Friday, July 1, 2022

NOTICE: Hereditary Hereditary Colon Cancer studies update

 Dear collaborators, 

Following the guidelines for Hereditary Colon Cancer by NCCN together with the guidelines of the SEOM and the medical literature, we have proceeded to a new update of the studies aimed at Hereditary Colon Cancer, with the following tests:

ü  Hereditary colorectal cancer (Test code 8406/ Nemonic code G14004).

o    Studied genes: APC (MLPA), AXIN2, BMPR1A, CDH1, CHEK2, EPCAM (MLPA), GALNT12, GREM1, MLH1 (MLPA), MSH2 (MLPA), MSH3, MSH6 (MLPA), MUTYH, NTHL1, PMS2 (MLPA), POLD1, POLE, PTEN, RNF43, RPS20, SMAD4, STK11, TP53. Panel NGS (Next Generation Sequencing) + 6 MLPA.

 

ü  Hereditary nonpolyposis colorectal cancer (Test code 8174/ Nemonic code G14006).

o    Studied genes EPCAM (MLPA), MLH1 (MLPA), MSH2 (MLPA), MSH6 (MLPA), PMS2 (MLPA). Panel NGS (Next Generation Sequencing) + 5 MLPA


ü  Hereditary polyposis colorectal basic, cancer (Test code 8409/ Nemonic code G14012).

o    Studied genes: APC (MLPA), MUTYH (MLPA), POLD1, POLE. Panel NGS (Next Generation Sequencing) + 2 MLPA


ü  Hereditary nonpolyposis colorectal cancer extended (Test code 8407/ Nemonic code G14009).

o    Studied genes: APC (MLPA), AXIN2, BMPR1A, CDH1, CHEK2, GALNT12, GREM1 (MLPA), MLH1, MUTYH (MLPA), NTHL1, POLD1, POLE, PTEN, RPS20, SMAD4, STK11, TP53, MSH3, RNF43. Panel NGS (Next Generation Sequencing) + 3 MLPA

Which replaces the hereditary polyposis colorectal cancer (Test code 8175/ Nemonic code G14013), that we offered so far.

If the gene to be studied is not found in any of these panels, consult with the laboratory about the possibility of including it.

Thanking you for the trust you have placed in us, we remain at your disposal for any management or doubt you may have.

Thursday, June 30, 2022

Familial Gastric Cancer (CDH1) NGS, whole blood

Description and Delivery Time Modification

Test code: 1338

Effective update from 04/07/2022




PREVIOUS

NEW
        
      Familial Gastric Cancer (CDH1) NGS, whole blood
     
      Delivery term: 30 days
     
     
      Version of Test: 7
     

        
      FAMILIAL DIFFUSE GASTRIC CANCER · CDH1 · NGS   
     
      Delivery term: 32 days
     
     
      Version of Test: 8
     

   Find the record of the test by clicking here

Wednesday, June 29, 2022

IgE SPECIFIC ANTIBODIES FOR FENTANYL (c372), SERUM

Discontinued temporarily

Test code: 9597
Nemomic code: FENTA

Effective update from 29/06/2022

Dear collaborators,

We inform you that, due to problems in the supply of reagent by the supplier, we are forced to temporarily discontinue the determination IgE SPECIFIC ANTIBODIES FOR FENTANYL (c372), SERUM  from today until a new date.

Sorry for the inconvenience caused, we remain at your disposal for any clarification in this regard.

Tuesday, June 28, 2022

HELICOBACTER PYLORI IgG ANTIBODIES, SERUM

Nemonic code, Method, Reference values and Delivery Time Modification

Test code: 2080
Previous Nemonic code: HPGS
New Nemonic code: HPG

Effective update from 04/07/2022




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NEW
Method: Enzyme Immunoassay

Reference values:
 
Negative : Less than 8 U/mL
Grey Zone : 8 - 12 u/mL
Positive : Greater than 12 U/mL

     
Delivery term: 5 days

     
Version of Test: 8
Method: Chemiluminescence

Reference values:
   
Negative : Less than 0.79 U/mL
Grey Zone : 0.80 - 0.89 u/mL
Positive : Greater than 0.90 U/mL      


