Friday, March 2, 2012

MOLECULAR STUDY GEN K-RAS, TISSUE

New Test in CIC Catalog

Test Code: 3787

Sample:
Tumoral tissue
Conservation:
Room temperature
Method:
Sequencing Method
Set Up Days:
Daily
TAT (Days):
20 days
Information:
This gene encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. Tumor frequency of K-RAS mutations: pancreas (80-90%), colon and rectum (25-60%), lung (25-60%), prostate (0-25%), skin (0-25%), thyroid (0-60%), liver (10-25%), ovary (0-50%), endometrium (10-40%), kidney (0-50%), brain (0-15%), testis (seminoma) (10-45%), acute non lymphocytic leukemia and myelodysplasia (5-15%), urinary bladder (5%), head and neck (10%), breast (10%)
Links:

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