REFERENCE VALUES MODIFICATION

We inform you as of tomorrow 9th January  2017, the reference values of the following tests have been modified.

TEST CODE	NAME OF TEST	PREVIOUS REFERENCE VALUES	ACTUAL REFERENCE VALUES
163	17-BETA ESTRADIOL, SERUM	Children:                   Less than 30 pg/mL Male:                         Less than 55 pg/mL  Female,                                                                                     Follicular phase:    30 - 200     pg/mL                   Ovulatory peak:    100 - 450    pg/mL                   Luteinic phase:      50 - 250     pg/mL                   Pregnant:               500 - 26600  pg/mL                   Menopause:         Less than 55 pg/mL	Follicular phase: 20-150 pg/mL   Late follicular phase: 40-350 pg/mL   Ovulatory peak: 150-750 pg/mL   Luteinic phase: 30-450pg/mL   Postmenopause: <21 pg/mL   Men: 10-50 pg/mL   Children (1-12 años):5-30 pg/mL   Boys (12-17): 5-45 pg/mL                                Girls (12-17): 24-410 pg/mL
106	ADRENOCORTICOTROPHIC HORMONE (ACTH), PLASMA	Morning:      14 - 64 pg/mL Evening: Less than 30 pg/mL	Less than 46 pg/mL
2119	ALBUMIN , SERUM	Adults:              35-52 g/L Neonates (0-4 days): 28-44 g/L * CALIBRATOR ATTRIBUTABLE TO REFERENCE STANDARD IFCC CRM 470.	Adults:              35-52 g/L
476	ALKALINE PHOSPHATASE, SERUM	Adults: 30-120 U/L 1-30 days     : Men  75-316 U/L - women  48-406 U/L 30 days-1 year: Men  82-383 U/L - women 124-341 U/L 1-3 years     : Men 104-345 U/L - women 108-317 U/L 4-6 years     : Men  93-309 U/L - women  96-297 U/L 7-9 years     : Men  86-315 U/L - women  69-325 U/L 10-12 years   : Men  42-362 U/L - women  51-332 U/L 13-15 years   : Men  74-390 U/L - women  50-162 U/L 16-18 years   : Men  52-171 U/L - women  47-119 U/L	0-365 days: Men: 76-383 U / L; Women: 48-406 U / L 1-10 years: Men: 86-345 U / L; Women: 69-325 U / L 10-13 years: Men: 42-362 U / L; Women: 51-332 U / L 13-15 years: Men: 74-390 U / L; Women: 50-162 U / L 15-18 years: Men: 52-171 U / L; Women: 47-119 U / L Over 18 years:  Men: 30-120 U / L; Women: 30-120 U / L
109	ALPHA-L-FETOPROTEIN (AFP)	Adults   :  Less than  5.72 ng/mL Pregnancy: 15 weeks :  14.2 - 38       ng/mL 16 Weeks :  13.6 - 52.8     ng/mL 17 Weeks :  13  - 72.3      ng/mL 18 Weeks :  8.3 - 74.3      ng/mL 19 Weeks :  23.3 -97.7      ng/mL 20 Weeks :  30.8 -93.8      ng/mL 21 Weeks :  15.5 -127       ng/mL *For the evaluation of Neuronal Tube Defect Risk, the limit must increased at least 1.5 the values  indicated on the table. *For the evaluation of Neuronal Tube Defect Risk, the inferiors  the inferiors limits indicated on the table  of pregnancy must considered	< 10 ng/ml
112	AMYLASE TOTAL (ALPHA AMYLASE), URINE	Men: Less or equal tan 490 U/L Women: Less or equal than 450 U/L	Less than 550 U/L
