Thursday, March 23, 2023

BROMIDE, URINE

Method Modification

Test code: 3562

Effective update from 03/04/2023



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      Ion Selective Electrode
     
     
      Version of Test: 2
     

        
  Inductively Coupled Plasma/ Mass Spectrometry (ICP-MS)       
         
      Version of Test: 3
     

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Beta 2 Defensin, Stool

Delivery Time Modification

Test code: 7632
Nemonic code:  B2DEFH 

Effective update from 27/03/2023




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NEW
      
      Delivery term: 9 days
     
        
      Delivery term: 13 days
     
     

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Friday, March 17, 2023

Plasmodium DNA, total blood

Delivery Time Modification, Additional information (*)

Test code: 2964
Nemonic code: DBPS

Effective update from 03/27/2023




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NEW
        
          
     
      Delivery term: 8 days      

        
         
         
     Delivery term: 4 days

     

 (*)  Note: For positive results, the coded species will be reported.


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Thursday, March 16, 2023

Karyotype, total blood, amniotic fluid, haematological, tissue, total cord blood, fibroblasts, culture, chorionic villus (culture)

Reference values Modification

Test code: 684, 907, 1106, 2260, 2533, 5446, 3474
Nemonic code: Does not apply

Effective update from 03/27/2023

Test Code: 684

 

Karyotype, total blood

 

Previous References Values

New References Values

Technique: Cell culture for 48-72 hours stimulated with PHA (phytohemagglutinin). G-Banded Chromosomal Analysis (2020). Resolution level: 400-550 bands. Minimum number of metaphases studied: 15.
Limitations: This result does not include chromosomal findings interpreted as normal variants (European Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of analysis. studies, such as, among others, the presence of certain mosaic situations, small chromosomal abnormalities and discrepancies between tissues.

4. Methodology
             Cell culture (48h and 72h) stimulated with PHA (phytohemaglutinin). Identification by G bands (ISCN 2020). Resolution: 400-550 bands. Minimum number of metaphases analyzed: 15.

5. Limitations and recommendations
             - The present result does not include the chromosomal findings interpreted as variants of normality (European Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of studies, such as, among others, the presence of certain situations in mosaic, chromosomal cryptic or small size anomalies and discrepancies between tissues.
             - This report must be accompanied by the corresponding karyotype image and must be interpreted within the  clinical context of the patient and according to medical criteria.

Test Code: 907

 

Karyotype, amniotic fluid

 

Previous References Values

New References Values

Technique: Cell culture. Analysis of two independent cultures. G-Banded Chromosomal Analysis (2020). Resolution level: 400-550 bands. Minimum number of metaphases studied: 20.
Limitations: This result does not include the findings interpreted as variants of normality (European Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of study. such as, among others, the presence of certain mosaic situations, small chromosomal abnormalities, discrepancies between tissues and contamination with maternal cells.
This report must be accompanied by the image of the corresponding karyotype and must be interpreted within the clinical context of the patient and according to medical criteria.

4. Methodology
             Cell culture. Identification by G bands (ISCN 2020) from two independent cultures. Resolution: 400-550 bands. Minimum number of metaphases analyzed: 20.

5. Limitations and recommendations
             - The present result does not include the chromosomal findings interpreted as variants of normality (European Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of studies, such as, among others, the presence of certain situations in mosaic, chromosomal cryptic or small size anomalies, discrepancies between tissues and maternal contamination.
             - This report must be accompanied by the corresponding karyotype image and must be interpreted within the clinical context of the patient and according to medical criteria.

Test Code: 1016

 

Karyotype haematological

 

Previous References Values

New References Values

Technique: Cell culture (24 hours without stimulation and/or 72 hours stimulated with TPA (tetradecanoylphorbol acetate) or PHA (phytohemagglutinin), depending on diagnostic orientation). G-Banded Chromosomal Analysis (2020). Resolution level: 400-550 bands. Minimum number of metaphases studied: 20.
Limitations: This result does not include the findings interpreted as variants of normality (European Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of study. , mainly the absence of growth of pathological cells, the possible non-detection of some mosaics and small structural alterations.
This report must be accompanied by the image of the corresponding karyotype and must be interpreted within the clinical context of the patient and according to medical criteria.

             4. Methodology                                                                                             Cell culture, with or without stimulation with TPA (tetradecanoylphorbol acetate) or PHA (phytohemagglutinin), depending on diagnostic orientation*. Identification by G bands (ISCN 2020) in two independent cultures. Resolution: 300-400 bands. Minimum number of metaphases analyzed: 20

             *1) Myeloproliferative neoplasia, Myelodysplastic syndrome, Acute leukemia, not indicated: direct cultures and 24 hours without mitogen. 2) Multiple myeloma: direct cultures and 72 hours without mitogen. 3)Chronic Lymphoproliferative Syndrome of B cells, Chronic Lymphoid Leukemia: direct cultures and 72 hours stimulated with TPA. 4) Chronic Lymphoproliferative Syndrome of T cells: direct cultures and 72 hours stipulated with PHA.

