Friday, December 30, 2022

PROTEIN ELECTROPHORESIS, CSF

Reference values Modification

Test code: 226
Nemonic code: PRGL

Effective update from 09/01/2023




PREVIOUS

NEW
        
      Prealbumin : 3 - 7 %
      Albumin : 50 - 70 %
      Alpha-1-Globulin : 3 - 7 %
      Alpha-2-Globulin : 4 - 8 %
      Beta-Globulin : 8 - 12 %
      Tau-Globulin : 3 - 8 %
      Gamma-Globulin : 3 - 10 %
      Globulin total : 20 - 45 %
      Albumin/globulin ratio: 0 - 5
      Protein total : 15 - 45 mg/dL
     
      NOTE: Film and graphic are attached.
      * Fuente: PNT, Insert
     












      Version of Test: 20
     

        
      Prealbumin : 2.0 - 7.0 %
      Albumin : 56.0 - 76.0 %
      Alpha-1-Globulin : 2.0 - 7.0 %
      Alpha-2-Globulin : 4.0 - 12.0 %
      Beta-Globulin : 5.3 - 12.0 %
      Tau-Globulin : 2.7 - 6.0 %
      Gamma-Globulin : 3.0 - 12.0 %
      Globulin total : 17.0 - 49.0 %
      Albumin/globulin ratio: 0 - 4.5
      Protein total : 15.0 - 45.0 mg/dL
     
      NOTE: Film and graphic are attached.    
         
       * Recommendations for the study of cerebrospinal fluid proteins, Spanish Society of Clinical Biochemistry and Molecular Pathology, 2014.
         
         
         
         
         
         
         
         
         
               
      Version of Test: 21
     


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ARABINOSE TEST, URINE

Erased test (Definitive)

Test code: 3772 - ARABINOSE TEST, URINE
Nemonic test: AROR

Effective update from 02/01/2023



APC RESISTANCE (ACTIVATED PROTEIN C RESISTANCE), PLASMA

Comment Reference values Modification

Test code: 3084
Nemonic code: RPCAGL

Effective update from 09/01/2023


The reference values does not chance, the changes are indicated in Bold.


PREVIOUS

NEW
        
      > 1.5
      
     










      Version of Test: 26
     

        
      > 1.5
         
      
      The ratio between 1.5 and 2.1 may indicate low levels of protein C and should be investigated further. These investigations may include specific tests for protein C and test for DNA.
      
      Samples with positive or borderline value results must be verified by genetic analysis.    
     


      Version of Test: 27
     


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YERSINIA ENTEROCOLITICA ANTIBODIES IgM, SERUM

Reference values Modification

Test code: 9759 - YERSINIA ENTEROCOLITICA  ANTIBODIES IgM, SERUM
Nemonic code: YERENM

Alternative:

Test code: 9786 - YERSINIA ENTEROCOLITICA  ANTIBODIES IgM, SERUM*
Nemonic code: YEENM

The test 9786 measures the IgM antibodies 0:3, 0:4, 0:6,0:9 of Yersinia enterocolitica

Effective update from 02/01/2023


BETHA-GLUCOCEREBROSIDASE (GAUCHER DISEASE), BLOOD SPOT

New Test in NOÛS Catalog

Test Code: 9787

Sample:
Dried blood on filter paper
Conservation:
Room temperature
Method:
Fluorimetry
Set Up Days:
Daily
Delivery term:
17 days

    Find the record of the test by clicking here

Thursday, December 29, 2022

YERSINIA ENTEROCOLITICA ANTIBODIES IgM, SERUM

New Test in NOÛS Catalog

Test Code: 9786

Sample:
Serum (1 ml)
Conservation:
Refrigerated
Method:
Indirect fluorescent antibody
Set Up Days:
Daily
Delivery term:
9 days

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CISTICERCOSIS (TAENIA SOLIUM) IgG ANTIBODIES, SERUM

Delivery Time Modification

Test code: 2237
Nemonic code: TENIA

Effective update from 02/01/2023




PREVIOUS

NEW
      
      Delivery term: 20 days
     


      Delivery term: 10 days
     

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Friday, December 23, 2022

SEROTONIN , URINE

Sample, Method, Reference values and Delivery Time Modification

Test code: 817
Nemonic code: SEOR

Effective update from 02/01/2023




PREVIOUS

NEW
      Sample: Preserve the urine by adding 10-15 mL 6 M HCl (hydrochloric acid). Protect from light. 

      Method: Radioimmunoassay

      Reference Values:
      50 - 250 µg/24h
      
     

      Delivery term: 4 days
     
     
      Version of Test: 18
     

      Sample: Preserve the urine by adding 10-15 mL of Clorhidric Acid. Protect from light. 
       