4268	BETA 2-MICROGLOBULIN, URINE	Less than 370  µg/24 H	30- 370  µg/24 H
1926	BICARBONATE, SERUM	Neonates           : 17 - 24 mmol/L Infants            : 19 - 24 mmol/L 2 months to 2 years: 16 - 24 mmol/L Adults             : 21 - 31 mmol/L	21 - 31 mEq/L
762	CA 125 (TUMOR MARKER), SERUM	Less than 21 U/mL	Less than 35 UI/mL
863	CA 19-9 (TUMOR MARKER), SERUM	Less than 33 U/mL	Less than 37 U/mL
304	CALCITONIN, SERUM	Men: Less than 11.8 pg/mL Women:  Less than 4.8 pg/mL	Men: Less than 8.4 pg/mL Women:  Less than 5 pg/mL
302	CALCIUM TOTAL, URINE	Normal diet (medium)    : 100 - 200     mg/24H Diet low in calcium     : Less than 150 mg/24H Diet rich in calcium    : 240 - 300     mg/24H	100-240 mg/24h
301	CALCIUM, SERUM	Children: 0-10 days        : 7.6 - 10.4 mg/dL 10 days-24 months:   9 - 11.0 mg/dL 2-12 years       : 8.8 - 10.8 mg/dL Adults           : 8.8 - 10.6 mg/dL	8.6-10.2 mg/dL
307	CARBAMAZEPINE, SERUM	Therapeutic level:       4 - 12 µg/mL Toxic levels:  Greather than 15 µg/mL	4-10 μg/ml
127	CARCINOEMBRYONIC ANTIGEN - CEA, SERUM	Non smokers: 0 - 5    ng/mL Smokers    : Up to 10 ng/mL	Less than 5 ng/mL
2926	CHORIONIC GONADOTROPHINS (FREE BETA HCG), SERUM	Male :  Less than 0.3 ng/mL Female: Not pregnant:  Less than 0.3 ng/mL Pregnancy:                                             Media   8  Weeks                   87.49 ng/mL 9  Weeks                   81.84 ng/mL 10 Weeks                   67.17 ng/mL 11 Weeks                   51.95 ng/mL 12 Weeks                   40.49 ng/mL 13 Weeks                   34.19 ng/mL 14 Weeks                   23.52 ng/mL 15 Weeks                   18.80 ng/mL 16 Weeks                   18.33 ng/mL 17 Weeks                   11.02 ng/mL 18 Weeks                   09.19 ng/mL 19 Weeks                   05.21 ng/mL	Men and non pregnant women: <5 mUI/mL Pregnant women: 4 weeks: 5-100 mUI/mL 5 weeks: 200-3.000 mUI/mL 6 weeks: 10.000-80.000 mUI/mL 7-14 weeks: 90.000-500.000 mUI/mL 15-26  weeks: 5.000-80.000 mUI/mL 27-40 weeks: 3.000-15.000 mUI/mL
159	CORTISOL, SERUM	Ext.morning (8H)  : 5 - 25 µg/dL Ext.evening (18H) : 2 - 13 µg/dL	Ext.morning (8H)  : 5 - 23 µg/dL
215	C-PEPTIDE, SERUM	0.8-4 ng/ mL	1.1-4.4 ng/mL
324	CREATININE- SERUM	0.6-1.4 mg/dL	Men 18-60 years: 0.9-1.3 mg / dL Women 18-60 years: 0.6-1.1 mg / dL Men older than 60 years: 0.8-1.3 mg / dL Women older than 60 years: 0.6-1.2 mg / dL Children: 0.3-0.7 mg / dL Adolescents: 0.5-1 mg / dL
325	CREATININE, URINE	Male  :  1500 - 2500 mg/24H Female:  800 -  1500 mg/24H	Male  :  1000 - 2000 mg/24H Female:  800 -  1800 mg/24H
161,  4563, 4564, 4565, 4566, 4567, 4568 4569, 4570, 4571	DEHYDROEPIANDROSTENEDIONE SULFATE (DHEAS), SERUM	MEN:   0.8 - 5.6 µg/mL WOMEN: 0.35 - 4.3 µg/mL	Men: 2.17-15.2 µmol/L Womens: 0.92-11.67 µmol/L
162	DIGOXIN, SERUM	THERAPEUTIC LEVEL: 0.8 - 2.2        ng/mL TOXIC LEVEL      : Greater than 2.4 ng/mL	0.8 - 2.0  ng/mL