5. Limitations and recommendations
             - This result is issued following the criteria of the European Cytogeneticists Association (ECA),http//www.e-c-a.eu/EN/GUIDELINES.html).
             - This study does not include chromosomal findings interpreted as normal variants and is subject to the limitations of this type of study, mainly the absence of growth of pathological cells, the possible non-detection of some mosaics and small structural alterations.
             - The guidelines indicate that the conventional karyotype is not the most recommended analysis in cases of MM, although it can be performed to complete the study if there is a sufficient sample (Multiple Myeloma Guideline of the Spanish Group, 2021).
             - This report must be accompanied by the corresponding karyotype image(s) and must be interpreted within the clinical context of the patient and according to medical criteria.

Test Code: 2260

 

Karyotype, tissue

 

Previous References Values

New References Values

Technique: Cell culture. G-Banded Chromosomal Analysis (2020). Resolution level: 400-550 bands. Minimum number of metaphases studied: 15.
Limitations: This result does not include the findings interpreted as variants of normality (European Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of study. such as, among others, the presence of certain mosaic situations, small chromosomal abnormalities, discrepancies between tissues and contamination with maternal cells.
This report must be accompanied by the image of the corresponding karyotype and must be interpreted within the clinical context of the patient and according to medical criteria.

4. Methodology
             Cell culture. Identification by G bands (ISCN 2020). Resolution: 400-550 bands. Minimum number of metaphases analyzed: 15.

5. Limitations and recommendations
             - The present result does not include the chromosomal findings interpreted as variants of normality (European
             Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of studies, such as, among others, the presence of certain situations in mosaic, chromosomal cryptic or small size anomalies, discrepancies between tissues and maternal contamination.
             - This report must be accompanied by the corresponding karyotype image(s) and must be interpreted within the clinical context of the patient and according to medical criteria.

Test Code: 2533

 

Karyotype, total cord blood

 

Previous References Values

New References Values

Technique: Cell culture for 48-72 hours stimulated with PHA (phytohemagglutinin). G-Banded Chromosomal Analysis (2020). Resolution level: 400-550 bands. Minimum number of metaphases studied: 15.
Limitations: This result does not include chromosomal findings interpreted as normal variants (European Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of analysis. studies, such as, among others, the presence of certain mosaic situations, small chromosomal abnormalities and discrepancies between tissues.
This report must be accompanied by the image of the corresponding karyotype and must be interpreted within the clinical context of the patient and according to medical criteria.

4. Methodology
             Cell culture (48h and 72h) stimulated with PHA (phytohemaglutinin). Identification by G bands (ISCN 2020). Resolution: 400-550 bands. Minimum number of metaphases analyzed: 15.

             5. Limitations and recommendations
             - The present result does not include the chromosomal findings interpreted as variants of normality (European Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of studies, such as, among others, the presence of certain situations in mosaic, chromosomal cryptic or small size anomalies, discrepancies between tissues and maternal contamination.
             - This report must be accompanied by the corresponding karyotype image and must be interpreted within the clinical context of the patient and according to medical criteria.

Test Code: 5446

 

Karyotype, fibroblasts

 

Previous References Values

New References Values

Technique: Cell culture. G-Banded Chromosomal Analysis (2020). Resolution level: 400-550 bands. Minimum number of metaphases studied: 15.
Limitations: This result does not include the findings interpreted as variants of normality (European Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of study. such as, among others, the presence of certain mosaic situations, small chromosomal abnormalities, discrepancies between tissues and contamination with maternal cells.
This report must be accompanied by the image of the corresponding karyotype and must be interpreted within the clinical context of the patient and according to medical criteria.

4. Methodology
             Cell culture. Identification by G bands (ISCN 2020) from two independent cultures. Resolution: 400-550 bands. Minimum number of metaphases analyzed: 20.

5. Limitations and recommendations
             - The present result does not include the chromosomal findings interpreted as variants of normality (European Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of studies, such as, among others, the presence of certain situations in mosaic, chromosomal cryptic or small size anomalies, discrepancies between tissues and maternal contamination.
             - This report must be accompanied by the corresponding karyotype image and must be interpreted within the clinical context of the patient and according to medical criteria.

Test Code: 9605

 

Karyotype, culture

 

Previous References Values

New References Values

Technique: Cell culture for 48-72 hours stimulated with PHA (phytohemagglutinin). G-Banded Chromosomal Analysis (2020). Resolution level: 400-550 bands. Minimum number of metaphases studied: 15.
Limitations: This result does not include chromosomal findings interpreted as normal variants (European Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of analysis. studies, such as, among others, the presence of certain mosaic situations, small chromosomal abnormalities and discrepancies between tissues.

4. Methodology
             Cell culture (48h and 72h) stimulated with PHA (phytohemaglutinin). Identification by G bands (ISCN 2020). Resolution: 400-550 bands. Minimum number of metaphases analyzed: 15.

