Benzociadepines Toxicity leves

Reference values Modification

Effective update from 28/06/2022

*Schulz et al. Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Critical Care 2012 16:R136.

Test code	Nemonic code	Description	Previous	New
2349	ALPR	ALPRAZOLAM (TRANKIMAZIN), SERUM	Therapeutic level: 5 - 50 µg/L Toxicity: Higher than 100 µg/L Limit of quantification: 2 µg/L	Therapeutic level: 5 - 50 µg/L Toxicity: 100 - 400  µg/L Limit of quantification: 2 µg/L
1737	BRO	BROMAZEPAM, SERUM	Therapeutic level: 50-200 µg/L  Toxicity: Higher than 300 µg/L  (Higher than 2000 µg/L Lethal) Limit of quantification: 10 µg/L	Therapeutic level: 50-200 µg/L  Toxicity:  300 - 400  µg/L  (Higher than 2000 µg/L Lethal) Limit of quantification: 10 µg/L
745	DIA	DIAZEPAM (VALIUM), SERUM	Therapeutic level: 100 - 2500 µg/L  Toxicity: Higher than 3000 µg/L Limit of quantification: 25 µg/L	Therapeutic level: 100 - 2500 µg/L  Toxicity: 3000 - 5000 µg/L Limit of quantification: 25 µg/L
5112	FLURO	Flurazepam, SERUM	Therapeutic level: 20 - 100 µg/L Toxicity: Higher than 200 µg/L (Higher than 800 µg/L Lethal) Limit of quantification: 3 µg/L	Therapeutic level: 20 - 100 µg/L Toxicity: 200 - 500  µg/L (Higher than 800 µg/L Lethal) Limit of quantification: 3 µg/L
835	LORA	LORAZEPAM, SERUM	Therapeutic level: 20 - 250 µg/L Toxicity: Higher than 300 µg/L Limit of quantification: 5 µg/L	Therapeutic level: 20 - 250 µg/L Toxicity: 300 -500 µg/L Limit of quantification: 5 µg/L
1575	NITRZ	NITRAZEPAM, SERUM	Therapeutic level: 30 - 100 µg/L Toxicity: 200 µg/L Limit of quantification: 20 µg/L	Therapeutic level: 30 - 100 µg/L Toxicity: 200 - 300 µg/L Limit of quantification: 20 µg/L
8671	OXAZ	OXAZEPAM, SERUM	Therapeutic level: 200-1500 µg/L   Limit of quantification: 25 µg/L	Therapeutic level: 200 - 1500 µg/L Toxicity: 2000 µg/L (3000 - 5000 µg/L Lethal) Limit of quantification: 25 µg/L
1301	ZOLPID	ZOLPIDEM, SERUM	80 - 150 µg/L LOQ: 12 µg/L	80 - 150  µg/L Toxicity: 500 µg/L Limit of quantification: 12 µg/L