Test code: 1932
Effective update from 13/09/2018
Evaluation: Therapeutic zone (3 hours post-administration): 1-2 mg/L.
Calculation of the inactivation index (I):
I= (C + 0,6) / D
C: Concentration at the third hour expressed in mg/L.
D: Administered dose expressed in mg/kg.
- If I:<0,50..... phenotype of rapid acetylation.
- If I:>0,60..... phenotype of slow acetylation.
The acetylation velocity of a patient can change. It is advisable to repeat the test in plasma the third hour during treatment.
* Fonte: Bula do fabricante
Toxicity: higher than 20 mcg/mL
At 5-6 hours after oral administration
Dose (mg/Kg) Slow acetylator Fast acetylator
4 2,6 - 3,0 less than 1,2
10 higher than 3,0 less than 2,015 7,8 - 12,0 2,5 - 4,9
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