CORONAVIRUS SARS COV-2 IgG ANTIBODIES (CMIA), SERUM

Method, Units, Reference values Modification

Test code: 8568

Effective update from 02/11/2020

Dear collaborators,

Due to the evolution and current knowledge about SARS-Cov-2 virus, serological tests used in the management of this disease should allow healthcare professionals to evaluate not only quantifiable variations in antibody levels over time but also their ability to provide immunity.

 

Synlab's medical indication is to perform tests designed to detect antibodies against 2 antigens of the Spike protein: S1/RBD and S2. Otherwise we would be ignoring the presence of supposedly blocking and protective antibodies. Tests directed to other targets only indicate contact with the virus but not if anti-S antibodies have been generated, which are the important regarding protection and vaccination.

 

For this reason, we are changing the technique used in the serological analysis of SARS- Cov-2 virus IgG. This change means a modification in both units and reference values ​​of the result, which cannot be correlated with previous results of patient samples analized  by different techniques.

PREVIOUS	NEW
Method: Chemiluminescent Microparticle Immuno Assay (CMIA) Units: Index        Negative : Index less than 1.40 Positive : Index equal or greater than 1.40                   Version of Test: 58	Method: Chemiluminescence                 Units: AU/mL Negative : Less than 12.0 AU/mL Grey zone: 12.0 - 15.0 AU/mL Positive : Equal or greater than 15.0 AU/mL                            Version of Test: 59

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Xanthine, urine

Erased test

Effective update from 28/10/2020

Test code: 4694 - Xanthine, urine

Alternative test: 3336 - HYPOXANTHINE, URINE

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DYSLIPIDEMIA - HYPERCHOLESTEROLEMIA AND OTHER DYSLIPIDEMIAS · PANEL · NGS

Studied Genes Modification

Test code: 8459

Effective update from 29/10/2020

PREVIOUS	NEW
Studied genes: ABCA1, ABCG5, ABCG8, ANGPTL3, APOA1, APOA5, APOB, APOC2, APOE, CETP, CREB3L3, GPD1, GPIHBP1, LCAT, LDLR, LDLRAP1, LIPA, LMF1, LPL, MTTP, NPC1L1, PCSK9, SAR1B                     Version of Test: 127	Studied genes: ABCA1, ABCG5, ABCG8, ANGPTL3, APOA1, APOA5, APOB, APOC2, APOE, CETP, CREB3L3, GPD1, GPIHBP1, LCAT, LDLR, LDLRAP1, LIPA, LMF1, LPL, MTTP, PCSK9, SAR1B                          Version of Test: 128

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YERSINIA ENTEROCOLITICA ANTIBODIES, SERUM

Description Modification

Test code: 481

Effective update from 23/10/2020

PREVIOUS	NEW
YERSINIA ENTEROCOLITICA ANTIBODIES, SERUM Res1. Serotype O:3  Res2. Serotype O:9 Res3. Serotype T:1	ANTIBODIES ANTI YERSINIA, SERUM                  Res 1:Y. enterocolítica Serotype O:3 Res 2:Y. enterocolítica Serotype O:9 Res 3: Y. pseudotuberculosis Serotype T:1

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IgE specific antibodies for rape seed (f316)

Erasted test

Effective update from 22/10/2020

Test code: 5262 - IgE specific antibodies for rape seed  (f316)  
 

Discontinued test, for shortages and suspension of supply of the reagent by the manufacturer. 

Coffin-Siris Syndrome, panel NGS, (ARID1A, ARID1B, SMARCA4, SMARCB1, SMARCE1), biological sample

Erasted test

Effective update from 23/10/2020

Test code: 

7369 - Coffin-Siris Syndrome, panel NGS, (ARID1A, ARID1B, SMARCA4, SMARCB1, SMARCE1), biological sample 8641 - COFFIN SIRIS SYNDROME · PANEL · NGS

Alternative test:

8641 - COFFIN SIRIS SYNDROME · PANEL · NGS

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SOLUBLE P-SELECTIN, SERUM

New Test in NOÛS Catalog

Test Code: 8639

Sample:	Serum (1 ml)
Conservation:	Refrigerated
Method:	Enzyme Immunoassay
Set Up Days:	Daily
Delivery term:	20 days

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BiotA200 - FOOD INTOLERANCE + MICROBIOTA

