HEPATITIS E VIRUS (HEV), DNA, SERUM

Modification Sample 

Test code: 3652

PREVIOUS Sample	CURRENT  Sample
Whole blood Refrigerated	Serum  Frozen  (Alternative sample: plasma-EDTA frozen)

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METANEPHRINE FRACTIONS , PLASM

Modification Method, Units and  Reference Values 

Test code: 3710

PREVIOUS   Method, Units and Reference Values	CURRENT  Method, Units  and Reference Values
LIQUID CHROMATOGRAPHY /  MASS SPECTROPHOTOMETRY Metanephrin   : Less than 0.37 nmol/L Normetanephrin: Less than 0.94 nmol/L	RADIOIMMUNOASSAY Metanephrin   : Less than 90   pg/mL Normetanephrin: Less than 180  pg/mL

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LIDOCAINE CLORHIDRATE, SERUM

Modification  Reference Values 

Test code: 2098

PREVIOUS   Reference Values

CURRENT  Reference Values

Therapeutic level :  1.4 - 6.0  µg/mL Toxic level       :   > 8.0     µg/mL LOD(limit of detectio):        5  µg/L   LOQ(limit of quantification):  50 µg/L

The therapeutic concentrations in the treatment of cardiac   arrhythmia are less than  5 mg/L.                                  The therapeutic concentrations in the case of local  anesthetic are less than 1 mg/L.                                  The therapeutic concentrations in the treatment of    neonatal convulsions are in the area of 3 -6 mg/L.    LOD(limit of detectio):        0.02 mg/L   LOQ(limit of quantification):  0.2 mg/L

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MOLECULAR STUDY PRIMARI DYSTONIA (ANO3, CIZ1,GNAL,THAP1,TOR1A), NEXT GEN SEQUENCING, WHOLE BLOOD

New Test in CIC Catalog

Test Code: 4328

Sample:	Whole blood - EDTA (5 ml)
Conservation:	Refrigerated
Method:	Sequencing Method
Set Up Days:	Daily
Plazo de Entrega:	90 days
Information:
Dystonia is characterized by involuntary, sustained muscle contractions affecting one or more sites of the body, frequently causing twisting and repetitive movements or abnormal postures. The primary dystonias are those with no other neurologic abnormalities. Although all forms of dystonia share the core clinical features of involuntary dystonic dyskinesia, there is not only marked phenotypic but also etiologic heterogeneity. Primary dystonias were originally described as "idiopathic" since no neurophysiologic, neurochemical, or pathologic findings provided clues to the underlying etiology; however, many are now known to have a genetic basis. Isolated dystonia can be caused by mutations in TOR1A (DYT1), THAP1 (DYT6), CIZ1 (DYT23), ANO3 (DYT24), and GNAL (DYT25). With the availability of specific genet next-generation sequencing panels, a large number of patients would benefit from appropiate genetic diagnosis.

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MOLECULAR STUDY PRIMARI DYSTONIA (ANO3, CIZ1,GNAL,THAP1,TOR1A), NEXT GEN SEQUENCING, WHOLE BLOOD

New Test in CIC Catalog

Test Code: 4328

Sample:	Whole blood - EDTA (5 ml)
Conservation:	Refrigerated
Method:	Sequencing Method
Set Up Days:	Daily
Plazo de Entrega:	92 days
Information:
Dystonia is characterized by involuntary, sustained muscle contractions affecting one or more sites of the body, frequently causing twisting and repetitive movements or abnormal postures. The primary dystonias are those with no other neurologic abnormalities. Although all forms of dystonia share the core clinical features of involuntary dystonic dyskinesia, there is not only marked phenotypic but also etiologic heterogeneity. Primary dystonias were originally described as "idiopathic" since no neurophysiologic, neurochemical, or pathologic findings provided clues to the underlying etiology; however, many are now known to have a genetic basis. Isolated dystonia can be caused by mutations in TOR1A (DYT1), THAP1 (DYT6), CIZ1 (DYT23), ANO3 (DYT24), and GNAL (DYT25). With the availability of specific genet next-generation sequencing panels, a large number of patients would benefit from appropiate genetic diagnosis.

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CLOBAZAM , SERUM

Modification Reference values

Test code: 983

PREVIOUS Reference values	CURRENT  Reference values
CLOBAZAM Therapeutic level:                 250 - 450  ng/mL Note: The presence of Norclobazam be assessed only in the case of therapy without Clonazepam. Clobazam and Clonazepam therapy can interfere with both determinations.   NORCLOBAZAM Orientative Therapeutic level: 1000 - 3000 ng/mL	CLOBAZAM Therapeutic level:    200 - 500  ng/mL   Note: The presence of Norclobazam be assessed only in the case of therapy without Clonazepam. Clobazam and Clonazepam therapy can interfere with both determinations.    NORCLOBAZAM Orientative Therapeutic level: 1000 - 3000 ng/mL    * Krapf,FE, Bieger WP,Tiller FW. LaborDatenBuch (1995) Urban & Schwarzenberg, München.