5. Limitations and recommendations
             - The present result does not include the chromosomal findings interpreted as variants of normality (European Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of studies, such as, among others, the presence of certain situations in mosaic, chromosomal cryptic or small size anomalies and discrepancies between tissues.
             - This report must be accompanied by the corresponding karyotype image and must be interpreted within the  clinical context of the patient and according to medical criteria.

Test Code: 3474

 

Karyotype, chorionic villus (culture)

 

Previous References Values

New References Values

Technique: Cell culture. Analysis of two independent cultures. G-Banded Chromosomal Analysis (2020). Resolution level: 400-550 bands. Minimum number of metaphases studied: 20.
Limitations: This result does not include the findings interpreted as variants of normality (European Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of study. such as, among others, the presence of certain mosaic situations, small chromosomal abnormalities, discrepancies between tissues and contamination with maternal cells.
This report must be accompanied by the image of the corresponding karyotype and must be interpreted within the clinical context of the patient and according to medical criteria.

4. Methodology
             Cell culture. Identification by G bands (ISCN 2020) from two independent cultures. Resolution: 400-550 bands. Minimum number of metaphases analyzed: 20.

 5. Limitations and recommendations
             - The present result does not include the chromosomal findings interpreted as variants of normality (European Cytogeneticists Association (ECA) http://www.eca.eu/EN/GUIDELINES.html) and is subject to the limitations of this type of studies, such as, among others, the presence of certain situations in mosaic, chromosomal cryptic or small size anomalies, discrepancies between tissues and maternal contamination.
             - This report must be accompanied by the corresponding karyotype image and must be interpreted within the clinical context of the patient and according to medical criteria.

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Wednesday, March 15, 2023

Fragile-X Syndrome type E, FRAXE (FMR2) screening, dried blood

Description Modification

Test code: 1427
Nemonic code: Does not apply

Effective update from 03/27/2023




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    Fragile-X Syndrome type E, FRAXE (FMR2) screening, dried blood
    
   
    Version of Test: 8
     
    
    INTELLECTUAL DISABILITY ASSOCIATED WITH FRAGILE SITE FRAXE · FMR2 · FRAGMENT A.

    
    Version of Test: 9

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Tuesday, March 14, 2023

COCAINE, URINE

Description, Method and Reference values Modification

Test code: 317

Effective update from 03/27/2023




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COCAINE, URINE

Method: Enzyme multiplied Immunoassay


Reference Values:
Negative: Less than 150 ng/mL
     

Version of Test: 3
     

QUALITATIVE SCREENING OF COCAINE, URINE       

Method: Enzyme Immnunoassay         


Reference Values:   
The discriminant value of the technique is 150 ng/mL
     
Version of Test: 4
     


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AMPHETAMINES AND METANPHETAMINES, BARBITURATES, BENZODIAZEPINES, OPIATES, TETRAHYDROCANNABINOL (CANNABIS), URINE

Description and Reference values Modification

Test code: 285, 294, 295. 210, 306
Nemonic code: Does not apply

Effective update from 03/27/2023


Code: 285

 

Previous Description

New Description

Amphetamines and metanphetamines, urine

QUALITATIVE SCREENING OF AMPHETAMINES AND METAPHETAMINES, URINE

Previous Reference Values

New Reference Values

Report with Qualitative result:
NEGATIVE.
Note: The discriminant value of the technique is 500 ng / mL

The discriminant value of the technique is 500 ng / mL

This assay allows the detection of d-amphetamine, d-metanphetamine, MDA, MDEA and MDMA .

Code: 294

 

Previous Description

New Description

BARBITURATES, URINE

QUALITATIVE SCREENING OF BARBITURATES, URINE

Previous Reference Values

New Reference Values

Negative: Less than 200 ng/mL
Sensibility: < 25 ng/mL

The discriminant value of the technique is 200 ng/mL

Code: 295

 

Previous Description

New Description

BENZODIAZEPINES, URINE

QUALITATIVE SCREENING OF BENZODIAZEPINES, URINE

Previous Reference Values

New Reference Values

Negative: Less than 200 ng/mL
Sensibility: <5.8 ng/mL

The discriminant value of the technique is 200 ng/mL

Code: 210

 

Previous Description

New Description

OPIATES , URINE

QUALITATIVE SCREENING OF OPIATES , URINE

Previous Reference Values

New Reference Values

Negative: Less than 2000 ng/mL

The discriminant value of the technique is 2000 ng/mL

Code: 306

 

Previous Description

New Description

TETRAHYDROCANNABINOL (CANNABIS), URINE

QUALITATIVE SCREENING OF TETRAHYDROCANNABINOL (CANNABIS), URINE

Previous Reference Values

New Reference Values

Negative: Less than 50 ng/mL
Sensibility: < 10 ng/mL

The discriminant value of the technique is 50 ng/mL

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