Method and food intolerances studied Modification

Test code: 8073

Effective update from 21/10/2020

PREVIOUS	NEW
Intolerance food method: ImmunoArray Assay Food intolerances that will not be studied with the new methodology:         Alfa lactoalbumin Watercress Ox Boar Tiger nut Ginko biloba Ginseng Guava Polenta Transglutaminases Haddock                    Version of Test: 29	Intolerance food method: Inmunoblot  New food intolerance studied: Canon salad Chestnut bolete and porcini Kale Chia seed Hemp seed Goji berries Marjoram Poppy seed Grape leave Thistle oil                       Version of Test: 30

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CHROMOSOME 5 · PDGFRB(5q33) · FISH

Description Modification

Test code: 5152

Effective update from 21/10/2020

PREVIOUS	NEW
CHROMOSOME  5 · PDGFRB(5q33) · FISH                     Version of Test: 3	CHROMOSOME  5 · PDGFRB(5q32) · FISH                         Version of Test: 4

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Charcot Marie-Tooth Disease type 1A Pressure-sensitive Polyneuropathy - CMT1A/HNPP (PMP22) MLPA, whole blood

Reference Description and Delivery time

Test code: 5362

Effective update from 23/10/2020

PREVIOUS	NEW
Charcot Marie-Tooth Disease type 1A  Pressure-sensitive Polyneuropathy - CMT1A/HNPP (PMP22) MLPA, whole blood Delivery time: 20 days                    Version of Test: 1	CHARCOT MARIE TOOTH TYPE 1A, DISEASE OF · PMP22 · MLPA   Delivery time: 22 days                   Version of Test: 2

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Charcot Marie-Tooth Disease type 1A, CMT1A (PMP22) sequencing, total blood

Reference values Description and Delivery time

Test code: 1044

Effective update from 23/10/2020

PREVIOUS	NEW
Charcot Marie-Tooth Disease type 1A, CMT1A (PMP22) sequencing, total blood Delivery time: 45 days             Version of Test: 1	CHARCOT-MARIE-TOOTH TYPE 1A DISEASE · PMP22 · SANGER         Delivery time: 32 days                          Version of Test: 2

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Mitochondrial DNA (1656Pb) sequencing, total blood

 Description, Delivery time and Method Modification

Test code: 3877

Effective update from 20/10/2020

PREVIOUS	NEW
Mitochondrial DNA (1656Pb) sequencing, total   blood              Delivery time: 82 days  Method: Sequencing    Version of test: 14	Mitochondrial DNA · mtDNA · NGS                        Delivery time: 42 days   Method: NGS    Version of test: 15

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PARVOVIRUS B19 IgM ANTIBODIES (IFA), SERUM

Reference values Modification

Test code: 2643

Effective update from 15/10/2020

PREVIOUS	NEW
NEGATIVE: Titer less than 1/5       * Fuente: PNT, Insert             Version of Test: 8	NEGATIVE: Titer less than 1/4       * Fuente: PNT, Insert                      Version of Test: 9

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EGR1 (5q31) FISH, total blood/bone marrow

Test Description Modification

Test code: 3459

Effective update from 15/10/2020

PREVIOUS	NEW
EGR1 (5q31) FISH, total blood/bone marrow                  Version of Test: 5	CHROMOSOME 5 · EGR1 (5q31), RSP14 (5q33) · FISH              Version of Test: 6

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IMMUNOGLOBULIN IgE-SPECIFIC

Erasted tests

Test code: 6112, 2353, 3448, 3885 y 6104

Discontinued tests, for shortages and suspension of supply of the reagent by the manufacturer. 

Effective update from 14/10/2020

Test Code	Nemonic Code	Allergen IgE específics
6112	C-03	c209 - CHYMOPAPAIN
2353	O207	o207 – Daphnia
3448	F348	f348 – Lichi
3885	G204	G204 - Arrhenatherum elatius (GRASS POLLENS)
6104	W210	w210 - BEETROOT

RENIN (ACTIVITY), PLASMA

Reference values Modification

Test code: 228

Effective update from 09/10/2020

PREVIOUS

NEW

Adults:  Orthostatic position: 0.60 - 4.18 ng/mL/h  Supine position: 0.32 - 1.84 ng/mL/h       * Fuente: PNT, Insert              Version of Test: 19

Adults:  Orthostatic position: 0.60 - 4.18 ng/mL/h  Supine position: 0.32 - 1.84 ng/mL/h * Fuente: PNT, Insert  Pediatrics:        0-2 years: 1,4 – 7,8 ng/mL/h  3-5 years: 1,5 – 3,5 ng/mL/h  6-8 years: 0,8 – 2,0 ng/mL/h          9-11 years: 0,9 – 2,9 ng/mL/h   12-17 years: 1,2 – 2,4 ng/mL/h *Stalker HP, et al: Plasma renin activity in healthy children. J Pediatr 1976;89:256-258                        Version of Test: 20

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