THYROGLOBULIN, SERUM

Descriptive update and Reference values Modification

Test code: 412

Effective update from 31/01/2017

PREVIOUS	NEW
Thiroglobulin          3-42 ng/mL	Thiroglobulin Ultra-sensitive     1.59 - 50.03 ng/mL           Functional sensitivity: <0.1 ng/mL

DIHYDROXYPHÉNYLALANINE- DOPA (3,4-DIHYDROXYPHENYLALANINE), PLASMA

Reference values and Delivery Time, Method, Sample and descriptive Modification

Test code: 1296

Effective update from 01/02/2017

PREVIOUS	NEW
Dihydroxyphenylalanine -        DOPA  (3,4 Dihydroxyphenylalanine)             High performance liquid chromatography       Plasma heparine       Without treatment L-DOPA       0.2 - 2.5 mg/L                   Delivery term: 15 days	Levodopa                           Gas Chromatography/Mass Spectrometry           2 ml frozen serum      0.2 - 2.5 mg/L      Delivery term: 17 days

Fetal RhD, maternal whole blood

Fetal Sex and Fetal RHD in Maternal Plasma

Test code: 4446

We remind you that it is essential Informed Consent to perform the determination of Fetal Sex and Fetal RhD in maternal plasma.

Those samples that do not attach this docuemnt will not be processed.

The Document is: MP_RML23-2 Test Requisition Form Petition. Analysis of fetal DNA in maternal plasma

GLUCAGON, plasma

Reference values  Modification

Test code: 356

Effective update from 27/01/2017

PREVIOUS	NEW
Less than 208 pg/mL       * Source: PNT, Insert	25 - 250 pg/mL       * Source: PNT, Insert

Tricyclic antidepressants, serum

Reference values Modification

Test code: 5077

Effective update from 26/01/2017

PREVIOUS	NEW
AMITRIPTYLINE: 50-300 ng/mL (toxic >500 ng/mL)       NORTRIPTYLINE: 50-250 ng/mL (toxic >500 ng/mL)       IMIPRAMINE: 50-150 ng/mL (toxic >400 ng/mL)       DESIPRAMINE: 30-300 ng/mL (toxic >500 ng/mL)       CLOMIPRAMINE: 90-250 ng/mL (toxic >400 ng/mL)	Amitriptyline / nortriptyline:              80-200 µg/L Imipramine / desipramine:        175-300 µg/L Clomipramine:                     20-250 µg/L

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NITRIC OXIDE, SERUM

Method, Sample collection, Reference values and Delivery Time Modification

Test code: 4225

Effective update from 26/01/2017

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Chemiluminiscence          23 - 51 µmol/L       Frozen serum                  Delivery term: 40 days	Enzymeimmunoassay         13 - 97 µmol/L                    Refrigerated serum      Delivery term: 15 days

GLUTATHION PEROXIDASE, WHOLE BLOOD

 Delivery Time Modification

Test code: 3049

Effective update from 31/01/2017

PREVIOUS	NEW
Delivery term: 10 days	Delivery term: 6 days

TRYPSIN, SERUM

Reference values  Modification

Test code: 413

Effective update from 27/01/2017

PREVIOUS	NEW
NORMAL VALUE: 10 - 57 ng/mL       CHRONIC PANCREATITIS: Less than 47 ng/mL       ACUTE PANCREATITIS : 92 - 850 ng/mL       TOTAL PANCREATECTOMY: Less than 1,5 ng/mL       * Fuente: PNT, Insert	140 - 400 ng/mL                                       * Fuente: PNT, Insert

