Isocyanates (metabolites: HDA, 2,4-TDA, 2,6-TDA and MDA), urine

Result Format, Units and Reference values Modification

Test code: 3429

Nemonic code: ITCO

The new units and reference values are indicated in bold text.

Effective update from 05/10/2022

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Result format: R1:HDA (1,6-hexamethylene diamine): (µg/g creatinine) R2: 2,4-TDA (toluene diamine-2,4): (µg/L) R3:   2,6-TDA (toluene diamine-2,6) (µg/L)  R4: MDA (4,4-methylene dianiline)  (µg/L)   Reference values: People exposed to HDI (hexamethylene diisocyanate 1,6) Indicative biological limit value at the end of the workday       HDA (1,6-hexamethylene diamine): 17.5 to 52.6 µg/g creatinine       People exposed to TDI (toluene diisocyanate) Indicative biological limit value at the end of the workday       2,4-TDA (toluene diamine-2,4): Less than 9.6 µg/L 2,6-TDA (toluene diamine-2,6): Less than 16.6 µg/L       People exposed to MDI (4,4-methylene diphenylisocyanate)biological limit value (BLW-DFG) at the end of the workday       MDA (4,4-methylene dianiline): 10.0 µg/L       Amines are analyzed metabolites appear in the urine of people exposed to the corresponding diisocyanate (HDI, TDI, MDI).       The relationship between urinary concentration of HDA and TDA and health effects is not established, so these values are only useful as indicators of level of exposure.              Version of Test: 8

Result format: R1:HDA (1,6-hexamethylene diamine): (µg/g creatinine) R2: Sum of  2,4-TDA (toluene diamine-2,4) and  2,6-TDA (toluene diamine-2,6) (µg/g creatinine)  R3: MDA (4,4-methylene dianiline)  (µg/L)   Reference values: People exposed to HDI (hexamethylene diisocyanate 1,6) Indicative biological limit value at the end of the workday       HDA (1,6-hexamethylene diamine): 15.0 µg/g creatinine       People exposed to TDI (toluene diisocyanate) Indicative biological limit value at the end of the workday        Sum of 2,4-TDA (toluene diamine-2,4)and 2,6-TDA (toluene diamine-2,6): Less than 5.0 µg/g creatinine       People exposed to MDI (4,4-methylene diphenylisocyanate)biological limit value (BLW-DFG) at the end of the workday       MDA (4,4-methylene dianiline): 10.0 µg/L       Amines are analyzed metabolites appear in the urine of people exposed to the corresponding diisocyanate (HDI, TDI, MDI).       The relationship between urinary concentration of HDA and TDA and health effects is not established, so these values are only useful as indicators of level of exposure.                                                Version of Test: 9

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