      Method: Enzymeimmunoassay

      Reference Values:
      9 - 193 µg/24h   
         

     
      Delivery term: 10 days
     
     
      Version of Test: 19
     

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Thursday, December 22, 2022

TRANSCOBALAMIN, SERUM

Erased Test

Test code: 1971
Nemonic code: TCBM

Effective update from 27/12/2022



Wednesday, December 21, 2022

Alpha 1-Antitrypsin Deficiency (SERPINA1) genotype, total blood

Descripcion and Reference values Modification

Test code: 2825
Nemonic code: GA1AT

Effective update from 02/01/2023




PREVIOUS

NEW
Description: Alpha 1-Antitrypsin Deficiency (SERPINA1) genotype, total blood


Reference values:
   
Technique: Qualitative detection of Pi*S, Pi*Z and Pi*M (without variants) alleles of the Alpha-1 A gene (AAT) in peripheral whole blood by PCR-ARMS.
     
NOTE:
The congenital deficiency of alpha-1 AT is the most common genetic cause of increased risk of developing lung and liver disease. Most individuals affected by this deficit are carriers of Pi*ZZ or Pi*SZ genotypes.
     
     
Version of Test: 16
     

Description: GENETIC STUDY OF ALPHA-1-ANTITRYPSIN (GENOTYPE Pi)- SERPINA1- SCREENING


Reference values:

See the attached report






          
         
         
         
         
     
Version of Test: 17
     

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CLAUSS TEST (FIBRINOGEN), PLASMA

Description Modification

Test code: 9572
Nemonic code: FIBVC
Effective update from 02/01/2023




PREVIOUS

NEW
        
      CLAUSS TEST (FIBRINOGEN), PLASMA
     
     
      Version of Test: 15
     

        
      DIRECT FIBRINOGEN (VON CLAUSS), PLASMA   
         
     
      Version of Test: 16
     

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FIBRINOGEN, PLASMA

Description Modification

Test code: 168
Nemonic code: FIBR

Effective update from 02/01/2023




PREVIOUS

NEW
        
      FIBRINOGEN, PLASMA 
     
     
      Version of Test: 15
     

        
      DERIVED FIBRINOGEN, PLASMA   
         
     
      Version of Test: 16
     

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Serotonin platelets, plasma EDTA

Discontinued Temporarily (National Only)

Test code: 5135
Nemonic code: SERPLA

Effective update from 27/12/2022

Due to problems with the supply of reagent for the analysis of the 5135- Serotonin platelets, plasma EDTA we are forced to temporarily suspend its availability from December 27th until a new date.

As soon as information about the possible date of resolution is available, it will be notified by means of a new communication.

We regret the inconvenience caused by this situation.

Factor XII (C'6T-F12) screening, total blood

Description and Reference values Modification

Test code: 7002
Nemonic code: GFXII

Effective update from 02/01/2023




PREVIOUS

NEW
      Description:  Factor XII (C'6T-F12) screening, total blood


      Reference values:

 
      Not detected.
     
     
      Version of Test: 5
     

      Description: GENETIC STUDY OF THE 46 C>T OF THE F12 GENE (COAGULATION FACTOR XII)


      Reference values:


      See the attached report.   
           
     
      Version of Test: 6
     


   Find the record of the test by clicking here

Tuesday, December 20, 2022

GASTRINE [RIA], SERUM

Discontinued Temporarily

Test code: 8957
Nemonic code: GASR

Effective update from 20/12/2022

Dear colleagues and collaborators,

We inform you that the temporary discontinuation of the 8957 – GASTRINE [RIA], SERUM is proceeding, from today 20/12/2022, and until further notice.

The reason is the discontinuity of the reagent by the supplier, which is why we are forced to adopt this measure.

As soon as the situation normalizes, we will inform you.
If you have any questions about it, do not hesitate to contact us.

We are sorry for the inconvenience.

Karyotype haematological, whole blood

Erased test (National Only)

Test code: 4479 - Karyotype haematological, whole blood
Nemonic code: CASPH

Alternative: 1016 - Karyotype haematological*
Nemonic code: MEDU

*The accepted samples are: Peripherical Blood - Heparin and Bone Marrow - Heparin.

Effective update from 27/12/2022



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FECES DIGESTION

Erased Test (International Only)

Test code: 803
Nemonic code: Not applicated

Effective update from 27/12/2022

 Erased test for international shipments due to sample stability (3 days Refrigerated).