4343	FACTOR XA (ANTI ACTIVATED), PLASMA	0,5-1,2 UI/mL	0.5-1.0 U/mL
167	FERRITIN, SERUM	Men: 20-250 ng/mL Women: 10-120 ng/mL Men                : 20-250 ng/mL Women              : 10-120 ng/mL Children: Up to 1 month      : 6-400 ng/mL From 1 to 6 months : 6-410 ng/mL From 6-12 months   : 6-80 ng/mL From 1 to 5 years  : 6-60 ng/mL From 6 to 19 years : 6-320 ng/mL * Calibrator attributable to the 3rd International Standard of ferritin, biotechnology code NIBSC (National Institute for Biological Standards and Control): 94/572.	Men: 20-250 ng/mL Women: 10-120 ng/mL
168	FIBRINOGEN, PLASMA	180-240 mg/dL	200-400 mg/L
169	FOLLICLE HORMONE (FSH), SERUM	MEN: 0.7 - 11.1 mUI/mL WOMEN:   Follicular phase: 2.8  - 11.3 mUI/mL   Follicular phase days 2 and 3: 3.0 - 14 mUI/mL   Average cycle: 5.8 - 21 mUI/mL   Luteinic phase : 1.2 - 9.0 mUI/mL   Postmenopausicas: 21.7 - 153 mUI/mL   Oral contraceptive: Less than 4.9 mUI/mL PEDIATRIC: BOYS:   Cordon: Less than  1.2 mUI/mL	Follicular phase: 1.4-9.9 UI/L Ovulatroy peak: 0.2-17.2 UI/L Luteinic phase: 1.9-9.2 UI/L Postmenopause: 19.3-100.6 UI/L Men: 1.4-15.4 UI/L
358	HAEMOGLOBIN A1C, WHOLE BLOOD	4.7 - 6.4 % 28 - 46 mmol/mol	Less than 48 mmol/mol Prediabetes: 39 - 46  mmol/mol
117	HEPATITIS B IGM CORE ANTIBODIES, SERUM	Not detected	Not detected: Less than 0.8 Undetermined:  0.8-1.0 Positive: Greater than 1.0
786	HEPATITIS B SURFACE ANTIBODY (HBS-AB), SERUM	Active immunization: Greater than 10 mIU/mL	Negative: Less than 10 mIU/mL.L Active immunization: Greater or equal than 10 mIU/mL
2140	HOMOCYSTEINE , PLASMA	Normal                        :    < 15.0   µmol/L Risk Vascular Disease         :    > 15.0   µmol/L Vitamin Deficiency            : 15.0 - 30   µmol/L After Methionine, Heterozygote: 30   - 100  µmol/L                   Homozygote  :    > 100    µmol/L	Younger than 15 years: Less than 10 μmol / L 15-65 years: Less than 15 μmol / L Older than 65 years: Less than 20 μmol / L
193	IMMUNOGLOBULIN - E (IGE) , SERUM	Newborns    : 0 - 1.5 IU/mL 1 year      : 0 - 15  IU/mL 1 - 5 years : 0 - 60  IU/mL 6 - 9 years : 0 - 90  IU/mL 10 -15 years: 0 - 200 IU/mL Adults      : 0 - 100 IU/mL * CALIBRATION WITH REFERENCE STANDARD   IRP 75/502	Adults: Lees than 160 UI/mL
194	IMMUNOGLOBULIN - G (IGG) , SERUM	Newborns       : 660-1750 mg/dL 1- 3 Months    : 200-1050 mg/dL 3- 6 Months    : 220-690  mg/dL 6-12 Months    : 260-950  mg/dL 1-4  years     : 360-1340 mg/dL 4-8  years     : 540-1500 mg/dL 8-12  years    : 630-1550 mg/dL 12-16 years    : 670-1560 mg/dL 16-18 years    : 720-1550 mg/dL Adults         : 700-1600 mg/dL *Proteins in Clinical and Laboratory Medicine, Lothar Thomas MD, English Edition 2008 (Siemens). * CALIBRATOR ATTRIBUTABLE TO REFERENCE STANDARD IFCC CRM 470.	0-1 years: 313-1170   mg/dL                                  2-4 years: 295-1156   mg/dL 5 - 10 years: 386-1682  mg/dL 11-16 years: 503-1719  mg/dL 17-18 years : 487-1327  mg/dL >18 years: 767-1590  mg/dL
