Test code: 983
Nemonic code: CLNC
Effective update from 03/07/2023
Effective update from 03/07/2023
PREVIOUS | NEW |
Clobazam: Therapeutic level: 30 - 300 µg/L Toxicity: Greater than 500 µg/L Limit of quantification: 10 µg/L Norclobazam: Therapeutic level: 300 - 3000 µg/L Limit of quantification: 50 µg/L Ratio Norclobazam/Clobazam: Less than 10 NOTE: Norclobazam / Clobazam ratio is useful for obtaining information on drug metabolization capacity and improve dose adjustment. Very high ratios (> 25) indicate that the patient is a slow metabolizer of the CYP2C19 (if you are not taking CYP3A-inducing drugs or CYP2C19 inhibitors). Note: The presence of Norclobazam should be assessed only in the case of therapy without Clonazepam, since it interferes in the analysis. Sample: Room Temperature: 2 weeks Refrigerated: 2 weeks Frozen: 2 months Version of Test: 13 | Clobazam: Therapeutic level: 30 - 300 µg/L Toxicity: Greater than 500 µg/L Limit of quantification: 10 µg/L Norclobazam: Therapeutic level: 300 - 3000 µg/L Toxicity: Greater than 5000 µg/L Limit of quantification: 50 µg/L Ratio Norclobazam/Clobazam: Less than 10 NOTE: Norclobazam / Clobazam ratio is useful for obtaining information on drug metabolization capacity and improve dose adjustment. Very high ratios (> 25) indicate that the patient is a slow metabolizer of the CYP2C19 (if you are not taking CYP3A-inducing drugs or CYP2C19 inhibitors). Note: The presence of Norclobazam should be assessed only in the case of therapy without Clonazepam, since it interferes in the analysis. * Source: M. Schulz, A. Schmoldt, H. Andresen-Streichert, S.
Iwersen-Bergmann. Revisited: Therapeutic and toxic blood concentrations of more
than 1,100 drugs and other xenobiotics. Critical Care 2020 Sample: Refrigerated: 1 week Frozen: 3 months Version of Test: 14 |
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