Oxcarbazepine Metabolite, Serum

Description Modification

Test code: 7630

Effective update from 28/02/2019

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Oxcarbazepine Metabolite, Serum	OXCARBAZEPINE + 10-OH CARBAZEPINE, SERUM

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VIGABATRIN, SERUM

Sample, Method, Units, Reference Values Modification

Test code: 2438

Effective update from 28/02/2019

PREVIOUS	NEW
Sample type: Refrigerated Serum       Method: High Performance Liquid Chromatography       Units: µg/mL         2 - 14 µg/mL (level before next dose)	Sample type: Frozen Serum    Method: Liquid Chromatography/Triple          Quadrupole Mass Spectrometry  Units: mg/L       2 - 10 mg/L

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ERROR- Oxcarbazepine Metabolite, Serum

ERROR: Sample, Method and Reference values Modification

Test code: 7630

Effective update from 28/02/2019

Correct reference values for this test are the indicated below:

PREVIOUS	NEW
Sample type: Refrigerated Serum       Method: High Performance Liquid Chromatography         10-Hydroxycarbazepine:     13 - 30 mg/L	Sample type: Frozen Serum       Method: Liquid Chromatography/Triple          Quadrupole Mass Spectrometry   10-Hydroxycarbazepine:      5 - 30 mg/L              Oxcarbazepine:             0.4 - 2 mg/L            *NOTE: Oxcarbazepine is rapidly eliminated from serum, with an apparent half-life of 1.3 to 2.3 hours.

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LEVETIRACETAM (KEPRA), SERUM

Reference values, Units and Method Modification

Test code: 3197

Effective update from 28/02/2019

PREVIOUS	NEW
Method: Gas Chromatography        Units: µg/mL         5 - 30 µg/mL	Method: Liquid Chromatography/Triple Quadrupole Mass Spectrometry Units: mg/L                            10 – 43 mg/L Toxicity: Greater than 400 mg/L

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GABAPENTIN, SERUM

Reference values, Sample and Method Modification

Test code: 2793

Effective update from 28/02/2019

PREVIOUS	NEW
Sample type: Refrigerated Serum       Method: High Performance Liquid Chromatography         2 - 10 mg/L	Sample type: Frozen Serum       Method: Liquid Chromatography/Triple          Quadrupole Mass Spectrometry                   0.5 - 6 mg/L   Toxicity: Greater than 85 mg/L

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LAMOTRIGIN , SERUM

Sample and Method Modification

Test code: 2416

Effective update from 28/02/0219

PREVIOUS	NEW
Sample type: Refrigerated Serum       Method: High Performance Liquid Chromatography	Sample type: Frozen Serum            Method: Liquid Chromatography/Triple               Quadrupole Mass Spectrometry

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PRIMIDONE, SERUM

Sample and Method Modification

Test code: 403

Effective update from 28/02/2019

PREVIOUS	NEW
Sample type: Refrigerated Serum       Method: High Performance Liquid Chromatography	Sample type: Frozen Serum            Method: Liquid Chromatography/Triple               Quadrupole Mass Spectrometry

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ETHOSUXIMIDE (ZARONTIN), SERUM

Sample and Method Modification

Test code: 347

Effective update from 28/02/2019

PREVIOUS	NEW
Sample type: Refrigerated Serum       Method: High Performance Liquid Chromatography	Sample type: Frozen Serum            Method: Liquid Chromatography/Triple               Quadrupole Mass Spectrometry

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EVEROLIMUS, TOTAL BLOOD

Reference values, Units, Method and Delivery Time Modification

Test code: 1503

Effective update from 01/03/2019

PREVIOUS	NEW
Method: Particle homogeneous immunoassay              Units: µg/L                  3 - 8 µg/L       * Fuente: PNT, Insert       Delivery term: 3 days	Method: Liquid Chromatography/Tandem Mass Spectrometry   Units: ng/mL            Triple immunossuppressive therapy with  cyclosporine A and corticosteroids in kidney  transplant: 3-8 ng/ml                   Delivery term: 4 days

