Familial Gastric Cancer (CDH1) NGS, whole blood

Description and Delivery Time Modification

Test code: 1338

Effective update from 04/07/2022

PREVIOUS	NEW
Familial Gastric Cancer (CDH1) NGS, whole blood             Delivery term: 30 days                   Version of Test: 7	FAMILIAL DIFFUSE GASTRIC CANCER · CDH1 · NGS                Delivery term: 32 days                   Version of Test: 8

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IgE SPECIFIC ANTIBODIES FOR FENTANYL (c372), SERUM

Discontinued temporarily

Test code: 9597

Nemomic code: FENTA

Effective update from 29/06/2022

Dear collaborators,

We inform you that, due to problems in the supply of reagent by the supplier, we are forced to  discontinue the determination IgE SPECIFIC ANTIBODIES FOR FENTANYL (c372), SERUM  from today until a new date.

Sorry for the inconvenience caused, we remain at your disposal for any clarification in this regard.

HELICOBACTER PYLORI IgG ANTIBODIES, SERUM

Nemonic code, Method, Reference values and Delivery Time Modification

Test code: 2080

Previous Nemonic code: HPGS

New Nemonic code: HPG

Effective update from 04/07/2022

PREVIOUS	NEW
Method: Enzyme Immunoassay Reference values:   Negative : Less than 8 U/mL Grey Zone : 8 - 12 u/mL Positive : Greater than 12 U/mL       Delivery term: 5 days       Version of Test: 8	Method: Chemiluminescence Reference values:     Negative : Less than 0.79 U/mL Grey Zone : 0.80 - 0.89 u/mL Positive : Greater than 0.90 U/mL       Delivery term: 3 days      Version of Test: 9

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Polyposis Colon Cancer (MUTYH) MLPA, whole blood

Description Modification

Test code: 4885

Effective update from 30/06/2022

PREVIOUS	NEW
Polyposis Colon Cancer (MUTYH) MLPA, whole blood             Version of Test: 1	HEREDITARY POLYPOSIS COLON CANCER · MUTYH · MLPA                Version of Test: 2

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Polyposis Colon Cancer (APC, MUTYH) NGS, total blood

Description and Delivery Time Modification

Test code: 3785

Effective update from 30/06/2022

PREVIOUS	NEW
Polyposis Colon Cancer (APC, MUTYH) NGS, total blood             Delivery term: 32 days                   Version of Test: 7	POLYPOSIS COLORECTAL CANCER · APC, MUTYH · NGS                Delivery term: 42 days                   Version of Test: 8

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Polyposis Colon Cancer (MUTYH) sequencing, total blood

Description and Delivery Time Modification

Test code: 1087

Effective update from 30/06/2022

PREVIOUS	NEW
Polyposis Colon Cancer (MUTYH) sequencing, total blood             Delivery term: 32 days                   Version of Test: 3	HEREDITARY POLYPOSIS COLON CANCER · MUTYH · NGS                Delivery term: 22 days                   Version of Test: 4

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BIOAVAILABLE TESTOSTERONE

Method Modification

Test code: 1530

Effective update from 27/06/2022

PREVIOUS	NEW
Radioimmunoassay                   Version of Test: 10	Calculation                                    Version of Test: 11

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Benzociadepines Toxicity leves

Reference values Modification

Effective update from 28/06/2022

*Schulz et al. Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Critical Care 2012 16:R136.

Test code	Nemonic code	Description	Previous	New
2349	ALPR	ALPRAZOLAM (TRANKIMAZIN), SERUM	Therapeutic level: 5 - 50 µg/L Toxicity: Higher than 100 µg/L Limit of quantification: 2 µg/L	Therapeutic level: 5 - 50 µg/L Toxicity: 100 - 400  µg/L Limit of quantification: 2 µg/L
1737	BRO	BROMAZEPAM, SERUM	Therapeutic level: 50-200 µg/L  Toxicity: Higher than 300 µg/L  (Higher than 2000 µg/L Lethal) Limit of quantification: 10 µg/L	Therapeutic level: 50-200 µg/L  Toxicity:  300 - 400  µg/L  (Higher than 2000 µg/L Lethal) Limit of quantification: 10 µg/L
745	DIA	DIAZEPAM (VALIUM), SERUM	Therapeutic level: 100 - 2500 µg/L  Toxicity: Higher than 3000 µg/L Limit of quantification: 25 µg/L	Therapeutic level: 100 - 2500 µg/L  Toxicity: 3000 - 5000 µg/L Limit of quantification: 25 µg/L
5112	FLURO	Flurazepam, SERUM	Therapeutic level: 20 - 100 µg/L Toxicity: Higher than 200 µg/L (Higher than 800 µg/L Lethal) Limit of quantification: 3 µg/L	Therapeutic level: 20 - 100 µg/L Toxicity: 200 - 500  µg/L (Higher than 800 µg/L Lethal) Limit of quantification: 3 µg/L
835	LORA	LORAZEPAM, SERUM	Therapeutic level: 20 - 250 µg/L Toxicity: Higher than 300 µg/L Limit of quantification: 5 µg/L	Therapeutic level: 20 - 250 µg/L Toxicity: 300 -500 µg/L Limit of quantification: 5 µg/L
1575	NITRZ	NITRAZEPAM, SERUM	Therapeutic level: 30 - 100 µg/L Toxicity: 200 µg/L Limit of quantification: 20 µg/L	Therapeutic level: 30 - 100 µg/L Toxicity: 200 - 300 µg/L Limit of quantification: 20 µg/L
8671	OXAZ	OXAZEPAM, SERUM	Therapeutic level: 200-1500 µg/L   Limit of quantification: 25 µg/L	Therapeutic level: 200 - 1500 µg/L Toxicity: 2000 µg/L (3000 - 5000 µg/L Lethal) Limit of quantification: 25 µg/L
1301	ZOLPID	ZOLPIDEM, SERUM	80 - 150 µg/L LOQ: 12 µg/L	80 - 150  µg/L Toxicity: 500 µg/L Limit of quantification: 12 µg/L

