SYNLAB En: November 2021

Tuesday, November 30, 2021

BIOMARKERS IN SOLID TUMORS · IDH1 (R132), IDH2 (R172) · HOT SPOT

Delivery term Modification

Test code: 8333

Effective update from 02/12/2021

PREVIOUS	NEW
Delivery time: 7 days	Delivery time: 9 days

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APERT SYNDROME - FGFR2 - MUTATIONS S252W, P253R - SEQUENCING

Description and Method Modification

Test code: 7847

Effective update from 02/12/2021

PREVIOUS	NEW
APERT SYNDROME - FGFR2 - MUTATIONS S252W, P253R - SEQUENCING Method: Sequencing Method Version of Test: 19	APERT SYNDROME · FGFR2(p.S252W, p.P253R) · HOT SPOT Method: HOT SPOT Version of Test: 20

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MGMT (promoter) methylation, tissue

Description and Delivery Time Modification

Test code: 3997

Effective update from 02/12/2021

PREVIOUS	NEW
MGMT (promotor) methylation, tissue Delivery term: 20 Version of Test: 8	BIOMARKERS IN SOLID TUMORS · MGMT(PROMOTOR METHYLATION) · METHYLATION Delivery term: 9 days Version of Test: 9

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Monday, November 29, 2021

GLUTATHION PEROXIDASE, WHOLE BLOOD

Discontinued temporarily

Test code: 3049

Nemonic code: GLPR

Dear colleagues and collaborators,

Due to supply problems with the reagent needed to carry out the GLUTATHION PEROXIDASE, WHOLE BLOOD, we are forced to temporarily suspend its availability from now until a new date.

As soon as information is available about the possible date of normalization of the supply, it will be notified by means of a new communication.

We apologize for the inconvenience caused by this situation.

Description Modification

Effective update from 30/11/2021

CODE	OLD DESCRIPTIVE	NEW DESCRIPTIVE
3344	MLL/AF4 t(4;11) screening, total blood/bone marrow	QUANTITATIVE REARRANGEMENT · MLL/AF4 · RT-PCR
4858	E2A/PBX1 t(1;1) qualitative, bone marrow/ whole blood	QUANTITATIVE REARRANGEMENT · TCF3(E2A)/PBX1 · RT-PCR
5163	CBFB/MYH11 inv(16)(p13q22) quantitative, blood/bone marrow	QUANTITATIVE REARRANGEMENT · CBFB/MYH11(inv16) · RT-PCR
7027	AML1/ETO t(8;21) screening, total blood/bone marrow	QUANTITATIVE REARRANGEMENT · RUNX1(AML1)/RUNX1T1(ETO) · RT-PCR
4305	Chronic Myeloid Leukaemia, CML (T315I-BCR/ABL) screening, total blood	CHRONIC MYELOID LEUKEMIA, RESISTANCE TO TYROSINE KINASE INHIBITORS · BCR-ABL1 (T315I) · HOT SPOT
8427	LYMPHOCYTES T CLONALITY - LYMPHOCYTE RECEPTOR T TCR REARRANGEMENT · TCRG · FRAGMENT A.	LYMPHOCYTES T CLONALITY - LYMPHOCYTE RECEPTOR T TCR REARRANGEMENT · TCRG · FRAGMENT A.
7989	HEMATOLOGICAL NEOPLASIAS · CXCR4 · SANGER	WALDENSTRÖM MACROGLOBULINEMIA · CXCR4(S338X) · SANGER

Friday, November 26, 2021

Cystic Fibrosis, panel (50 mutations, polyT-CFTR) screening, whole blood

Description and Mutations analyzed Modification

Test code: 4402

Effective update from 30/11/2021

PREVIOUS

NEW

Cystic Fibrosis, panel (50 mutations, polyT-CFTR) screening, whole blood

Mutations analyzed:

CFTRdele2,3, R334W, R553X, Y1092X(C>A), E60X, R347P, R560T, M1101K, P67L, R347H, 1811+1.6kbA>G, D1152H, G85E, A455E, 1898+1G>A, R1158X, 394delTT, 2143delT, R1162X, 444delA, 2184delA, 3659delC, R117C, 1677delTA, 2347delG, 3849+10kbC>T, R117H, V520F, W846X, S1251N, Y122X, 1717-1G>A, 2789+5G>A, 3905insT, 621+1G>T, G542X, Q890X, W1282X, 711+1G>T, S549R(T>G), 3120+1G>A, N1303K, L206W, S549N, 3272-26A>G, 1078delT, G551D, R1066C, delI507, delF508, A1006E, 1812-1G>A, A561E, 1069delCA, 2869insG, K710X, R709X, 2184insA, 712-1G>T, H199Y, P205S, V232D and the polimorfism IVS8-5T.

Version of Test: 37

Mutation Detection CFTR gen (Cystic Fibrosis)

Mutations analyzed:

CFTRdele2,3, R334W, R553X, Y1092X(C>A), E60X, R347P, R560T, M1101K, P67L, R347H, 1811+1.6kbA>G, D1152H, G85E, A455E, 1898+1G>A, R1158X, 394delTT,

2143delT, R1162X, 444delA, 2184delA, 3659delC, R117C, 1677delTA, 2347delG, 3849+10kbC>T, R117H, V520F, W846X, S1251N, Y122X, 1717-1G>A, 2789+5G>A,

3905insT, 621+1G>T, G542X, Q890X, W1282X, 711+1G>T, S549R(T>G), 3120+1G>A, N1303K, L206W, S549N, 3272-26A>G, 1078delT, G551D, R1066C, I507del, F508del, A1006E, 1812-1G>A, A561E, 2869insG, K710X, R709X, 2184insA, 712-1G>T, H199Y, P205S, V232D and the polymorphism IVS8-5T.

Version of Test: 38

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PML/RAR t(15;17) screening, total blood/bone marrow

Erased test

Test code: 2742

Alternative: 1156 - QUANTITATIVE REARRANGEMENT · PML/RAR · RT-PCR

Effective update from 30/11/2021

IgE specific antibodies for Japanese cypress (t24)

Reference values Modification

Test code: 4738

Effective update from 29/11/2021

PREVIOUS	NEW
NEGATIVE - Class 0 : Less than 0.35 kU/L POSITIVE - Class 1 : 0.35 - 0.70 kU/L - Class 2 : 0.71 - 3.5 kU/L - Class 3 : 3.6 - 17.0 kU/L - Class 4 : 17.1 - 50.0 kU/L - Class 5 : 50.1 - 100.0 kU/L - Class 6 : More than 100.0 kU/L Version of Test: 5	NEGATIVE - Classe 0 : Less than 0.35 kU/L POSITIVE - Class 1 : 0.35 - 0.70 kU/L - Class 2 : 0.71 - 3.59 kU/L - Class 3 : 3.60 - 17.09 kU/L - Class 4 : 17.10 - 50.09 kU/L - Class 5 : 50.10 - 100.0 kU/L - Classe 6 : Sup. a 100.00 kU/L Version of Test: 6

IgE SPECIFIC ANTIBODIES FOR CHYMOPAPAIN (c-209)

Reference values Modification

Test code: 975

Effective update from 29/11/2021

PREVIOUS	NEW
NEGATIVE - Class 0 : Less than 0.35 kU/L POSITIVE - Class 1 : 0.35 - 0.70 kU/L - Class 2 : 0.71 - 3.5 kU/L - Class 3 : 3.6 - 17.0 kU/L - Class 4 : 17.1 - 50.0 kU/L - Class 5 : 50.1 - 100.0 kU/L - Class 6 : More than 100.0 kU/L Version of Test: 5	NEGATIVE - Classe 0 : Less than 0.35 kU/L POSITIVE - Class 1 : 0.35 - 0.70 kU/L - Class 2 : 0.71 - 3.59 kU/L - Class 3 : 3.60 - 17.09 kU/L - Class 4 : 17.10 - 50.09 kU/L - Class 5 : 50.10 - 100.0 kU/L - Classe 6 : Sup. a 100.00 kU/L Version of Test: 6