195	IMMUNOGLOBULIN - M (IGM) , SERUM	Newborns       : 6 - 21 mg/dL 3-6 months     : 17-100 mg/dL 6-9 months     : 26-130 mg/dL 9-12 months    : males 33-140 mg/dL - female 33-150 mg/dL 1-2  years     : males 37-160 mg/dL - female 40-180 mg/dL 2-4  years     : males 41-160 mg/dL - female 47-190 mg/dL 4-8  years     : males 43-180 mg/dL - female 52-220 mg/dL 8-12 years     : males 47-180 mg/dL - female 60-240 mg/dL 12-16 years    : males 49-190 mg/dL - female 65-260 mg/dL 16-18 years    : males 50-190 mg/dL - female 68-260 mg/dL Adults         : males 40-230 mg/dL - female 40-280 mg/dL *Proteins in Clinical and Laboratory Medicine, Lothar Thomas MD, English Edition 2008 (Siemens). * CALIBRATOR ATTRIBUTABLE TO REFERENCE STANDARD IFCC CRM 470.	0-1 years: 46-152  mg/dL                                 2-4 years: 37-184  mg/dL   5 - 10 years: 37-251 mg/dL 11-16 years: 41-244 mg/dL 17-18 years : 49-201 mg/dL >18 years: 37-286 mg/dL
190	IMMUNOGLOBULIN -A (IGA) , SERUM	Newborns     :  1-6   mg/dL 3-6 months   : 10-60  mg/dL 6-9 months   :  8-80  mg/dL 9-12 months  : 11-90  mg/dL 1-2  years   : 14-150 mg/dL 2-4  years   : 21-190 mg/dL 4-8  years   : 30-250 mg/dL 8-12 years   : 46-290 mg/dL 12-16 years  : 58-310 mg/dL 16-18 years  : 67-320 mg/dL *Adults      : 70-400 mg/dL Proteins in Clinical and Laboratory Medicine, Lothar Thomas MD, English Edition 2008 (Siemens).	0-1 years: 36-79  mg/dL                                2-4 years: 27-246  mg/dL   5 a 10 años: 34-274 mg/dL 11-16  years: 52-319 mg/dL 17-18  years : 60-337 mg/dL >18  years: 61-356 mg/dL
196	IMMUNOGLOBULINS G,A,M , SERUM	IgG(mg/dL)  IgA(mg/dL)  IgM(mg/dL) Newborns       : 600-1350     7- 22      4- 70 1- 3 Months    : 290- 870     10- 40     20- 90 3- 6 Months    : 230- 450     10- 65     30-100 6-12 Months    : 230- 650     20- 90     30-140 1- 3 years     : 330- 900     20-130     45-155 3- 5 years     : 480-1030     35-145     50-155 5- 9 years     : 540-1160     40-160     50-160 9-12 years     : 620-1230     45-175     50-165 12-15 years    : 650-1240     50-205     40-165 Adults:        : 700-1600     70-400     40-230 * CALIBRATION WITH REFERENCE STANDARD   IFCC/BCR/CAP-CRM 470	IgG: 0-1 years: 313-1170   mg/dL                                  2-4 years: 295-1156   mg/dL   5 - 10 years: 386-1682  mg/dL 11-16 years: 503-1719  mg/dL 17-18 years : 487-1327  mg/dL >18 years: 767-1590  mg/dL IgA: 0-1 years: 36-79  mg/dL                                2-4 years: 27-246  mg/dL   5 a 10 años: 34-274 mg/dL 11-16  years: 52-319 mg/dL 17-18  years : 60-337 mg/dL >18  years: 61-356 mg/dL IgM: 0-1 years: 46-152  mg/dL                                 2-4 years: 37-184  mg/dL   5 - 10 years: 37-251 mg/dL 11-16 years: 41-244 mg/dL 17-18 years : 49-201 mg/dL >18 years: 37-286 mg/dL
