CAFFEINE, SERUM

Reference values, Conservation of the Sample, and Delivery Time Modification

Test code: 1536

Effective update from 31/07/2017

PREVIOUS	NEW
5- 20 mg/L (LOD and LOQ: 1 mg/L) Premature babies:   - The therapeutic zone comonly admitted is from 5 to 20 mg/L.   - However, concentrations between 15mg/L and 20mg/L show a more favorable efficiency/toxicity ratio  (Gal P.J Pediatr Pharmacol Ther 2007 VOL 12 Nº4).       Sample: Serum (1 mL) Frozen       Delivery term: 6 days	2 - 10 mg/L                                    (Schulz et al. Critical Care 2012, 16:R136 http://ccforum.com/content/16/4/R136)                                       Sample: Serum (1 mL) Refrigerated           Delivery term: 5 days

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Restrictions for samples reception

We inform you that for 15th August festivity, no samples will be accepted for:


NEOBONA ADVANCE PLUS TEST AND HARMONY

We can not receive samples from 11th-15th August, inclusive


MELISA TEST

We can not receive samples from 7th-15th August, inclusive.


AUTOLOGOUS SERUM

We can not receive samples on 15th August

Cocaine confirmation (with chromatogram), urine

Reference values Modification

Test code: 5254

Effective update from 31/07/2017

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Cocaine:       Cut-off: 25 ng/mL       Measuring uncertainty: 5 ng/mL             Benzoilecgnonine:       Cut-off: 25 ng/mL       Measuring uncertainty: 5 ng/mL             In the received sample all of the indicated substances have been analyzed. The following positivity criterion has been used: when the concentration of the substances is over or equal the cut-off value plus the value of test uncertainty, the result is Positive. In opposite case the result is Negative. The laboratory has a measurement uncertainty across the entire working range.

Cocaine:       Quantification limit: 25 ng/mL       Measuring uncertainty: 3,3 ng/mL             Benzoilecgnonine:       Quantification limit: 25 ng/mL       Measuring uncertainty: 3,9 ng/mL             In the received sample all of the indicated substances have been analyzed. The following positivity criterion has been used: when the concentration of the substances is over or equal the quantification limit value plus the value of test uncertainty, the result is Positive. In opposite case the result is Negative. The laboratory has a measurement uncertainty across the entire working range.

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Cocaine (confirmation), urine

Reference values Modification

Test code: 2550

Effective update from 31/07/2017

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Cocaine:       Cut-off: 25 ng/mL       Measuring uncertainty: 5 ng/mL             Benzoilecgnonine:       Cut-off: 25 ng/mL       Measuring uncertainty: 5 ng/mL             In the received sample all of the indicated substances have been analyzed. The following positivity criterion has been used: when the concentration of the substances is over or equal the cut-off value plus the value of test uncertainty, the result is Positive. In opposite case the result is Negative. The laboratory has a measurement uncertainty across the entire working range.

Cocaine:       Quantification limit: 25 ng/mL       Measuring uncertainty: 3,3 ng/mL             Benzoilecgnonine:       Quantification limit: 25 ng/mL       Measuring uncertainty: 3,9 ng/mL             In the received sample all of the indicated substances have been analyzed. The following positivity criterion has been used: when the concentration of the substances is over or equal the quantification limit value plus the value of test uncertainty, the result is Positive. In opposite case the result is Negative. The laboratory has a measurement uncertainty across the entire working range.

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HISTIDINE 3 METHYL, PLASMA

Reference values, Sample and Delivery Time Modification

Test code: 1103

Effective update from 28/07/2017

PREVIOUS	NEW
2 - 9 µmol/L       LOD: <0.01 µmol/L       Sample: Plasma (Lithium Heparin) (1 mL). Frozen.             Delivery term: 10 days	Premature and Adult: Less than 5 µmol/L  Newborns: 5 - 23 µmol/L Sample: Plasma (EDTA) (1 mL). Frozen.                         Delivery term: 17 days

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Familial Hypertrophic Cardiomyopathy, panel (27 genes) NGS, whole blood

Description Modification

Test code: 1247

Effective update from 28/07/2017

PREVIOUS	NEW
Familial Hypertrophic Cardiomyopathy, panel (27 genes) NGS, whole blood       ACTC1, GLA,  MYBPC3, MYH7, MYL2,  MYL3,  PRKAG2, PTPN11, TNNI3, TNNT2, TPM1, ACTN2, AGL, ANKRD1, BRAF, CALR3, CASQ2, CAV3, CRYAB, CSRP3, CTF1, DES, DTNA, FHL1, FXN, GAA, JPH2	Familial Hypertrophic Cardiomyopathy, panel (41 genes) NGS, whole blood           ALPK3, ACTC1, ACTN2, AGL, ANKRD1, BAG3, CALR3, CASQ2, CAV3, COX15, CRYAB, CSRP3, DES, FLNC, GAA, GLA, JPH2, LAMP2, LDB3, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYLK2, MYO6, MYOZ2, MYPN, NEXN, PDLIM3, PLN, PRKAG2, TAZ, TCAP, TNNC1, TNNI3, TNNT2, TPM1, TTN, TTR, VCL

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Dilated Cardiomyopathy, panel (59 genes) NGS, whole blood

