ANTI - DNAss ANTIBODIES, SERUM

Modification Methodology and Reference Values

Test code: 2192

PREVIOUS Methodology  and Reference Values	CURRENT Methodology  and Reference Values
Enzyme immunoassay  NEGATIVE  Indix Less than 1.0	Fluoroenzimoinmunoanalisis NEGATIVE : Less than     7 U/mL GREY-ZONE: Between  7 - 10 U/mL POSITIVE : Greater than 10 U/mL

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FASCIOLA HEPATICA (DISTOMATOSIS) ANTIBODIES, SERUM

Modification Reference values

Test code: 367

PREVIOUS Reference values	CURRENT  Reference values
Negative   : Titer Less than     1/80 Grey Zone  : Titer    1/80  a   1/320 POSITIVE   : Titer Greater than 1/320	Negative   : Titer Less than     1/80 Grey Zone  : Titer    1/80  a   1/320 POSITIVE   : Titer Greater than 1/320

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FOLLICLE STIMULATING HORMONE (FSH), SERUM

Modification Reference values

Test code: 169

PREVIOUS Reference values

CURRENT  Reference values

Childs:  0.1 - 3.0  mIU/mL Male  :  2.4 - 19.9 mIU/mL Female:    Follicular phase:  3 - 20  mIU/mL    Ovulatory Peak  :  10 - 25 mIU/mL    Luteinic phase  :  2 - 11  mIU/mL    Menopaquse      : 20 - 125 mIU/mL

MEN: 0.7 - 11.1 mUI/mL WOMEN:    Follicular phase: 2.8  - 11.3 mUI/mL   Follicular phase days 2 and 3: 3.0 - 14 mUI/mL   Average cycle: 5.8 - 21 mUI/mL   Luteinic phase : 1.2 - 9.0 mUI/mL   Postmenopausicas: 21.7 - 153 mUI/mL   Oral contraceptive: Less than 4.9 mUI/mL PEDIATRIC: BOYS:   Cordón: Less than  1.2 mUI/mL   Less than 3 years:  Less than 5.5 mUI/mL   4 - 9 years: Less than 1.9 mUI/mL GIRLS:   Cordon: Less than 0.1 mUI/mL   Less than 3 years: 0.11 - 13.0 mUI/mL   4 - 9 years: 0.11 - 1.6 mUI/mL

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TRYPSIN, SERUM

Modification Reference values

Test code: 413

PREVIOUS Reference values	CURRENT  Reference values
Childs  :  8 - 26 ng/mL Adults  : 10 - 57 ng/mL	NORMAL VALUE: 10 - 57 ng/mL CHRONIC PANCREATITIS: Less than 47 ng/mL ACUTE PANCREATITIS  : 92 - 850 ng/mL TOTAL PANCREATECTOMY: Less than 1,5 ng/mL

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KINEMATIC VISCOSITY, SERUM

New Test in CIC Catalog

Test Code: 4144

Sample:	Serum (5 ml)
Conservation:	Refrigerated
Method:	Viscosity (LOINC®: V)
Set Up Days:	Daily
Plazo de Entrega:	4 days

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MOLECULAR STUDY BLOOM SYNDROME (BLM) SEQUENCING, WHOLE BLOOD

New Test in CIC Catalog

Test Code: 4124

Sample:	Whole blood - EDTA (5 ml)
Conservation:	Refrigerated
Method:	Sequencing Method
Set Up Days:	Daily
Plazo de Entrega:	47 days
Information:
Bloom's syndrome (BS) is a rare human autosomal recessive disorder belonging to a group of 'chromosomal breakage syndromes''. BS is characterized by marked genetic instability, including a high level of sister chromatid exchanges, associated with a greatly increased predisposition to a wide range of cancers commonly affecting the general population. The constant clinical features of BS are proportionate pre- and postnatal growth retardation and cancer predisposition. BS arises through mutations in both copies of the BLM gene. In Ashkenazi Jewish population, the frequency of BS is approximately 1 in 48000. This is due to a founder effect, approximately 1% of the Ashkenazi Jewish population being heterozygous carriers for the blmAsh mutation.
Links:
OMIM Entry - # 210900 - BLOOM SYNDROME; BLM
Orphanet- Bloom syndrome
OMIM Entry - # 210900 - BLOOM SYNDROME; BLM
OMIM Entry - - 604610 - RECQ PROTEIN-LIKE 3; RECQL3

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ESTRIOL TOTAL, SERUM

Modification Methodology and Reference Values

Test code: 164

PREVIOUS Methodology  and Reference Values

CURRENT Methodology  and Reference Values

Radioinmunoassay  Males: Less than a 3 ng/mL  Nonpregnant women: Less than a 3 ng/mL Pregnant  26 Weeks:      18 -  90 ng/mL           30 Weeks:      21 - 110 ng/mL           34 Weeks:      30 - 170 ng/mL           38 Weeks:      54 - 310 ng/mL           42 Weeks:     105 - 340 ng/mL

