AMITRIPTYLINE / NORTRIPTYLINE, SERUM

Reference values Modification

Test code: 281

Mnemonic code: QAMN

Effective update from 17/07/2023

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Therapeutic range: 80-200 µg/L Toxicity : >500 µg/L          Note: Amitriptyline is partially metabolised in nortriptyline, the sum of both being useful in therapeutic control. The therapeutic values that are indicated, refer to the aforementioned sum.        * Source: PNT, Insert       Version of Test: 13

Therapeutic level: (Amitriptyline + Nortriptyline):  80 - 200 µg/L Toxicity(Amitriptyline + Nortriptyline): Greater than 300 µg/L LoQ(Amitriptyline): 6 µg/L LoQ(Nortriptylilne): 3 µg/L          *Source: M. Schulz, A. Schmoldt, H. Andresen-Streichert, S. Iwersen-Bergmann. Revisited: Therapeutic and toxic blood concentrations of more than 1.100 drugs and other xenobiotics. Critical Care 2020                                   Version of Test: 14

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