Description Modification

Test code: 4735

Effective update from 28/07/2017

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Dilated Cardiomyopathy, panel (59 genes) NGS, whole blood ACTC1, BAG3, DES, DMD, DSP, FLNC, LMNA, MYBPC3, MYH7, PKP2, PLN, RBM20, TAZ, TNNC1, TNNI3, TNNT2, TPM1, TTN, ABCC9, ACTA1, ACTN2, ALMS1, ANKRD1, CAV3, CRYAB, CSRP3, DNAJC19, DOLK, DSC2, DSG2, EMD, EYA4, FHL2, FKRP, FKTN, FOXD4, GAA, GATA4, GATA6, GATAD1, GLB1, HFE, JUP, LAMA2, LAMA4, LAMP2, LDB3, MURC, MYH6, MYL2, MYL3, MYOT, MYPN, NEBL, NEXN, PSEN1, PSEN2, RAF1, RYR2, SCN5A, SGCD, SLC22A5, TBX20, TCAP, TMEM43, TMPO, TTR, TXNRD2, VCL

Dilated Cardiomyopathy, panel (67 genes) NGS, whole blood   ABCC9, ACTC1, ACTN2, ANKRD1, BAG3, CAV3, CSRP3, CRYAB, CTF1, DES, DMD, DNAJC19, DOLK, DSC2, DSG2, DSP, EMD, EYA4, FBXO32, FHL2, FKTN, FKRP, FLNC, FOXD4, GATA4, GATAD1, HCN4, ILK, JUP, LAMA4, LAMP2, LDB3, LMNA, MYBPC3, MYH6, MYH7, MYPN, NEBL, NEXN, PDLIM3, PKP2, PLEKHM2, PLN, PRDM16, PSEN1, PSEN2, RAF1, RBM20, RYR2, SCN5A, SDHA, SGCD, SYNE1, SYNE2, SLC22A5, TAZ, TBX20, TCAP, TMPO, TNNC1, TNNI3, TNNT2, TPM1, TTN, TTR, TXNRD2, VCL

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Dilated Cardiomyopathy, panel (18 genes) sequencing, whole blood

Description Modification

Test code: 3898

Effective update from 28/07/2017

PREVIOUS	NEW
Dilated Cardiomyopathy, panel (18 genes) sequencing, whole blood ACTC1, BAG3, DES, DMD, DSP, FLNC, LMNA, MYBPC3, MYH7, PKP2, PLN, RBM20, TAZ, TNNC1, TNNI3, TNNT2, TPM1, TTN	Dilated Cardiomyopathy, panel (30 genes) sequencing, whole blood ACTC1, ACTN2, ANKRD1, AG3,CSRP3, DES, DMD, DSG2, EYA4, LDB3, LMNA, MYBPC3, MYH6,  MYH7, NEXN, PLN, PSEN1, PSEN2, RBM20, SCN5A, SGCD,TAZ, TCAP,TMPO, TNNC1, TNNI3, TNNT2, TPM1, TTN, VCL

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HISTIDINE 3 METHYL, PLASMA

Erased test

Test code: 1103

Effective update from 28/07/2017

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OPIATES- CONFIRMATION, URINE

Reference values and Delivery Time Modification

Test code: 2543

Effective update from 25/07/2017

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Negative:       Codeine and Morphine: Less than 300 ng/mL. LOD: < 10 ng/mL       6-MAM (6-Monoacetylmorphine): Less than 10 ng/mL.LOD:< 1 ng/mL             EWDTS 2011 (European Workplace Drug Testing Society).                         Delivery term: 12 days

Morphine:     Quantification limit:     25 ng/mL     Measurement uncertainty: 5.4 ng/mL  6-monoacetyl morphine (6AM):     Quantification limit:     10 ng/mL     Measurement uncertainty:   2 ng/mL  Codeine:     Quantification limit:      25 ng/mL     Measurement uncertainty : 4.2 ng/mL                       In the received sample all of the indicated substances have been analyzed. The following positivity criterion has been used: when the concentration of the substances is over or equal the quantification limit value plus the value of test uncertainty, the result is Positive. In opposite case the result is Negative. The laboratory has a measurement uncertainty across the entire working range.     Delivery term: 3 days

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Opiates confirmation (with chromatogram), urine

Reference values and delivery time Modification

Test code: 5256

Effective update from 25/07/2017

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Negative:       Codeine and Morphine: Less than 2000 ng/mL       6-MAM (6-Monoacetylmorphine): Less than 10 ng/mL.       (SAMSHA:The Substance Abuse and Mental Health Services Administration).                   Delivery term: 12 days

Morphine:     Quantification limit:     25 ng/mL     Measurement uncertainty: 5.4 ng/mL  6-monoacetyl morphine (6AM):     Quantification limit:     10 ng/mL     Measurement uncertainty:   2 ng/mL  Codeine:     Quantification limit:      25 ng/mL     Measurement uncertainty : 4.2 ng/mL    In the received sample all of the indicated substances have been analyzed. The following positivity criterion has been used: when the concentration of the substances is over or equal the quantification limit value plus the value of test uncertainty, the result is Positive. In opposite case the result is Negative. The laboratory has a measurement uncertainty across the entire working range.      Delivery term: 3 days

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ETHANOL, URINE

Reference values and Delivery Time Modification

Test code: 905

Effective update from 19/07/2017

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Up to 0.01 g/L       The urine alcohol analysis indicates the presence of ethanol in the body but there is no direct relationship between this value and the blood content. For confirmation of positive values in sobriety checks for drivers is required the ethanol analysis in whole blood.       Bibliography: F.I Prada et al, Annals of the Spanish Royal Society of Chemistry (2003).       * Fuente: Valores Bibliograficos             Delivery term: 3 days

Uncertainty (to 0,05 g/L): 0.01 g/L  Limit of quantification: 0.05 g/L       The urine alcohol analysis indicates the presence of ethanol in the body but there is no direct relationship between this value and the blood content. For confirmation of positive values in sobriety checks for drivers is required the ethanol analysis in whole blood.       Bibliography: F.I Prada et al, Annals of the Spanish Royal Society of Chemistry (2003).       * Fuente: Valores Bibliograficos             Delivery term: 4 days

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