STREPTOCOCCUS PYOGENES DNA, BIOLOGICAL SAMPLE

New Test in NOÛS Catalog

Test Code: 9780

Sample:
Biological Sample
Conservation:
Refrigerated
Method:
Polymerase chain reaction
Set Up Days:
Daily
Delivery term:
4 days
Information:

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Monday, December 19, 2022

BIOMARKERS IN SOLID TUMOR EXTENDED · PANEL · NGS

Erased test

Test code: 8046 - BIOMARKERS IN SOLID TUMOR EXTENDED · PANEL · NGS
Nemonic code: G15062

Alternative:

Test code: 9779 - BIOMARKERS IN SOLID TUMOR EXTENDED · PANEL · NGS
Nemonic code: G15183

Effective update from 23/12/2022


Studied Genes  8046
Studied genes 9779
NGS panel for the identification of biomarkers with clinical validity in solid tumors. Mutations, change of copies and rearrangements in 161 genes with clinical value:

Point mutations in hotspots: AKT1, AKT2, AKT3, ALK, AR, ARAF, AXL, BRAF, BTK, CBL, CCND1, CDK4, CDK6, CHEK2, CSF1R, CTNNB1, DDR2, EGFR, ERB83, ERBB2, ERBB4, ERCC2, ESR1, EZH2, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, FOXL2, GATA2, GNA11, GNAQ, GNAS, H3F3A, HIST1H3B, HNF1A, HRAS, IDH1, IDH2, JAK1, JAK2, JAK3, KDR, KIT, KNSTRN, KRAS, MAGOH, MAP2K1, MAP2K2, MAP2K4, MAPK1, MAX, MDM4, MED12, MET, MTOR, MYC, MYCN, MYD88, NFE2L2, NRAS, NTRK1, NTRK2, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PPP2R1A, PTPN11, RAC1, RAF1, RET, RHEB, RHOA, ROS1, SF3B1, SMAD4, SMO, SPOP, SRC, STAT3, TERT, TOP1, U2AF1, XPO1.

Study of the complete coding sequence of: ARID1A, ATM, ATR, ATRX, BAP1, BRCA1, BRCA2, CDK12, CDKN1B, CDKN2A, CDKN2B, CHEK1, CREBBP, FANCA, FANCD2, FANCI, FBXW7, MLH1, MRE11A, MSH2, MSH6, NBN, NF1, NF2, NOTCH1, NOTCH2, NOTCH3, PALB2, PIK3R1, PMS2, POLE, PTCH1, PTEN, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RB1, RNF43, SETD2, SLX4, SMARCA4, SMARCB1, STK11, TP53, TSC1, TSC2.
Copy changes (CNVs) in the following genes: AKT1, AKT2, AKT3, ALK, AR, AXL, BRAF, CCND1, CCND2, CCND3, CCNE1, CDK2, CDK4, CDK6, CDKN2A, CDKN2B, EGFR, ERBB2, ESR1, FGF19, FGF3, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, IGF1R, KIT, KRAS, MDM2, MDM4, MET, MYC, MYCL, MYCN, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PPARG, RICTOR, TERT, TSC1, TSC2.


Rearrangements (translocations / fusions) in the following genes: ALK, AXL, BRAF, EGFR, ERBB2, ERG, ETV1, ETV4, ETV5, FGFR1, FGFR2, FGFR3, NTRK1, NTRK3, PDGFRA, PPARG, RAF1, RET, ROS1, AKT2, AR, BRCA1, BRCA2, CDKN2A, ERB84, ESR1, FGR, FLT3, JAK2, KRAS, MDM4, MET, MYB, MYBL1, NF1, NOTCH1, NOTCH4, NRG1, NTRK2, NUTM1, PDGFRB, PIK3CA, PRKACA, PRKACB, PTEN, RAD51B, RB1, RELA, RSPO2, RSPO3, TERT.


NGS panel for the identification of biomarkers with clinical validity in solid tumors. Mutations, change of copies and rearrangements in 500 genes with clinical value:

