Test code: 983
Effective update from 25/04/16
PREVIOUS |
NEW
|
Clobazam,serum
CLOBAZAM Therapeutic level: 200 - 500 ng/mL
Note: The presence of Norclobazam be assessed only in the case of therapy without Clonazepam.
Clobazam and Clonazepam therapy can interfere with both determinations.
NORCLOBAZAM Orientative Therapeutic level: 1000 - 3000 ng/mL
* Krapf,FE, Bieger WP,Tiller FW. LaborDatenBuch (1995) Urban & Schwarzenberg, München.
* Source: PNT, Insert
|
Clobazam, norclobazam and ratio, serum
. Therapeutic Area:
Clobazam : 30 -
300 µg/L
Norclobazam: 300 - 3000 µg/L
Norclobazam/Clobazam Ratio: Less than 10
. Toxic Concentration:
Clobazam : Higher
to 3000 µg/L
Norclobazam : Higher to 12000 µg/L
. Comment: The Norclobazam/Clobazam ratio may be useful for
information on the drug metabolizing capacity and improve dose adjustment. Very
high ratios (> 25) indicate that the patient is a poor metabolizer of
CYP2C19 (if not taking drugs that induce CYP3A or CYP2C19 inhibitors).
Note: The presence of Norclobazam must be evaluated only if
no Clonazepam therapy because it interferes with the analytical determination.
*Ther Drug Monit. 2013 Feb;35(1):30-47. doi:
10.1097/FTD.0b013e31827ada88.
Clobazam therapeutic drug monitoring: a comprehensive review
of the literature with proposals to improve future studies.
De Leon J, Spina E, Diaz FJ.
* Source: Literature values
|
Find the record of the test by clicking here
No comments:
Post a Comment