IGFBP-3 (INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN, SERUM

Method Modification

Test code: 2343

Effective update from 20/01/2017

PREVIOUS	NEW
Radioinmunoassay	Chemiluminiscence

FREE INSULIN, PLASMA

Method Modification

Test code: 1528

Effective update from 20/01/2017

PREVIOUS	NEW
Radioinmunoassay	Chemiluminiscence

Prostate Cancer (PCA3) screening, urine

Reference values and Delivery Time Modification

Test code: 1318

Effective update from 20/01/2017

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The PCA3 Score is intended for use in conjunction with standard-of-care diagnostic algorithms as and aid in the diagnosis of prostate cancer. A PCA3 Score greater or equal to 25 indicates an over-expression of PCA3 mRNA with an increased probability of a positive repeat biopsy than a PCA3 Score < 25 and an active surveillance with a prostatic biopsy is appropriate. The PCA3 Score cut-off of 25 provides the optimal balance between sensitivity (64%) and specificity (76%).                   Delivery term: 20 days

The PCA3 gene is a prostate specific gene that shows a significant overexpression in prostatic carcinoma cells (prostate carcinogenic cells express 60 to 100 times more ARNm of PCA3 than normal cells). Progensa test is highly specific for quantifying the expression of PCA3 and PSA ARNm genes in prostate cells. The assessment of PSA ARNm allows estimating the quantity of prostatic cells in the patient sample and is used as an internal control of the sample.  The PCA3 index is calculated by the following formula (PCA3-ARNm/PSA-ARNm)x1000. At higher outcomes, higher is the probability for positivity in prostate cancer. A cutoff value of 35 is taken to report a positive result. This cutoff has the best sensitivity vs. specificity relation (48% vs. 79%). Values under 30 indicate a low probability of prostate cancer being the probability lower at lower values. .                Bibliography:  - Bussemakers MJ et al. Cancer Res 1999;59(23):5975-9. - Groskopf J et al. Clin Chem 2006;52(6):1089-95. - Hessels D et al. Eur Urol 2003;44(1):8-15. - Groskopf J et al. Posterpräsentation EUA 2007. - Haese et al. Posterpräsentation EAU 2007.           Delivery term: 21 days

GABA (B) ANTIRECEPTORS, BIOLOGICAL SAMPLE

Descriptive update, Method and Delivery Time Modification

Test code: 1750

Effective update from 20/01/2017

PREVIOUS	NEW
GABA (B) Antireceptors, Biological sample       Immunohistochemistry                     Delivery term: 15 days	GABA (B) Antireceptors, CSF       IFI                         Delivery term: 8 days

INTERFERON GAMMA (QUANTIFERON TB), PLASMA

 Sample collection Modification

Test code: 3147

Effective update from 16/01/2017

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Three tubes:   - Grey tube (control)   - Red tube (TB antigens)  - Purple tube (mitogen)

Sample tubes: Test-specific tubes that contain test- specific reagents. 4 tubes are needed:       Quantiferon TB1: green cap      Quantiferon TB2: yellow cap      Quantiferon Nil: grey cap      Quantiferon Mitogen: purple cap Tubes must be kept at room temperature (between 4 and 25ºC). Gently mix the tube content before blood drawing.  1- Collect 1mL of blood by venipuncture directly into each of the 4 blood collection tubes. The black mark on the side of the tubes indicates the 1mL fill volume. Ensure that the correct volume is drawn 2-  Immediately after filling tubes, shake them ten (10) times just firmly enough to ensure the entire inner surface of the tube is coated with blood to solubilize the tube content 3-  Mark or label tubes taking care of not impairing the content visibility 4-  Incubate tubes at 37ºC +/- 1, for 16-24h  5-  Centrifuge at 2.000-3.000 g for 15 min 6-  Gently separate plasma       7-  Test samples or keep plasma (up to 28 days at 2-8ºC or longer periods at temperatures equal or under -20ºC)

METANEPHRINE FRACTIONS , PLASM

Reference values Modification

Test code: 3710

Effective update from 16/01/2017

PREVIOUS	NEW
Metanephrin :   Less than 90 pg/mL       Normetanephrin: Less than 180 pg/mL       * Fuente: PNT, Insert	Metanephrin :   Less than 65  pg/mL   Normetanephrin: Less than 196 pg/mL   * Fuente: PNT, Insert