Friday, April 22, 2016


Descriptive and Reference values Modification

Test code: 983

Effective update from 25/04/16


CLOBAZAM Therapeutic level: 200 - 500 ng/mL
Note: The presence of Norclobazam be assessed only in the case of therapy without Clonazepam.
Clobazam and Clonazepam therapy can interfere with both determinations.
NORCLOBAZAM Orientative Therapeutic level: 1000 - 3000 ng/mL
* Krapf,FE, Bieger WP,Tiller FW. LaborDatenBuch (1995) Urban & Schwarzenberg, München.
* Source: PNT, Insert

Clobazam, norclobazam and ratio, serum       
. Therapeutic Area:

Clobazam   :  30 -  300 µg/L
Norclobazam: 300 - 3000 µg/L
Norclobazam/Clobazam Ratio: Less than 10

. Toxic Concentration:

Clobazam    : Higher to  3000 µg/L
Norclobazam : Higher to 12000 µg/L

. Comment: The Norclobazam/Clobazam ratio may be useful for information on the drug metabolizing capacity and improve dose adjustment. Very high ratios (> 25) indicate that the patient is a poor metabolizer of CYP2C19 (if not taking drugs that induce CYP3A or CYP2C19 inhibitors).

Note: The presence of Norclobazam must be evaluated only if no Clonazepam therapy because it interferes with the analytical determination.

*Ther Drug Monit. 2013 Feb;35(1):30-47. doi: 10.1097/FTD.0b013e31827ada88.
Clobazam therapeutic drug monitoring: a comprehensive review of the literature with proposals to improve future studies.
De Leon J, Spina E, Diaz FJ.

* Source: Literature values     

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