ITRACONAZOLE AND HYDROXYLATED METABOLITE, SERUM

Modification Method and  Reference Values 

Test code:  1670

PREVIOUS   Method and Reference Values	CURRENT  Method and  Reference Values
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY   Itraconazole:                                     < 250 µg/L Itraconazole + Hydroxyitraconazole: >1000 µg/L Peak(2 -4 hours) Itraconazole                                      < 2000 µg/L Itraconazole + Hydroxyitraconazole: < 6000 µg/L	LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY Itraconazole and Hydroxyitraconazole:   In prophylaxis: - Residual level: greater than 0.5 mg/L   In treatment: - For Candidiasis (peak at 4h): greater than  2 mg / L - For Aspergillosis (peak at 4h): greater than 5.0 mg / L

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