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CYCLOSPORIN, WHOLE BLOOD

Method, Reference values and Delivery Time Modification

Test code: 945

Effective update from 01/03/2019

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Method: Enzyme multiplied immunoassay technique           RENAL TRANSPLANT: post-trasplant Time     Therapeutic Phase       1 month 200 - 250 ng/mL       2 - 3 months 175 - 200 ng/mL       3 - 6 months 150 _ 175 ng/mL       6 -12 months 125 - 150 ng/mL       > 12 months 100 - 200 ng/mL          LIVER TRANSPLANT : 5 - 6 days 250 - 350 ng/mL       8 - 14 days 300 - 350 ng/mL       More than 14 days 200 - 250 ng/mL       More than 12 months 100 - 200 ng/mL    HEART TRANSPLANT : 1 - 5 days 250 - 350 ng/mL       > 14 days 300 - 350 ng/mL       * Fuente: PNT, Insert             Delivery term: 2 days

Method: Liquid Chromatography/Tandem Mass Spectrometry                   Post-transplant Therapy Renal transplant          150-225 ng/mL  Liver transplant   225-300 ng/mL Heart transplant   250-350 ng/mL         Maintenance Therapy Renal transplant         100-150 ng/mL  Liver transplant  100-150 ng/mL Heart transplant  150-250 ng/mL                            Delivery term: 4 days

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SIROLIMUS - RAPAMYCIN, WHOLE BLOOD

Reference values, Description, Units, Method and Delivery Time Modification

Test code: 2792

Effective update from 01/03/2019

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SIROLIMUS - RAPAMYCIN, WHOLE BLOOD       Method: Microparticle enzyme immunoassay        Units: µg/L        TRIPLE THERAPY: until the 12 month later del        transplant.       2 doses mg/día: 4,50 - 14.00 µg/L       5 Doses mg/día: 10,00 - 28.00 µg/L             DOUBLE THERAPY: of 4-12 months after        transplant.       6,50 - 15.00 µg/L             MONOTERAPIA: 4 - 12 months after the        transplant.       17,00 - 29.00 µg/L             Note:       Triple therapy: Cyclosporin, sirolimus and        corticosteroides.       Double therapy: Cyclosporin, sirolimus.       * Fuente: PNT, Insert              Delivery term: 2 days

SIROLIMUS, WHOLE BLOOD Method: Liquid Chromatography/Tandem Mass          Spectrometry            Units: ng/mL Kidney transplant Combination with steroids and mycophenolic acid: 5 - 10 ng/mL Combination with steroids without mycophenolic acid: 8 - 12 ng/mL Triple therapy with cyclosporine A, corticosteroids and sirolimus: 4 - 12 ng/mL Dual therapy with corticosteroids and sirolimus: 12 - 20 ng/mL Liver transplant Therapy with Cyclosporin A or tracolimus, sirolimus and, if necessary, corticosteroids: 3 - 6 ng/mL Sirolimus therapy and, if necessary, coricosteroids: 5 - 8 ng/mL                            Delivery term: 4 days

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TACROLIMUS (FK 506), WHOLE BLOOD

Reference values, Method and Delivery Time Modification

Test code: 2729

Effective update from 01/03/2019

PREVIOUS	NEW
Method: Microparticle enzyme immunoassay         5 - 20 ng/mL       * Fuente: PNT, Insert             Delivery term: 2	Method: Liquid Chromatography/Tandem Mass Spectrometry                   Post-transplant Therapy Renal transplant          10-15 ng/mL  Liver transplant   10-15 ng/mL Heart transplant   10-18 ng/mL         Maintenance Therapy Renal transplant         5-10 ng/mL  Liver transplant  5-10 ng/mL Heart transplant  8-15 ng/mL                            Delivery term: 4 days

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