Thursday, February 28, 2019

Oxcarbazepine Metabolite, Serum

Description Modification

Test code: 7630

Effective update from 28/02/2019



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      Oxcarbazepine Metabolite, Serum

        
   OXCARBAZEPINE + 10-OH CARBAZEPINE, SERUM      
         
         
         

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Tuesday, February 26, 2019

VIGABATRIN, SERUM

Sample, Method, Units, Reference Values Modification

Test code: 2438

Effective update from 28/02/2019




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      Sample type: Refrigerated Serum
      Method: High Performance Liquid Chromatography
      Units: µg/mL
        2 - 14 µg/mL (level before next dose)
      
     

        
Sample type: Frozen Serum    Method: Liquid Chromatography/Triple 
        Quadrupole Mass Spectrometry 
Units: mg/L
      2 - 10 mg/L
     

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ERROR- Oxcarbazepine Metabolite, Serum

ERROR: Sample, Method and Reference values Modification

Test code: 7630

Effective update from 28/02/2019


Correct reference values for this test are the indicated below:




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      Sample type: Refrigerated Serum
      Method: High Performance Liquid Chromatography
      
 10-Hydroxycarbazepine:     13 - 30 mg/L
     

      
     

        
Sample type: Frozen Serum      
Method: Liquid Chromatography/Triple 
        Quadrupole Mass Spectrometry  

10-Hydroxycarbazepine:      5 - 30 mg/L
            
Oxcarbazepine:             0.4 - 2 mg/L     
     
*NOTE: Oxcarbazepine is rapidly eliminated from serum, with an apparent half-life of 1.3 to 2.3 hours.
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LEVETIRACETAM (KEPRA), SERUM

Reference values, Units and Method Modification

Test code: 3197

Effective update from 28/02/2019



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      Method: Gas Chromatography 

      Units: µg/mL  
      5 - 30 µg/mL  

Method: Liquid Chromatography/Triple Quadrupole Mass Spectrometry
Units: mg/L        
                   10 – 43 mg/L
Toxicity: Greater than 400 mg/L 
       

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GABAPENTIN, SERUM

Reference values, Sample and Method Modification

Test code: 2793

Effective update from 28/02/2019




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      Sample type: Refrigerated Serum
      Method: High Performance Liquid Chromatography 

       2 - 10 mg/L
      

Sample type: Frozen Serum      
Method: Liquid Chromatography/Triple 
        Quadrupole Mass Spectrometry

                  0.5 - 6 mg/L  
Toxicity: Greater than 85 mg/L

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LAMOTRIGIN , SERUM

Sample and Method Modification

Test code: 2416

Effective update from 28/02/0219




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      Sample type: Refrigerated Serum
      Method: High Performance Liquid Chromatography
     
     

        
     Sample type: Frozen Serum      
     Method: Liquid Chromatography/Triple 
             Quadrupole Mass Spectrometry  
     
     

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PRIMIDONE, SERUM

Sample and Method Modification

Test code: 403

Effective update from 28/02/2019




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      Sample type: Refrigerated Serum
      Method: High Performance Liquid Chromatography
     

        
     Sample type: Frozen Serum      
     Method: Liquid Chromatography/Triple 
             Quadrupole Mass Spectrometry  
     

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ETHOSUXIMIDE (ZARONTIN), SERUM

Sample and Method Modification

Test code: 347

Effective update from 28/02/2019




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      Sample type: Refrigerated Serum
      Method: High Performance Liquid Chromatography
     

        
     Sample type: Frozen Serum      
     Method: Liquid Chromatography/Triple 
             Quadrupole Mass Spectrometry   
         
  

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EVEROLIMUS, TOTAL BLOOD

Reference values, Units, Method and Delivery Time Modification

Test code: 1503

Effective update from 01/03/2019




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       Method: Particle homogeneous immunoassay      
       Units: µg/L   
      
       3 - 8 µg/L

      * Fuente: PNT, Insert

      Delivery term: 3 days
     

 Method: Liquid Chromatography/Tandem Mass Spectrometry 
 Units: ng/mL       
  
 Triple immunossuppressive therapy with
 cyclosporine A and corticosteroids in kidney
 transplant: 
3-8 ng/ml         
  

