Study of celiac disease : Gliadin IgA/IgG Antibodies

Effective update from 13/10/2021

Dear customers,

After extensive review of the magnitudes that SYNLAB offers for the study of celiac disease, we decided to start a progressive change in the measurement of antibodies A and G against Gliadin.

Studies and guidelines on celiac disease support the use of A and G antibodies against Deaminated Gliadin instead of A and G antibodies against Gliadin, as detailed in the diagnostic sensitivity and specificity data for celiac disease attachments:

 

856- Gliadin IgA Antibody  (AGLIA)

Diagnostic sensitivity: 70.4%

Diagnostic specificity: 97.0%

 

 2086- Gliadin IgA Antibody (AGLIG)

Diagnostic sensitivity: 70.4%

Diagnostic specificity: 80.2%

 

 1236- Deaminated Gliadin IgA Antibody (AGLIDA)

Diagnostic sensitivity: 82.7%

Diagnostic specificity: 98.4%

 

1237- Deaminated Gliadin IgA Antibody (AGLIDG)

Diagnostic sensitivity: 87.8%

Diagnostic specificity: 98.4%

 

From October 13th, magnitudes recommended for the study of celiac disease will include IgA and IgG Antibodies against deaminated Gliadin instead of IgA and IgG Antibodies against Gliadin. For this reason, unless you contact Synlab and tell us otherwise, laboratory will measure IgA or IgG Antibodies against deaminated Gliadin whose test codes are detailed.

 

 We remain at your disposal for any clarification you require.