197	INSULIN, SERUM	5-25 μU/ml	2-25 μU/ml
186	IRON, SERUM	Neonates : 100 - 250 µg/dL Babies   :  40 - 100 µg/dL Children :  50 - 120 µg/dL Man      :  70 - 180 µg/dL Woman    :  60 - 180 µg/dL	60-150 µg/dL
371	LACTATE DEHYDROGENASE (LDH), SERUM	230- 460 U/L (37ºC)	208-378 U/L
202	LIPASE, SERUM	Children under 1 year:   <8 U / L From 1-9 years       : 5-31 U / L From 10 to 18 years  : 7-35 U / L Adults               :  <67 U / L	Less than 67 U/L
199	LUTEINIZING HORMONE (LH), SERUM	MEN: 0.8 - 7.6 mUI/mL WOMEN:   Follicular phase: 1.1  - 11.6 mUI/mL    Average cycle: 17 - 77 mUI/mL   Luteinic phase: Less than 14.7 mUI/mL   Perimenstrual: Less than 12.0 mUI/mL   Postmenopausicas: 11.3 -39.8 mUI/mL   Oral contraceptive: Less than 8.0 mUI/mL PEDIATRIC: BOYS:   Cordon: Less than 3.6 mUI/mL   Less than 1.5 years: Less than 4.1 mUI/mL   1.6-9 years: Less than 3.8 mUI/mL GIRLS:   Cordon: Less than 0.1 mUI/mL   Less than 1.5 years: Less than 2.3 mUI/mL   1.6 - 9 years: Less than 1.3 mUI/mL	Follicular phase: 1.7-15 UI/L Ovulatory peak: 21.9-56.6 UI/L  Luteinic phase: 0.6-16.3 UI/L  Postmenopause: 14.2-52.3 UI/L  Men: 1.2-7.8 UI/L
207	MAGNESIUM, URINE	60-75 mg/24 h	73-122 mg/24 h
872	MICROALBUMINE, URINE	Isolated urine     : Up to  3  mg/dL Urine 24 hours : Up to 16 µg/minuto   * CALIBRATION WITH REFERENCE STANDARD     IFCC/BCR/CAP-CRM 470	Less than 30 mg/24 h
387	MYOGLOBIN, SERUM	Until 70 ng/mL	inferior a 36.4 ng/mL
1019	PARATHYRID HORMONE INTACT (PTH), SERUM	10-73 pg/mL	10-65 pg/mL
439	PHOSPHORUS, URINE	0,3-1,0 g/24h	400-1300 mg/24h
2780	PLASMINOGEN ACTIVITY, PLASMA	70-140%	75-140%
219	POTASSIUM, SERUM	3.6 - 5.5 mEq/L	3.5 - 5.1 mmol/L
222	PROGESTERONE, SERUM	Children: < 1 year:                     0.1 - 17   ng/mL                  1 - 9 years:                0.1 - 1.3  ng/mL  Female:   Follicular phase:      0.1 - 1.5  ng/mL                  Luteinic phase:         2.5 -28.1  ng/mL                  Menopause:             0.1 - 1.0  ng/mL    Oral Anticonceptivs:            0.3 - 0.9  ng/mL    Pregnant  1er Trimonthter:    9.3 - 33.2 ng/mL                      2nd Trimonthter:        29.5 -50.0 ng/mL                      3rd Trimonthter : 83.1 - 160 ng/mL  Male:                                          0.27 -0.90 ng/mL	Normal women: Follicular phase:<0.89 µg/L  Ovulatory peak <12 µg/L Luteinic phase: 1.84-24 µg/L Prepubertal children: <0.35 µg/L Postmenopause: <0.2 µg/L Men: <0.2 µg/L
223, 4644, 4645,4646, 4647, 4648, 4649, 4650, 4651, 4652	PROLACTIN, SERUM	MEN: 2.5- 17 ng/ml WOMEN: 1.9- 25 ng/ml PEDIATRIC:  Cordon: 160-665 ng/ml  Less than 0.5 years: 2-125 ng/ml  0.6-9 years: 1-40 ng/ml	Men     : 3.0 -  14.7 µg/L Women     : 3.8  - 23 µg/L
