Test code: 125
Effective update from 22/03/2021
Antithyroid autoantibodies appear when a person's
immune system attacks proteins or other components of the thyroid gland; This
produces a chronic inflammation of the gland (thyroiditis), tissue damage and/or
alteration of the function of the gland. Thyroid autoantibodies detect the
presence and measure the amount of thyroid-specific autoantibodies.
Anti-thyroglobulin (anti-TG) antibody measurements
are used to differentiate subclinical hypothyroidism and hyperthyroidism and to
aid in the diagnosis of Hashimoto's and Graves' autoimmune diseases affecting
the thyroid gland. Furthermore, anti-TG antibodies are detected in 30% –60% of
cases of patients with thyroid carcinoma. In such patients, the likelihood of
the presence of significant concentrations of anti-TG antibodies should be considered
when measuring TG antigen, since the measurement and detection of TG antigen
can be influenced by the presence of anti-TG antibodies.
To help in the diagnosis and monitoring of
autoimmune thyroid diseases and differentiate them from other forms of thyroid
diseases, the manufacturer of this method has reformulated the anti-TG reagent
to improve its analytical performance. This assay has been standardized against
the WHO international reference standard.
Therefore, reference values of this test will be updated, as follows:
PREVIOUS | NEW |
Negative : Less than 60 IU/mL Version of Test: 11 | Negative : Less than 1.3 IU/mL Presence of autoimmune thyroid disease: Greater or equal to 4.5 IU/mL Version of Test: 12 |
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