MOLECULAR STUDY OF CYTOCHROME P450 (CYP450) (MAIN ENZYMES OF THE MICROSOMAL OXIDATIVE INVOLVED IN PHARMACOGENOMIC RESPONSE), SEQUENCING, BIOLOGICAL SAMPLE

New Test in CIC Catalog

Test Code: 4316

Sample:	Whole blood - EDTA (5 ml)
Conservation:	Refrigerated
Method:	Sequencing Method
Set Up Days:	Daily
Plazo de Entrega:	20 days
Information:
The major enzymes responsible for the metabolism of many drugs belong to the family of Cytochrome P450 (CYP450). In humans have been described at least 18 families and 44 subfamilies CYP450 xenobiotic metabolizing of which families CYP1, CYP2 and CYP3 are those that have a greater importance in drug metabolism. Recently revised the route of elimination of the 200 top-selling drugs by prescription and found that about 80% of drugs are metabolized by the families 1, 2 and 3 of CYP450 and make the greatest contribution by CYP3A4 / 5 (37%), CYP2C9 (17%), CYP2D6 (15%), CYP2C19 (10%), CYP1A2 (9%). Many of these enzymes have polymorphisms that cause changes in the expression, activity or selectivity of the enzyme and are reflected in the variety of responses to drugs. Genetic analysis of these polymorphisms in CYP3A4, CYP3A5, CYP2C9, CYP2D6, CYP2C19, and CYP1A2, is essential for the metabolism of many drugs currently used in many different ailments
Links:
OMIM Entry - + 124060 - CYTOCHROME P450, SUBFAMILY I, POLYPEPTIDE 2; CYP1A2
OMIM Entry - - 124010 - CYTOCHROME P450, SUBFAMILY IIIA, POLYPEPTIDE 4; CYP3A4
OMIM Entry - - 124020 - CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 19; CYP2C19
OMIM Entry - - 124030 - CYTOCHROME P450, SUBFAMILY IID, POLYPEPTIDE 6; CYP2D6
OMIM Entry - - 601130 - CYTOCHROME P450, SUBFAMILY IIC, POLYPEPTIDE 9; CYP2C9
OMIM Entry - - 605325 - CYTOCHROME P450, SUBFAMILY IIIA, POLYPEPTIDE 5; CYP3A5

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