TESTOSTERONE, SERUM

Reference values Modification

Test code: 244

Effective update from 27/06/2022

PREVIOUS

NEW

Men:       Less than 1 year old: 0.087 - 2.99 ng/mL       1 - 8 years old: Less than 0.36 ng/mL       9 - 15 years old: Less than 6.32 ng/mL       16 - 20 years old: 1.48 - 7.94 ng/mL       21 - 49 years odl: 2.40 - 8.70 ng/mL       Greater than or equal to 50 years old: 2.21- 7.16 ng/mL             Women:       Less than 1 year old: Less than 0.62 ng/mL       1 - 8 years old: Less than 0.62 ng/mL       9 - 15 years old: Less than 0.44 ng/mL       16 - 20 years old: 0.14 - 0.49 ng/mL       21 - 49 years old: 0.14 - 0.53 ng/mL       Grater than or equal to 50 years old: 0.12 - 0.36 ng/mL             Reference values depending on the Tanner Stages (pubertal age):       Men:       I : 0.02 - 0.23 ng/mL       II : 0.05 - 0.70 ng/mL       III: 0.15 - 2.80 ng/mL       IV : 1.05 - 5.45 ng/mL       V : 0.65 - 8.00 ng/mL       Women:       I : 0.02 - 0.10 ng/mL       II : 0.05 - 0.30 ng/mL       III: 0.10 - 0.30 ng/mL       IV : 0.15 - 0.40 ng/mL       V : 0.10 - 0.40 ng/       * Fuente: PNT, Insert             Version of Test: 9

Men:       Less than 1 year old: 0.087 - 2.99 ng/mL       1 - 8 years old: Less than 0.36 ng/mL       9 - 15 years old: Less than 6.32 ng/mL       16 - 20 years old: 1.48 - 7.94 ng/mL       21 - 49 years odl: 2.40 - 8.70 ng/mL       Greater than or equal to 50 years old: 2.21- 7.16 ng/mL             Women:       Less than 1 year old: Less than 0.62 ng/mL       1 - 8 years old: Less than 0.62 ng/mL       9 - 15 years old: Less than 0.44 ng/mL       16 - 20 years old: 0.14 - 0.49 ng/mL       21 - 49 years old: 0.14 - 0.53 ng/mL       Grater than or equal to 50 years old: 0.12 - 0.36 ng/mL             Reference values depending on the Tanner Stages (pubertal age):       Men:       I : Less or equal than 0.30 ng/mL       II : Less or equal than 2.78 ng/mL       III: 0.09 - 6.55 ng/mL       IV : 0.20 - 7.54 ng/mL       V : 0.17 - 9.02 ng/mL       Women:       I : Less or equal than 0.32 ng/mL       II : 0.05 - 0.22 ng/mL       III: 0.07 - 0.41 ng/mL       IV : 0.15 - 0.54 ng/mL       V : 0.17 - 0.99 ng/mL       * Fuente: PNT, Insert                       Version of Test: 10

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FLUNITRAZEPAM (ROHYPNOL) , SERUM

Reference values Modification

Test code: 2006

Nemonic code: FLUNS

Effective update from 28/06/2022

PREVIOUS	NEW
Therapeuric levels: 6 - 15 µg/L       Toxic levels : > 50 µg/L       LOD/LOQ: 5 µg/L                   Version of Test: 6	Therapeuric levels: 5 - 15 µg/L      Toxic levels : Higher than 50 µg/L      LOQ: 2 µg/L              *AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011, Pharmacopsychiatry 2011, 44, 195-235.            Version of Test: 7

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CLOZAPINE, SERUM

Reference values Modification

Test code: 2890

Nemonic code: CLOZ

Effective update from 28/06/2022

PREVIOUS	NEW
300-800 µg/L             Toxicity: >800 µg/L                   Version of Test: 10	300 - 600 µg/L             Toxicity: Higher than 600 µg/L          *Schulz M., Schmoldt A. Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Pharmazie. 2003 Jul;58(7):447-74.                    Version of Test: 11

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DOXEPINE, SERUM

Reference values Modification

Test code: 2008

Nemonic code: DOXE

Effective update from 28/06/2022

PREVIOUS	NEW
Therapeutic level: 50 - 250 ng/mL       Toxic level: > 400 ng/mL             *Both result and normal values include       DOXEPIN and its metabolit n-DESMETHYLDOXEPIN.             * F.E.Krapf, W.P. Bieger, F.W. Tiller: LaborDatenBuch (1995) Urban & Schwarzenberg, München.                   Version of Test: 3	Therapeutic level: 10 - 200 µg/L       Toxic level: Superior to 500 µg/L                          * Schulz M., Schmoldt A. Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics. Pharmazie. 2003 Jul;58(7):447-74.                           Version of Test: 4

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