Wednesday, July 13, 2022

Isocyanates (metabolites: HDA, 2,4-TDA, 2,6-TDA and MDA), urine

Reference values and Delivery Time Modification

Test code: 3429
Nemonic code: ITCO

Effective update from 15/07/2022




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Reference values:

People exposed to HDI (hexamethylene diisocyanate 1,6)
      Indicative biological limit value at the end of the workday
     
      HDA (1,6-hexamethylene diamine): 17.5 to 52.6 µg/g creatinine
     
      People exposed to TDI (toluene diisocyanate)
      Indicative biological limit value at the end of the workday
     
      2,4-TDA (toluene diamine-2,4): 2.8 to 9.6 µg/L
      2,6-TDA (toluene diamine-2,6): 5.6 to 16.6 µg/L
     
      People exposed to MDI (4,4-methylene diphenylisocyanate)
      biological limit value (BLW-DFG) at the end of the workday
     
      MDA (4,4-methylene dianiline): 10.0 µg/L
     
      Amines are analyzed metabolites appear in the urine of people exposed to the corresponding diisocyanate (HDI, TDI, MDI).
     
      The relationship between urinary concentration of HDA and TDA and health effects is not established, so these values are only useful as indicators of level of exposure.
     

     
      Delivery term: 23 days
     
     
      Version of Test: 5
     

Reference values:

People exposed to HDI (hexamethylene diisocyanate 1,6)
      Indicative biological limit value at the end of the workday
     
      HDA (1,6-hexamethylene diamine): 17.5 to 52.6 µg/g creatinine
     
      People exposed to TDI (toluene diisocyanate)
      Indicative biological limit value at the end of the workday
     
      2,4-TDA (toluene diamine-2,4): Less than 9.6 µg/L
      2,6-TDA (toluene diamine-2,6): Less than 16.6 µg/L

     
      People exposed to MDI (4,4-methylene diphenylisocyanate)
      biological limit value (BLW-DFG) at the end of the workday
     
      MDA (4,4-methylene dianiline): 10.0 µg/L
     
      Amines are analyzed metabolites appear in the urine of people exposed to the corresponding diisocyanate (HDI, TDI, MDI).
     
      The relationship between urinary concentration of HDA and TDA and health effects is not established, so these values are only useful as indicators of level of exposure.         

         
           
     
      Delivery term: 32 days
     
     
      Version of Test: 6
     


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