Tuesday, May 30, 2017

ISONIAZID, SERUM

Reference values, Sample and Delivery Time Modification

Test code: 1932

Effective update from 31/05/2017




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Refrigerated serum
        
At 5 to 6 h after oral administration:

Dose........Slow acetylator...... Rapid acetylator
(mg/kg)........(µg/mL)...............(µg/mL)
 4............. 2,6-3............... hasta 1,2
 10............ más de 3............ hasta 2
 15.............7,8-12...............2,5-4,9
     
     
Delivery term: 32 days
     

        
 Frozen serum        
         
 Blod drawn shoud be done 3 hours after drug intake. Freezing should be done no more than one hour after blood drawn.

Evaluation: Therapeutic zone (3 hours post-administration): 1-2 mg/L.

Calculation of the inactivation index (I):
I= (C + 0,6) / D 
C: Concentration at the third hour expressed in mg/L. 
D: Administered dose expressed in mg/kg. 

- If I:<0,50..... phenotype of rapid acetylation. 
- If I:>0,60..... phenotype of slow acetylation. 

The acetylation velocity of a patient can change. It is advisable to repeat the test in plasma the third hour during treatment.        
         
        
     
 Delivery term: 8 days
     

   Find the record of the test by clicking here

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