carbohydrates exposed them to a bacterial fermentation in the distal small intestine and colon. During fermentation originate short chain fatty acids and gases such as carbon dioxide (C02) and hydrogen (H2). These gases diffuse partially into the blood and are then exhaled. Because the body H2 is formed exclusively by bacterial fermentation of carbohydrates, the concentration of H2 in the exhaled air reflects the decomposition thereof in the intestine. Therefore, the determination of H2 can be used in the exhaled air to show an abnormal breakdown and poor absorption of carbohydrates. Fasting produces little or no H2 excretion through the lungs. However, the appearance of H2 with fasting can be relatively high if the intestine due to an insufficient fasting, it contains many carbohydrate residues. If a carbohydrate, after being administered is not completely absorbed increases the excretion of H2. However, if the absorption is insufficient, one part arrives at the colon and fermentation occurs with the consequent production of H2. In the case of bacterial overgrowth in the small intestine, the fermentation of carbohydrates can increase the excretion of H2 at 30-45 min after administration. This increase reflects the fermentation of the unabsorbed part of the carbohydrate. Thus, when using differents types of carbohydrates can be demonstrated alterations in the digestion and absorption of monosaccharides, disaccharides or polysaccharides. In an insufficient absorption of any carbohydrate is followed by production of H2, and consequently a positive breath hydrogen tests. In some individuals the bacteria colonizing the colon are not producing H2 and instead produce methane (CH4), so it is recommended that the joint determination of these two gases.

Modification sample collection times

Test code: 7737

Effective update from 26/03/18

PREVIOUS	NEW
Sample collection time:         - BASAL     - 30 min      - 60 min      - 90 min      - 120 min	Sample collection time:          - BASAL     - 30 min      - 60 min      - 90 min      - 120 min     - 150 min     - 180 min     - 210 min

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Hepatitis D virus (HDV) RNA viral load, serum

Delivery Time Modification

Test code: 1988

Effective update from 23/03/2018

PREVIOUS	NEW
Delivery term: 15 days	Delivery term: 20 days

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Hepatitis B virus (HBV) DNA genotype, serum

Reference values and Delivery Time Modification

Test code: 3211

Effective update from 23/03/2018

PREVIOUS	NEW
Technique: Extraction of HBV-DNA and PCR amplification. Genotyping by hybridization. This technique allows the identification of genotypes A, B, C, D, E, F and G.                   Delivery term: 7 days	Technique: Extraction of HBV-DNA and PCR amplification. Genotyping by hybridization. This technique allows the identification of genotypes A, B, C, D, E, F, G and H.                   Delivery term: 6 days

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