ESTROBALANCE - ESTROGEN METABOLITES

Test Reactivation. Profile Composition, Method and Reference Values Modification

Test code: 4754
Mnemonic code: MESO

Effective update from 21/10/2024

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Method: Enzyme Immunoassay    Reference Values (*):     2-OH estrone + 2-OH estradiol:   Follicular Phase  : 3.4 - 22.8 ng/mg creat.   Ovulatory Phase   : 4.0 - 43.4 ng/mg creat.   Luteal Phase      : 7.9 - 28.5 ng/mg creat.   Postmenopause     : 3.5 - 7.5 ng/mg creat.   With TSH treatment: 0.3 - 76.1 ng/mg creat.   16-alpha-OH estrone   Follicular Phase  : 1.3 - 18.2 ng/mg creat.   Ovulatory Phase   : 4.7 - 25.7 ng/mg creat.   Luteal Phase      : 4.6 - 24.2 ng/mg creat.   Postmenopause     : 2.0 - 5.8 ng/mg creat.   With TSH treatment: 3.4 - 21.2 ng/mg creat.   2/16 RATIO:   Follicular Phase  : 0.7 - 2.61   Ovulatory Phase   : 0.9 - 2.44   Luteal Phase      : 0.68 - 2.22   Postmenopause     : 1.12 - 1.94   With TSH treatment: 1.25 - 4.25   Optimal value for premenopause and postmenopause: > 2 (*)Reference values indicated in the attached report       Version of Test: 16

Method: LC-MS/MS   Reference Values (*):   2-OH estrone:   Women < 55 years: 0.4 – 42.8 ng/mg creat.   Women > 55 years: 0.6 – 4.2 ng/mg creat.   Men             : 0.2 – 6.4 ng/mg creat.   16-alpha-OH estrone   Women < 55 years: 0.3 – 20.5 ng/mg creat.   Women > 55 years: 0.1 – 1.6 ng/mg creat.   Men             : 0.2 – 3.4 ng/mg creat.   2/16 RATIO:   Women < 55 years: > 0.3   Women > 55 years: > 1.9   Men             : > 0.3 (*) Reference values indicated in the attached reportS        Version of Test: 17

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Light Chains Neurofilaments, Serum

Description, Sample, Sample Conservation, Method and Reference values Modification

Test code: 8745

Mnemonic code: NFLSU

Effective update from 28/10/2024

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Description: LIGHT CHAINS NEUROFILAMENTS, SERUM  Sample: Refrigerated serum  Method: Single Molecular Array (SIMOA)  Reference Values:  < 30 years: Less than 9.9 pg/mL  30 - 50 years: Less than 17.5 pg/mL  51 - 60 years: Less than 23.3 pg/mL  61 - 70 years: Less than 30.9 pg/mL  71 - 80 years: Less than 41.3 pg/mL  > 81 years: Less than 54.9 pg/mL                   Version of Test: 7

Description: LIGHT CHAINS NEUROFILAMENTS, PLASMA  Sample: Frozen Plasma-EDTA (14 days stability) *Pre-analytical protocol: After sample collection, centrifuge within 3 hours if the sample is kept at room temperature, or within 24 hours if refrigerated (2-10°C). Transfer the plasma to a polypropylene tube and freeze immediately. Send frozen.  Method: Chemiluminescence    Reference Values:   18-29 years: Less than 9.4 pg/mL  30-39 years: Less than 9.6 pg/mL  40-49 years: Less than 13.3 pg/mL  50-59 years: Less than 21.2 pg/mL  60-69 years: Less than 28.1 pg/mL  70-90 years: Less than 46.8 pg/mL  *Source: Insert - Bibliography Simrén J, et al. Brain Communications 2022    Version of Test: 8

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Light Chains Neurofilaments, CSF

Sample Conservatopm. Method, Reference values and Delivery Time Modification

Test code: 8746
Mnemonic code:  NFLLC

Effective update from 28/10/2024

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Sample Conservation: Refrigerated CSF  Method: Enzyme Immunoassay   Reference Values:  < 30 years: Less than 289 pg/mL  31 - 40 years: Less than 379 pg/mL  > 41 years: Less than 829 pg/mL        Delivery Time: 19 days       Version of Test: 8	Sample Conservation: Frozen CSF (2 months stability)  *Send it in polypropylene tube  Method: Chemiluminescence  Reference Values:  Under 30 years: Less than 380 pg/mL  30-39 years: Less than 560 pg/mL  40-59 years: Less than 890 pg/mL  60 years or older: Less than 1850 pg/mL  *Source: Insert  Delivery Time: 12 days       Version of Test: 9

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FACTOR II TUMORAL NECROSIS (TNF- alfa) , SERUM

Test Reactivation. Method, Reference values and Delivery Time Modification

Test code: 2262

Mnemonic code: TNFA

Effective update from 28/10/2024

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Method: Enzyme Immunoassay        Reference Values:       4.6 pg/mL - 12.4 pg/mL       * Source: PNT, Insert             Delivery term: 7 days                   Version of Test: 11	Method: Chemiluminescence                                Reference Values:       Less than or equal to 13.7 pg/mL       *Source: Insert         Delivery term: 5 days                   Version of Test: 12

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LIGHT CHAINS KAPPA/LAMBDA, URINE

Test Reactivation. Result Format, Method, References Values and Delivery Time Modification