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PARAMIXOVIRUS (MEASLES, PARAINFLUENZA, MUMPS, SYNCYTIAL), BIOLOGICAL SAMPLE

New Test in CIC Catalog

Test Code: 4327

Sample:	Consult CIC
Conservation:	Frozen
Method:	Polymerase chain reaction (LOINC®: PCR)
Set Up Days:	Daily
Plazo de Entrega:	5 days

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BARTONELLA QUINTANA IgM ANTIBODIES, SERUM

Modification Reference values by transcription error

Test code: 4156

PREVIOUS Reference values	CURRENT  Reference values
NEGATIVE: Titer 1/10	NEGATIVE: Titer 1/100

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DOXEPINE, SERUM

Modification Reference values

Test code: 2008

PREVIOUS Reference values	CURRENT  Reference values
Therapeutic level: 150 - 250 ng/mL      Toxic level:    >  500 ng/mL    *Both result and normal values include     DOXEPIN and its metabolit                                             n-DESMETHYLDOXEPIN.	Therapeutic level: 50 - 250 ng/mL      Toxic level:    >  400 ng/mL      *Both result and normal values include      DOXEPIN and its metabolit                                             n-DESMETHYLDOXEPIN.       * F.E.Krapf, W.P. Bieger, F.W. Tiller:       LaborDatenBuch  (1995) Urban & Schwarzenberg, München.

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DIAZEPAM (VALIUM), SERUM

Modification Reference values

Test code: 745

PREVIOUS Reference values	CURRENT  Reference values
Therapeutic level:       Diazepam   : 0.1 - 1   µg/mL       Nordiazepam: 0.1 - 0.5 µg/mL Toxic level:       Diazepam   : > 2   µg/mL       Nordiazepam: > 1.0 µg/mL	TERAPEUTIC LEVEL: 200 - 2000 µg/L TOXIC LEVEL:    Superior a 3000 µg/L    * M.Schulz, A. Schmoldt A. (2003) Therapeutic and Toxid Blood Concentrations of More than 800 Drugs and other xenobiotics. Pharmazie 58 (7): 447-74.

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DISMETHYLCLOMIPRAMINE (NORCLOMIPRAMINE), SERUM

Test Code: 2350

Discontinued for technical reason.

                    We can offer : 799 CLOMIPRAMINE / DISMETHYLCLOMIPRAMINE , SERUM

DESIPRAMINE (NORPRAMINE), SERUM

Test Code: 746

Discontinued for technical reason.

                    We can offer : 365 IMIPRAMINE / DESIPRAMINE, SERUM

NORTRIPTYLINE, SERUM

Test Code: 744

Discontinued for technical reason.

                    We can offer : 281 AMITRIPTYLINE / NORTRIPTYLINE, SERUM 

IMIPRAMINE / DESIPRAMINE, SERUM

Modification Reference values

Test code: 365

PREVIOUS Reference values	CURRENT  Reference values
Therapeutic level: 150 - 250 ng/mL Toxic level      : Greater than 500 ng/mL	Therapeutic level: 30 - 300 µg/L Toxic level      : Greater than 500 µg/L    *Imipramine  metabolizes  partially to  desipramine and both of them are of concern in therapeutic  values. The    therapeutic values    are refer to addition of both metabolites.   * F.E.Krapf, W.P. Bieger, F.W. Tiller: LaborDatenBuch (1995) Urban & Schwarzenberg, München.

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MAPROTILINE, SERUM

Modification Reference values

Test code: 827

PREVIOUS Reference values	CURRENT  Reference values
200 - 600 ng/mL Toxic level: Greater than 1000 ng/mL	Therapeutic level:  100 - 250 ng/mL Toxic level: Greater than 500 ng/mL   * F.E.Krapf, W.P. Bieger, F.W. Tiller: LaborDatenBuch (1995) Urban & Schwarzenberg, München.

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NITRAZEPAM, SERUM

Modification Reference values

Test code: 1575

PREVIOUS Reference values	CURRENT  Reference values
Therapeutic levels: 30 - 70 µg/L Toxic levels      : Greater than 200 µg/L	Therapeutic levels: 30 - 100 µg/L Toxic levels:       Greater than 200 µg/L    * M.Schulz, A. Schmoldt, Pharmazie (2003) 58(7), 447.

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