Point mutations in hotspots: ABL1, ABL2, ACVR1, AKT1, AKT2, AKT3, ALK, AR, ARAF, ATP1A1, AURKA, AURKC, AXL, BCL2, BCL2L12, BCL6, BCR, BMP5, BRAF, BTK, CAC- NA1D, CARD11, CBL, CCND1, CCND2, CCND3, CCNE1, CD79B, CDK4, CDK6, CSF1R, CTNNB1, CUL1, CYSLTR2, CHD4, DDR2, DGCR8, DROS- HA, E2F1, EGFR, EIF1AX, EPAS1, ERBB2, ERBB3, ERBB4, ESR1, EZH2, FAM135B, FGF7, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, FLT4, FOXA1, FOXL2, FOXO1, GATA2, GLI1, GNA11, GNAQ, GNAS, H2BC5, H3-3A, H3-3B, H3C2, HIF1A, HRAS, IDH1, IDH2, IKBKB, IL6ST, IL7R, IRF4, IRS4, KDR, KIT, KLF4, KLF5, KNSTRN, KRAS, MAGOH, MAP2K1, MA- P2K2, MAPK1, MAX, MDM4, MECOM, MED12, MEF2B, MET, MITF, MPL, MTOR, MYC, MYCN, MYD88, MYOD1, NFE2L2, NRAS, NSD2, NT5C2, NTRK1, NTRK2, NTRK3, NUP93, PAX5, PCBP1, PDGFRA, PD- GFRB, PIK3C2B, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R2, PIM1, PLCG1, PPP2R1A, PPP6C, PRKACA, PTPN11, PTPRD, PXDNL, RAC1, RAF1, RARA, RET, RGS7, RHEB, RHOA, RICTOR, RIT1, ROS1, RPL10, SETBP1, SF3B1, SIX1, SIX2, SLCO1B3, SMC1A, SMO, SNCAIP, SOS1, SOX2, SPOP, SRC, SRSF2, STAT3, STAT5B, STAT6, TAF1, TERT, TGF- BR1, TOP1, TPMT, TRRAP, TSHR, U2AF1, USP8, WAS, XPO1, ZNF217, ZNF429.

 

Study of the complete coding sequence of: ABRAXAS1, ACVR1B, ACVR2A, ADAMTS12, ADAMTS2, AMER1, APC, ARHGAP35, ARID1A, ARID1B, ARID2, ARID5B, ASXL1, ASXL2, ATM, ATR, ATRX, AXIN1, AXIN2, B2M, BAP1, BARD1, BCOR, BLM, BMPR2, BRCA1, BRCA2, BRIP1, CALR, CASP8, CBFB, CD274, CD276, CDC73, CDH1, CDH10, CDK12, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CIC, CIITA, CREBBP, CSMD3, CTCF, CTLA4, CUL3, CUL4A, CUL4B, CYLD, CYP2C9, CYP2D6, CHEK1, CHEK2, DAXX, DDX3X, DICER1, DNMT3A, DOCK3, DPYD, DSC1, DSC3, ELF3, ENO1, EP300, EPCAM, EPHA2, ERAP1, ERAP2, ERCC2, ERCC4, ERCC5, ERRFI1, ETV6, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAS, FAT1, FBXW7, FUBP1, GATA3, GNA13, GPS2, HDAC2, HDAC9, HLA-A, HLA-B, HNF1A, ID3, INPP4B, JAK1, JAK2, JAK3, KDM5C, KDM6A, KEAP1, KLHL13, KMT2A, KMT2B, KMT2C, KMT2D, LARP4B, LATS1, LATS2, MAP2K4, MAP2K7, MAP3K1, MAP3K4, MAPK8, MEN1, MGA, MLH1, MLH3, MRE11, MSH2, MSH3, MSH6, MTAP, MTUS2, MUTYH, NBN, NCOR1, NF1, NF2, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PALB2, PARP1, PARP2, PARP3, PARP4, PBRM1, PDCD1, PDCD1LG2, PDIA3, PGD, PHF6, PIK3R1, PMS1, PMS2, POLD1, POLE, POT1, PPM1D, PPP2R2A, PRDM1, PRDM9, PRKAR1A, PSMB10, PSMB8, PSMB9, PTCH1, PTEN, PTPRT, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RASA1, RASA2, RB1, RBM10, RECQL4, RNASEH2A, RNASEH2B, RNASEH2C, RNF43, RPA1, RPL22, RPL5, RUNX1, RUNX1T1, SDHA, SDHB, SDHC, SDHD, SETD2, SLX4, SMAD2, SMAD4, SMARCA4, SMARCB1, SOCS1, SOX9, SPEN, STAG2, STAT1, STK11, SUFU, TAP1, TAP2, TBX3, TCF7L2, TET2, TGFBR2, TMEM132D, TNFAIP3, TNFRSF14, TP53, TP63, TPP2, TSC1, TSC2, UGT1A1, USP9X, VHL, WT1, XRCC2, XRCC3, ZBTB20, ZFHX3, ZMYM3, ZRSR2.