850	PROTEIN TOTAL , SERUM	66 - 83 g/L	64 - 83 g/L
319	PROTEIN TOTAL , URINE	Spot urine : Less than 10  mg/dL Urine 24 H :  10  -   150 mg/24H	Less than  150 mg/24 h
407	PSA (PROSTATE SPECIFIC ANTIGEN), SERUM	Less than 3 ng/mL	Less than 4 ng/mL
230	RUBELLA IGG ANTIBODIES, SERUM	NEGATIVE      :  Less than  5.0 IU/mL GREY ZONE     :  5.0   -   10 IU/mL POSITIVE      :  Greater than 10.0 IU/mL        * In absence of positive IgM, the 3 levels of positivity   of IgG are indicators of active immunity. * To descard active infection is recommended to do Rubella-IgM. Or seroconversion for IgG Rubella antibody after 2-3 weeks of first sample. Increasing of the   index 2 or more times indicates active infection.	Non-immune: Less than 5.0 IU / mL Undetermined: 5.0 - 9.99 IU / mL Immunity weak: 10 - 15 IU / mL Immune: Greater than 15 IU / mL
547	SEX HORMONE BINDING GLOBULIN (SHBG), SERUM	Childs  : 40 - 90  nmol/L Male    : 10 - 50  nmol/L Female  : 25 - 90  nmol/L Pregnant: 250 -500 nmol/L	Men: 10-57 nmol/L Women:  18-144 nmol/L
235	SODIUM, SERUM	133 - 155 mEq/L	136 - 146 mmol/L
236	SODIUM, URINE	30-260 mEq/24h	40-220 mmol/24h
711	T3 FREE, SERUM	1.8-4.2 pg/mL	2.1-4.4 ng/L
238	T3 TOTAL (TRIIODOTHYRONINE), SERUM	60-181 ng/dL	Children 1-20 years: 0.8-2.1 µg/L Adults 21-50 years: 0.7-2 µg/L Adults 51-90 years: 0.4-1.8 µg/L
240	T4- FREE, SERUM	NORMAL VALUES  : 0.89 - 1.76 ng/dL HYPOTHYROIDISM : Less than 0.89 HYPERTHYROIDISM: Greather than 1.76	Children (1-20  years): 0.8-2 ng/dL Adults: 0.8-2.7 ng/dL
239	T4 TOTAL (THYROXINE), SERUM	4.5 - 12.5 µg/dL	Children (1-15 years): 5.6-11.7 µg/dL Men: 4.6-10.5 µg/dL Women: 5.5-11µg/dL
244	TESTOSTERONE, SERUM	Males: * 20-49 years           :  72 - 853 ng/dL * Greater than 50 years : 129 - 767 ng/dL Females: * Ovulatory phase    :   < 73 ng/dL * Postmenopausal     :   < 43 ng/dL	Males: 1 - 9  years: <0.3 ng/mL Adults:  2.6 - 10 ng/mL Females: 1- 9 years: <0.2 ng/mL Adults: 0.15- 0.7 ng/mL
412	THYROGLOBULIN, SERUM	Less than 55 ng/mL	3-42 ng/mL
248	TRANSFERRIN, SERUM	Adults and children over 10 years: 200-360 mg/dL Children: 0-4 Days:                   130-275 mg/dL 3 months - 10 years: 203-360 mg/dL  * Calibrator traceable to Standard ERM® DA470	200 – 360 mg/dL
249	TSH (THYROID STIMULATING HORMONE), SERUM	0.3 - 5 µU/mL Límite de sensibilidad: 0.01 µU/mL  * CALIBRACION CON ESTANDAR DE REFERENCIA WHO 2nd IRP 80/558	Children 1-20 years: 0.7-6.4 mU/L Adults 21-54 years: 0.4-4.2 mU/L Adults 55-87 years: 0.5-8.9 mU/L Reference values in pregnant women:         - 1st trimester: up to 2.5 mU/L         - 2nd and 3rd trimester: up to 3.5 mU/L
2005	UREA , SERUM	17 - 50 mg/dL	17 - 49 mg/dL
884	UREA, URINE	14-35 g/24h	13-36 g/24h
254	VITAMIN B12 (CYANOCOBALAMINE), SERUM	180-914 pg/mL	206 - 678 pg/mL