Thursday, July 6, 2023

OXCARBAZEPINE + 10-OH CARBAZEPINE, SERUM

Reference values, Method and Delivery Time Modification

Test code: 7630
Mnemonic code: QOXC

Effective update from 17/07/2023




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10-Hydroxycarbazepine : 5 - 30 mg/L
Oxcarbazepine : 0.4 - 2 mg/L
      
LoQ 10-Hydroxycarbazepine: 1.0 mg/L
LoQ Oxcarbazepine : 0.08 mg/L

*NOTE: Oxcarbazepine is rapidly eliminated from serum, with an apparent half-life of 1.3 to 2.3 hours.

* Source: PNT, Insert





Method: Liquid Chromatography/Triple Quadrupole Mass Spectrometry
     
Delivery term: 6 days
     
     
Version of Test: 21
     


Therapeutic level:        
10-Hydroxycarbazepine: 5 - 30 mg/L
Oxcarbazepine: 0.4 - 2 mg/L

Toxicity (10-Hydroxycarbazepine + Oxcarbazepine): Greater than 40 mg/L   
      
LoQ 10-Hydroxycarbazepine: 1.0 mg/L
LoQ Oxcarbazepine : 0.08 mg/L

*NOTE: Oxcarbazepine is rapidly eliminated from serum, with an apparent half-life of 1.3 to 2.3 hours.         
         
* Source(Therapeutic level): PNT, Insert
**Source (Toxicity): Hiemke C et al. Consensus Guidelines for Therapeutic drug monitoring Pharmacopsychiatry 2018; 51: 9–62. AGNP 2018.

Method: Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS)         
         
         
Delivery term: 5 days
     
     
Version of Test: 22
     


   Find the record of the test by clicking here

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