Enzyme immunoassay  Males: Less than a 3 ng/mL Nonpregnant women: Less than a 3 ng/mL Pregnant:  17 Weeks: 10-27 ng/mL 18 Weeks: 14-51 ng/mL 19 Weeks: 26-52 ng/mL 20 Weeks: 27-53 ng/mL 21 Weeks: 24-66 ng/mL 22 Weeks: 25-58 ng/mL 23 Weeks: 27-70 ng/mL 24 Weeks: 28-75 ng/mL 25 Weeks: 29-84 ng/mL 26 Weeks: 41-105 ng/mL 27 Weeks: 41-110 ng/mL 28 Weeks: 38-127 ng/mL 29 Weeks: 45-146 ng/mL 30 Weeks: 45-160 ng/mL 31 Weeks: 50-170 ng/mL 32 Weeks: 46-175 ng/mL 33 Weeks: 60-180 ng/mL 34 Weeks: 60-190 ng/mL 35 Weeks: 65-200 ng/mL 36 Weeks: 74-210 ng/mL 37 Weeks: 90-234 ng/mL 38 Weeks: 101-288 ng/mL 39 Weeks: 102-306 ng/mL 40 Weeks: 60-325 ng/mL 41 Weeks: 95-280 ng/mL

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NEUROCYSTICERCOSIS (TAENIA SOLIUM) DNA, CSF

New Test in CIC Catalog

Test Code: 4140

Sample:	CSF (2 ml)
Conservation:	Frozen
Method:	Polymerase chain reaction (LOINC®: PCR)
Set Up Days:	Daily
Plazo de Entrega:	5 days

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DEHYDROEPIANDROSTENEDIONE SULFATE (DHEAS), SERUM

Modification Reference values

Test code: 161

PREVIOUS Reference values	CURRENT  Reference values
Females               Males Newborns    1.6 - 3.6 µg/mL       1.6 - 3.6 µg/mL Prepuberty  0.1 - 0.8 µg/mL       0.1 - 0.8 µg/mL Adults:     0.35- 4.3 µg/mL       0.8 - 5.6 µg/mL Pregnancy   0.1 - 0.8 µg/mL                 Menopause   0.1 - 0.8 µg/mL	MEN:   0.8 - 5.6 µg/mL WOMEN: 0.35 - 4,3 µg/mL

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TISSUE POLYPEPTIDE ANTIGEN (TPA), SERUM

Modification Reference values

Test code: 516

PREVIOUS Reference values	CURRENT  Reference values
Up to 95 U/L	Up to 75 U/L

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FREE INSULIN, PLASMA

Modification Sample 

Test code: 1528

PREVIOUS Sample	CURRENT  Sample and Relative information
Serum Refrigerated	Plasma heparin Frozen

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HUMAN GROWTH HORMONE (HGH), SERUM

Modification Reference values and units

Test code: 182

PREVIOUS Reference values	CURRENT  Reference values
Less than 10 µIU/mL Conversion factor: µIU/mL/3 = ng/ml 2ºIS  OMS NIBSC 98/574	MEN  : Less than  9 mUI/L WOMEN: Less than 24 mUI/L

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T4- FREE, SERUM

Modification Reference values

Test code: 240

PREVIOUS Reference values	CURRENT  Reference values
0.8 - 2.4 ng/dL	NORMAL VALUES  : 0.89 - 1.76 ng/dL HYPOTHYROIDISM : Less than 0.89 HYPERTHYROIDISM: Greather than 1.76

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MOLECULAR STUDY MULTIPLE ENDOCRINE NEOPLASIA TYPE 4 - MEN4 (EXONS 1,2 - CDKN1B) SEQUENCING, WHOLE BLOOD

New Test in CIC Catalog

Test Code: 4137

Sample:	Whole blood - EDTA (5 ml)
Conservation:	Refrigerated
Method:	Sequencing Method
Set Up Days:	Daily
Plazo de Entrega:	23 days
Information:
Multiple endocrine neoplasia type 4 (MEN4) is due to mutations in CDKN1B. It has been described in patients with primary hyperparathyroidism without mutations in MEN1 gen. Also it has been asociated with renal angiomyolipoma.
Links:
MEN-4 and other multipl... [Best Pract Res Clin Endocrinol Metab. 2010] - PubMed - NCBI
OMIM Entry - # 610755 - MULTIPLE ENDOCRINE NEOPLASIA, TYPE IV; MEN4
Online Mendelian Inheritance in Man - MULTIPLE ENDOCRINE NEOPLASIA, TYPE IV - Terms NCBO BioPortal
CDKN1B Gene - GeneCards CDN1B Protein CDN1B Antibody
OMIM Entry - - 600778 - CYCLIN-DEPENDENT KINASE INHIBITOR 1B; CDKN1B

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ANDROSTENEDIONE - DELTA-4

Modification Reference values

Test code: 286

PREVIOUS Reference values	CURRENT  Reference values
CHILDS: 0.3 - 0.5 ng/mL Male  : 0.3 - 3.1 ng/mL FEMALE:         Premenopause : 0.21 - 3.08 ng/mL         Postmenopause: 0.0 -  1.00 ng/mL	MALE  : 0.6 - 3.1 ng/mL FEMALE: 0.3-3.3 ng/ml

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