Copy changes (CNVs) in the following genes: ABCB1, ABL1, ABL2, ABRAXAS1, ACVR1B, ACVR2A, ADAMTS12, ADAMTS2, AKT1, AKT2, AKT3, ALK, AMER1, APC, AR, ARAF, ARHGAP35, ARID1A, ARID1B, ARID2, ARID5B, ASXL1, ASXL2, ATM, ATR, ATRX, AURKA, AURKC, AXIN1, AXIN2, AXL, B2M, BAP1, BARD1, BCL2, BCL2L12, BCL6, BCOR, BLM, BMPR2, BRAF, BRCA1, BRCA2, BRIP1, CARD11, CASP8, CBFB, CBL, CCND1, CCND2, CCND3, CCNE1, CD274, CD276, CDC73, CDH1, CDH10, CDK12, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CIC, CREBBP, CSMD3, CTCF, CTLA4, CTNND2, CUL3, CUL4A, CUL4B, CYLD, CYP2C9, CHD4, CHEK1, CHEK2, DAXX, DDR1, DDR2, DDX3X, DICER1, DNMT3A, DOCK3, DPYD, DSC1, DSC3, EGFR, EIF1AX, ELF3, EMSY, ENO1, EP300, EPCAM, EPHA2, ERAP1, ERAP2, ERBB2, ERBB3, ERBB4, ERCC2, ERCC4, ERRFI1, ESR1, ETV6, EZH2, FAM135B, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAT1, FBXW7, FGF19, FGF23, FGF3, FGF4, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, FLT4, FOXA1, FUBP1, FYN, GATA2, GATA3, GLI3, GNA13, GNAS, GPS2, H3-3A, H3-3B, HDAC2, HDAC9, HLA-A, HLA-B, HNF1A, IDH2, IGF1R, IKBKB, IL7R, INPP4B, JAK1, JAK2, JAK3, KDM5C, KDM6A, KDR, KEAP1, KIT, KLF5, KMT2A, KMT2B, KMT2C, KMT2D, KRAS, LARP4B, LATS1, LATS2, MAGOH, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAP3K4, MAPK1, MAPK8, MAX, MCL1, MDM2, MDM4, MECOM, MEF2B, MEN1, MET, MGA, MITF, MLH1, MLH3, MPL, MRE11, MSH2, MSH3, MSH6, MTAP, MTOR, MUTYH, MYC, MYCL, MYCN, MYD88, NBN, NCOR1, NF1, NF2, NFE2L2, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NRAS, NTRK1, NTRK3, PALB2, PARP1, PARP2, PARP3, PARP4, PBRM1, PCBP1, PDCD1, PDCD1LG2, PDGFRA, PDGFRB, PDIA3, PGD, PHF6, PIK3C2B, PIK3CA, PIK3CB, PIK3R1, PIK3R2, PIM1, PLCG1, PMS1, PMS2, POLD1, POLE, POT1, PPM1D, PPP2R1A, PPP2R2A, PPP6C, PRDM1, PRDM9, PRKACA, PRKAR1A, PTCH1, PTEN, PTPN11, PTPRT, PXDNL, RAC1, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RAF1, RARA, RASA1, RASA2, RB1, RBM10, RECQL4, RET, RHEB, RICTOR, RIT1, RNASEH2A, RNASEH2B, RNF43, ROS1, RPA1, RPS6KB1, RPTOR, RUNX1, SDHA, SDHB, SDHD, SETBP1, SETD2, SF3B1, SLCO1B3, SLX4, SMAD2, SMAD4, SMARCA4, SMARCB1, SMC1A, SMO, SOX9, SPEN, SPOP, SRC, STAG2, STAT3, STAT6, STK11, SUFU, TAP1, TAP2, TBX3, TCF7L2, TERT, TET2, TGFBR2, TNFAIP3, TNFRSF14, TOP1, TP53, TP63, TPMT, TPP2, TSC1, TSC2, U2AF1, USP8, USP9X, VHL, WT1, XPO1, XRCC2, XRCC3, YAP1, YES1, ZFHX3, ZMYM3, ZNF217, ZNF429, ZRSR2.

 

Rearrangements (translocations / fusions) in the following genes: AKT1, AKT2, AKT3, ALK, AR, BRAF, BRCA1, CDKN2A, EGFR, ERBB2, ERBB4, ERG, ESR1, ETV1, ETV4, ETV5, FGFR1, FGFR2, FGFR3, MAP3K8, MET, MTAP, MYB, MYBL1, NOTCH1, NOTCH2, NOTCH3, NRG1, NTRK1, NTRK2, NTRK3, NUTM1, PIK3CA, PIK3CB, PPARG, PRKACA, PRKACB, RAF1, RARA, RELA, RET, ROS1, RSPO2, RSPO3, STAT6, TERT, TFE3, TFEB, YAP1.

    

   Find the record of the test by clicking here