Delivery term: 3 days

    
Version of Test: 9

   Find the record of the test by clicking here

Monday, June 27, 2022

Polyposis Colon Cancer (MUTYH) MLPA, whole blood

Description Modification

Test code: 4885

Effective update from 30/06/2022




PREVIOUS

NEW
        
      Polyposis Colon Cancer (MUTYH) MLPA, whole blood
     
      Version of Test: 1
     

        
      HEREDITARY POLYPOSIS COLON CANCER · MUTYH · MLPA   
     
      Version of Test: 2
     

   Find the record of the test by clicking here

Polyposis Colon Cancer (APC, MUTYH) NGS, total blood

Description and Delivery Time Modification

Test code: 3785

Effective update from 30/06/2022




PREVIOUS

NEW
        
      Polyposis Colon Cancer (APC, MUTYH) NGS, total blood
     
      Delivery term: 32 days
     
     
      Version of Test: 7
     

        
      POLYPOSIS COLORECTAL CANCER · APC, MUTYH · NGS   
     
      Delivery term: 42 days
     
     
      Version of Test: 8
     

   Find the record of the test by clicking here

Polyposis Colon Cancer (MUTYH) sequencing, total blood

Description and Delivery Time Modification

Test code: 1087

Effective update from 30/06/2022




PREVIOUS

NEW
        
      Polyposis Colon Cancer (MUTYH) sequencing, total blood
     
      Delivery term: 32 days
     
     
      Version of Test: 3
     

        
      HEREDITARY POLYPOSIS COLON CANCER · MUTYH · NGS   
     
      Delivery term: 22 days
     
     
      Version of Test: 4
     

   Find the record of the test by clicking here

BIOAVAILABLE TESTOSTERONE

Method Modification

Test code: 1530

Effective update from 27/06/2022




PREVIOUS

NEW
        
      Radioimmunoassay
     
     
      Version of Test: 10
     

        
      Calculation   
         
               
      Version of Test: 11
     

   Find the record of the test by clicking here

Thursday, June 23, 2022

Benzociadepines Toxicity leves

Reference values Modification

Effective update from 28/06/2022


*Schulz et al. Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Critical Care 2012 16:R136.

Test code

Nemonic code

Description

Previous

New

2349

ALPR

ALPRAZOLAM (TRANKIMAZIN), SERUM

Therapeutic level: 5 - 50 µg/L
Toxicity: Higher than 100 µg/L
Limit of quantification: 2 µg/L

Therapeutic level: 5 - 50 µg/L
Toxicity: 100 - 400  µg/L
Limit of quantification: 2 µg/L

1737

BRO

BROMAZEPAM, SERUM

Therapeutic level: 50-200 µg/L 
Toxicity: Higher than 300 µg/L  (Higher than 2000 µg/L Lethal)
Limit of quantification: 10 µg/L

Therapeutic level: 50-200 µg/L 
Toxicity:  300 - 400  µg/L  (Higher than 2000 µg/L Lethal)
Limit of quantification: 10 µg/L

745

DIA

DIAZEPAM (VALIUM), SERUM

Therapeutic level: 100 - 2500 µg/L 
Toxicity: Higher than 3000 µg/L
Limit of quantification: 25 µg/L

Therapeutic level: 100 - 2500 µg/L 
Toxicity: 3000 - 5000 µg/L
Limit of quantification: 25 µg/L

5112

FLURO

Flurazepam, SERUM

Therapeutic level: 20 - 100 µg/L
Toxicity: Higher than 200 µg/L (Higher than 800 µg/L Lethal)
Limit of quantification: 3 µg/L

Therapeutic level: 20 - 100 µg/L
Toxicity: 200 - 500  µg/L (Higher than 800 µg/L Lethal)
Limit of quantification: 3 µg/L

835

LORA

LORAZEPAM, SERUM

Therapeutic level: 20 - 250 µg/L
Toxicity: Higher than 300 µg/L
Limit of quantification: 5 µg/L

Therapeutic level: 20 - 250 µg/L
Toxicity: 300 -500 µg/L
Limit of quantification: 5 µg/L

1575

NITRZ

NITRAZEPAM, SERUM

Therapeutic level: 30 - 100 µg/L
Toxicity: 200 µg/L
Limit of quantification: 20 µg/L

Therapeutic level: 30 - 100 µg/L
Toxicity: 200 - 300 µg/L
Limit of quantification: 20 µg/L

