ISONIAZID, SERUM

Reference values, Sample and Delivery Time Modification

Test code: 1932

Effective update from 31/05/2017

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Refrigerated serum          At 5 to 6 h after oral administration: Dose........Slow acetylator...... Rapid acetylator (mg/kg)........(µg/mL)...............(µg/mL)  4............. 2,6-3............... hasta 1,2  10............ más de 3............ hasta 2  15.............7,8-12...............2,5-4,9             Delivery term: 32 days

Frozen serum                    Blod drawn shoud be done 3 hours after drug intake. Freezing should be done no more than one hour after blood drawn. Evaluation: Therapeutic zone (3 hours post-administration): 1-2 mg/L. Calculation of the inactivation index (I): I= (C + 0,6) / D  C: Concentration at the third hour expressed in mg/L.  D: Administered dose expressed in mg/kg.  - If I:<0,50..... phenotype of rapid acetylation.  - If I:>0,60..... phenotype of slow acetylation.  The acetylation velocity of a patient can change. It is advisable to repeat the test in plasma the third hour during treatment.                                   Delivery term: 8 days

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