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Method Modification

Effective update from 29/11/2021

All the tests described below will change their Methodology from the date indicated:

Chemiluminescence -> Chemiluminescent Microparticle Immunoassay (CMIA)

CODE	DESCRIPTION
2140	HOMOCYSTEINE, PLASMA
407	PSA (PROSTATE SPECIFIC ANTIGEN), SERUM
238	T3 TOTAL TRIIODOTHYRONINE, SERUM
239	T4 TOTAL THYROXINE, SERUM
249	THYROID STIMULATING HORMONE (TSH), SERUM
3105	BNP (BRAIN NATRIURETIC POLYPEPTIDE) C-TERMINAL, PLASMA
786	HEPATITIS B SURFACE ANTIBODY (HBs-Ab), SERUM
361	VITAMIN D (25 HYDROXY-CHOLECALCIFEROL), SERUM

Reference Values, Units and Method Modification

Effective update from 29/11/2021

All the tests described below will change their Methodology from the date indicated:

Chemiluminescence -> Chemiluminescent Microparticle Immunoassay (CMIA)

CODE	DESCRIPTION	PREVIOUS UNITS	NEW UNITS	PREVIOUS REFERENCE VALUE	NEW REFERENCE VALUE
711	T3 FREE, SERUM	ng/L	pg/Ml	2.1-4.4 ng/L	1.58-3.91 pg/mL
199	Luteinizing Hormone (LH), serum	UI/L	mIU/mL	Follicular phase: 1.7-15 IU/L Ovulatory peak: 21.9-56.6 IU/L Luteinic phase: 0.6-16.3 IU/L Postmenopause: 14.2-52.3 IU/L Men: 1.2-7.8 IU/L	Men: 0.57-12.07 mIU/mL Women with normal menstruation: Follicular phase: 1.80-11.78 mIU/mL Mid-menstrual cycle peak: 7.59-89.08 mIU/mL Luteal phase 0.56-14.00 mIU/mL Postmenopausal women: Without HRT 5.16-61.99 mIU/mL

Nemonic Code and Reference Values Modification

Effective update from 29/11/2021

CODE	PREVIOUS MNEMOMIC CODE	NEW MNEMOMIC CODE	DESCRIPTION	PREVIOUS REFERENCE VALUE	NEW REFERENCE VALUE
230	RUBG	RUBGD	RUBELLA IgG ANTIBODIES, SERUM	Non-immune: Less than 5.0 IU/mL Undetermined: 5.0 - 9.99 IU/mL Weak immunity: 10 - 15 IU/mL Immune: Greater than 15 IU/mL	Negative: Less than 7 AU/mL Grey zone: 7 - 9.99 AU/mL Positive: Equal to or greater than 10 AU/mL
231	RUBM	RUBMD	RUBELLA IgM ANTIBODIES, SERUM	NEGATIVE: Index less than 0.80 Undetermined: Index between 0.80 - 1.00 POSITIVE: Index greater than 1.00	Negative: Less than 20 AU/mL Grey zone: 20-24.99 AU/mL Positive: Equal to or greater than 25 AU/mL
247	TOXM	TOXMD	TOXOPLASMA GONDII IgM ANTIBODIES, SERUM	Negative: Index less than 0.90 Undetermined: Index between 0.90 - 0.99 Positive: Index greater than or equal to 1.0	Negative: Less than 6 AU/mL Grey zone: 6 - 7.99 AU/mL Positive: Equal to or greater than 8.8 AU/mL
246	TOXO	TOXOD	TOXOPLASMA GONDII IgG ANTIBODIES, SERUM	Negative: Less than 6.4 UI/mL Undetermined: Between 6.4 - 9.9 UI/mL Positive: Greater than or equal to 10.0 UI/mL	Negative: Less than 7.2 AU/mL Grey zone: 7.2-8.79 AU/mL Positive: Greater than or equal to 8.8 AU/mL