8671

OXAZ

OXAZEPAM, SERUM

Therapeutic level: 200-1500 µg/L   Limit of quantification: 25 µg/L

Therapeutic level: 200 - 1500 µg/L
Toxicity: 2000 µg/L (3000 - 5000 µg/L Lethal)
Limit of quantification: 25 µg/L

1301

ZOLPID

ZOLPIDEM, SERUM

80 - 150 µg/L
LOQ: 12 µg/L

80 - 150  µg/L
Toxicity: 500 µg/L
Limit of quantification: 12 µg/L

TESTOSTERONE, SERUM

Reference values Modification

Test code: 244

Effective update from 27/06/2022




PREVIOUS

NEW
        
      Men:
      Less than 1 year old: 0.087 - 2.99 ng/mL
      1 - 8 years old: Less than 0.36 ng/mL
      9 - 15 years old: Less than 6.32 ng/mL
      16 - 20 years old: 1.48 - 7.94 ng/mL
      21 - 49 years odl: 2.40 - 8.70 ng/mL
      Greater than or equal to 50 years old: 2.21- 7.16 ng/mL
     
      Women:
      Less than 1 year old: Less than 0.62 ng/mL
      1 - 8 years old: Less than 0.62 ng/mL
      9 - 15 years old: Less than 0.44 ng/mL
      16 - 20 years old: 0.14 - 0.49 ng/mL
      21 - 49 years old: 0.14 - 0.53 ng/mL
      Grater than or equal to 50 years old: 0.12 - 0.36 ng/mL
     
      Reference values depending on the Tanner Stages (pubertal age):
      Men:
      I : 0.02 - 0.23 ng/mL
      II : 0.05 - 0.70 ng/mL
      III: 0.15 - 2.80 ng/mL
      IV : 1.05 - 5.45 ng/mL
      V : 0.65 - 8.00 ng/mL
      Women:
      I : 0.02 - 0.10 ng/mL
      II : 0.05 - 0.30 ng/mL
      III: 0.10 - 0.30 ng/mL
      IV : 0.15 - 0.40 ng/mL
      V : 0.10 - 0.40 ng/
      * Fuente: PNT, Insert
     
      Version of Test: 9
     

        
     Men:
      Less than 1 year old: 0.087 - 2.99 ng/mL
      1 - 8 years old: Less than 0.36 ng/mL
      9 - 15 years old: Less than 6.32 ng/mL
      16 - 20 years old: 1.48 - 7.94 ng/mL
      21 - 49 years odl: 2.40 - 8.70 ng/mL
      Greater than or equal to 50 years old: 2.21- 7.16 ng/mL
     
      Women:
      Less than 1 year old: Less than 0.62 ng/mL
      1 - 8 years old: Less than 0.62 ng/mL
      9 - 15 years old: Less than 0.44 ng/mL
      16 - 20 years old: 0.14 - 0.49 ng/mL
      21 - 49 years old: 0.14 - 0.53 ng/mL
      Grater than or equal to 50 years old: 0.12 - 0.36 ng/mL
     
      Reference values depending on the Tanner Stages (pubertal age):
      Men:
      I : Less or equal than 0.30 ng/mL
      II : Less or equal than 2.78 ng/mL
      III: 0.09 - 6.55 ng/mL
      IV : 0.20 - 7.54 ng/mL
      V : 0.17 - 9.02 ng/mL
      Women:
      I : Less or equal than 0.32 ng/mL
      II : 0.05 - 0.22 ng/mL
      III: 0.07 - 0.41 ng/mL
      IV : 0.15 - 0.54 ng/mL
      V : 0.17 - 0.99 ng/mL
      * Fuente: PNT, Insert    
         
        Version of Test: 10
     


   Find the record of the test by clicking here

FLUNITRAZEPAM (ROHYPNOL) , SERUM

Reference values Modification

Test code: 2006
Nemonic code: FLUNS

Effective update from 28/06/2022




PREVIOUS

NEW
        
      Therapeuric levels: 6 - 15 µg/L
      Toxic levels : > 50 µg/L
      LOD/LOQ: 5 µg/L
     
     
      Version of Test: 6
     

        
     Therapeuric levels: 5 - 15 µg/L
     Toxic levels : Higher than 50 µg/L
     LOQ: 2 µg/L   
         
*AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011, Pharmacopsychiatry 2011, 44, 195-235.     
      Version of Test: 7
     


   Find the record of the test by clicking here