Test code: 2063
Mnemonic code: QCLO

Effective update from 23/10/2024

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Method: Nephelometry   Result Format:  Light Chains KAPPA : R1 mg/L  Light Chains LAMBDA : R2 mg/L  RATIO KAPPA/LAMBDA : R3   Reference Values  Light Chains KAPPA : < 7 mg/L  Light Chains LAMBDA : < 5 mg/L  RATIO KAPPA/LAMBDA : 0.75 - 4.5  *Source: Insert  Delivery Time: 1 day              Version of Test: 10	Method: Turbidimetry             Result Format:  Light Chains KAPPA : R1 mg/L  Light Chains LAMBDA : R2 mg/L  Reference Values  Light Chains KAPPA : Less than 9 mg/L  Light Chains LAMBDA : Less than 7 mg/L  *Source: Insert  Delivery Time: 3 days                Version of Test: 11

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VASCULAR ENDOTHELIAL GROWTH FACTOR TYPE A (VEGF-A), PLASMA

Test Reactivation

Test code: 1232
Mnemonic code: VEGF

Effective update from 21/10/2024

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LIGHT CHAINS KAPPA/LAMBDA- SERUM

Test Reactivation. Method Modification

Test code: 2062
Mnemonic code: QCLS

Effective update from 18/10/2024

PREVIOUS	NEW
Method: Nephelometry                     Version of Test: 6	Method: Turbidimetry                              Version of Test: 7

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ALPHA-1 ANTITRYPSIN · SERPINA1· MLPA

New Test in NOÛS Catalog

Test Code: 10111

Sample:	Biological Sample (EDTA Whole blood 4 mL)
Conservation:	Refrigerated
Method:	Multiplex Ligation-dependent Probe Amplification-MLPA
Set Up Days:	Daily
Delivery term:	22 days

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MYOCARDIOPATHIES COMPLETE PANEL · NGS

New Test in NOÛS Catalog

Test Code: 10110

Sample:	Biological Sample (EDTA Whole blood 4 mL)
Conservation:	Refrigerated
Method:	Next Generation Sequencing (NGS)
Set Up Days:	Daily
Delivery term:	42 days
Information:

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TEMPORARILY DISCONTINUED TESTS LIGHT CHAINS KAPPA/LAMBDA, SERUM AND URINE

Test code: 2062, 2063

Mnemonic code: QCLS, QCLO

Effective update from 16/10/2024

Dear colleagues and collaborators,

We inform you that, due to manufacturing problems with one of the reagents, we are obliged to temporarily discontinue, as of today, the 2062 - LIGHT CHAINS KAPPA/LAMBDA, SERUM and 2063 - LIGHT CHAINS KAPPA/LAMBDA, URINE tests.

We are working to resolve the problem as soon as possible, but currently we do not have a reactivation date for these tests. On the other hand, we also do not have an estimated release date for pending results.

As for the samples already received, the corresponding protocols have been established to guarantee the stability of the samples and ensure the quality of the results.

Given the situation, we kindly ask you to avoid sending new samples until further notice and to extend this information to all your customers.

We will keep you informed of any new developments,

We remain at your disposal for any questions or queries,

Kind regards,

Equipo B2B Customer Care

SYNLAB Diagnósticos Globales S.A.U.

E-Mail:	customer.care@synlab.es
Web:	www.synlab.es

MALONDIALDEHYDE, PLASMA

Delivery Time Modification

Test code: 3045
Mnemonic code: Does not apply

Effective update from 21/10/2024

PREVIOUS	NEW
Delivery term: 7 days	Delivery term: 6 days

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PHARMACOGENETIC STUDIES

Description Modification


Effective update from 18/10/2024

Código	Código Nemónico	ANTERIOR	ACTUAL
8986	G18014	CISPLATIN TOXICITY · TPMT · HOT SPOT	CISPLATIN, RESPONSE TO · TPMT · HOT SPOT
8862	G18010	5-FLUOROURACIL TOXICITY · DPYD · HOT SPOT	FLUOROPYRIMIDINES, RESPONSE TO · DPYD · HOT SPOT
9566	G18016	TOXICITY TO IRINOTECAN · UGT1A1 · HOT SPOT	IRINOTECAN, RESPONSE TO · UGT1A1 · HOT SPOT
10057	G18019	MAVACAMTEN TOXICITY · CYP2C19 · HOT SPOT	MAVACAMTEN, RESPONSE TO · CYP2C19 · HOT SPOT
8984	G18012	METOTREXATE TOXICITY · MTHFR · HOT SPOT	METOTREXATE, RESPONSE TO · MTHFR · HOT SPOT
9774	G18017	WARFARIN TOXICITY · CYP2C9, VKORC1 · HOT SPOT	WARFARIN, RESPONSE TO · CYP2C9, VKORC1 · HOT SPOT

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ALPHA-THALASSEMIA · HBA1, HBA2 · PCR-HYBRIDIZATION

Delivery Time Modification

Test code: 2760
Código nemónico: TALAA

Effective update from 14/10/2024

Dear colleagues and collaborators,

On October 4, the modification of the deadline for test 2760 -  ALPHA-THALASSEMIA · HBA1, HBA2  ·  PCR-HYBRIDIZATION, effective today, Monday, October 14th.

In this publication, a delivery term of 10 days was indicated.

As of today, October 14th, this information has been corrected, indicating the correct delivery term: 15 days.

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