     
 Delivery term: 4 days
     

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CYCLOSPORIN, WHOLE BLOOD

Method, Reference values and Delivery Time Modification

Test code: 945

Effective update from 01/03/2019




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   Method: Enzyme multiplied immunoassay technique 
     
   RENAL TRANSPLANT: post-trasplant Time 
   Therapeutic Phase
      1 month 200 - 250 ng/mL
      2 - 3 months 175 - 200 ng/mL
      3 - 6 months 150 _ 175 ng/mL
      6 -12 months 125 - 150 ng/mL
      > 12 months 100 - 200 ng/mL
     
   LIVER TRANSPLANT : 5 - 6 days 250 - 350 ng/mL
      8 - 14 days 300 - 350 ng/mL
      More than 14 days 200 - 250 ng/mL
      More than 12 months 100 - 200 ng/mL
   HEART TRANSPLANT : 1 - 5 days 250 - 350 ng/mL
      > 14 days 300 - 350 ng/mL
      * Fuente: PNT, Insert
     
      Delivery term: 2 days
     

Method: Liquid Chromatography/Tandem Mass Spectrometry        
         
Post-transplant Therapy

Renal transplant          150-225 ng/mL 
Liver transplant   225-300 ng/mL
Heart transplant   250-350 ng/mL        

Maintenance Therapy

Renal transplant         100-150 ng/mL 
Liver transplant  100-150 ng/mL
Heart transplant  150-250 ng/mL        
      
     
      Delivery term: 4 days
     

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SIROLIMUS - RAPAMYCIN, WHOLE BLOOD

Reference values, Description, Units, Method and Delivery Time Modification

Test code: 2792

Effective update from 01/03/2019



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      SIROLIMUS - RAPAMYCIN, WHOLE BLOOD
      Method: Microparticle enzyme immunoassay 


      Units: µg/L 

      TRIPLE THERAPY: until the 12 month later del 
      transplant.
      2 doses mg/día: 4,50 - 14.00 µg/L
      5 Doses mg/día: 10,00 - 28.00 µg/L
     
      DOUBLE THERAPY: of 4-12 months after 
      transplant.
      6,50 - 15.00 µg/L
     
      MONOTERAPIA: 4 - 12 months after the 
      transplant.
      17,00 - 29.00 µg/L
     
      Note:
      Triple therapy: Cyclosporin, sirolimus and 
      corticosteroides.
      Double therapy: Cyclosporin, sirolimus.
      * Fuente: PNT, Insert
      

      Delivery term: 2 days
     

SIROLIMUS, WHOLE BLOOD
Method: Liquid Chromatography/Tandem Mass 
        Spectrometry   
       
Units: ng/mL

Kidney transplant

Combination with steroids and mycophenolic acid:
5 - 10 ng/mL
Combination with steroids without mycophenolic acid:
8 - 12 ng/mL
Triple therapy with cyclosporine A, corticosteroids and sirolimus:
4 - 12 ng/mL
Dual therapy with corticosteroids and sirolimus:
12 - 20 ng/mL

Liver transplant

Therapy with Cyclosporin A or tracolimus,
sirolimus and, if necessary, corticosteroids:
3 - 6 ng/mL
Sirolimus therapy and, if necessary, coricosteroids:
5 - 8 ng/mL               
     
      Delivery term: 4 days
     

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TACROLIMUS (FK 506), WHOLE BLOOD

Reference values, Method and Delivery Time Modification

Test code: 2729

Effective update from 01/03/2019



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      Method: Microparticle enzyme immunoassay  
      5 - 20 ng/mL
      * Fuente: PNT, Insert
     
      Delivery term: 2
     

        
Method: Liquid Chromatography/Tandem Mass Spectrometry        
         
Post-transplant Therapy

Renal transplant          10-15 ng/mL 
Liver transplant   10-15 ng/mL
Heart transplant   10-18 ng/mL        

Maintenance Therapy

Renal transplant         5-10 ng/mL 
Liver transplant  5-10 ng/mL
Heart transplant  8-15 ng/mL        
      
     
      Delivery term: 4 days
     

   Find the record of the test by clicking here