ENTERO VIRUS (COXSACKIE A9) IgG ANTIBODIES, SERUM

Test reactivation, Description and Reference values Modification

Test code: 2672

Mnemonic code: COXAG

Effective update from 08/07/2024

PREVIOUS	NEW
Description: ENTERO VIRUS (COXSACKIE A9) IgG ANTIBODIES, SERUM Reference values: NEGATIVE: Titer less than 1/40 * Source: PNT, Insert       Version of Test: 10	Description: COXSACKIE A (A7- A9- A16- A24 serotypes) IgG ANTIBODIES, SERUM Reference values: NEGATIVE: Titer less than 1/100 * Source: PNT, Insert       Version of Test: 11

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ENTERO VIRUS (COXSACKIE A9) IgM ANTIBODIES, SERUM

Test reactivation, Description  Modification

Test code: 2671

Mnemonic: COXM

Effective update from 08/07/2024

PREVIOUS	NEW
Description:  ENTERO VIRUS (COXSACKIE A9) IgM ANTIBODIES, SERUM       Version of Test: 9	Description:  COXSACKIE A (A7- A9- A16- A24 serotypes) IgM ANTIBODIES , SERUM       Version of Test: 10

ENTERO VIRUS (COXSACKIE B1-6) IgM ANTIBODIES, SERUM

Test reactivation and Description Modification

Test code: 2047

Nnemonic code: COXBC

Effective update from 08/07/2024

PREVIOUS	NEW
Description:  ENTERO VIRUS (COXSACKIE B1-6) IgM ANTIBODIES, SERUM                    Version of Test: 12	Description: COXSACKIE B (1-6 serotypes) IgM ANTIBODIES, SERUM                                Version of Test: 13

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ENTERO VIRUS (COXSACKIE B1-6) IgG ANTIBODIES, SERUM

Test reactivation, Description and Reference values Modification

Test code: 2048

Mnemonic code: COXG

Effective update from 08/07/2024

PREVIOUS	NEW
Description:   ENTERO VIRUS (COXSACKIE B1-6) IgG ANTIBODIES, SERUM Reference Values:  NEGATIVE: Titer less than 1/40 * Fuente: PNT, Insert       Version of Test: 10	Description:   COXSACKIE B (1-6 serotypes) IgG ANTIBODIES, SERUM Reference Values:  NEGATIVE: Titer less than 1/100 * Fuente: PNT, Insert       Version of Test: 11

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Coxsackie A9 antibodies IgG e IgM, serum

Test reactivation, Description and Reference values Modification

Test code: 4861

Mnemonic code: Does not apply

Effective update from 08/07/2024

PREVIOUS	NEW
Description:  Coxsackie A9 antibodies IgG e IgM, serum Reference values:       Cosackie A9 IgG:  NEGATIVE: Titer less than 1/40 Coxsakie A9 IgM:  NEGATIVE: Títer less than 1/10             Version of Test: 12	Description:                COXSACKIE A (A7- A9- A16- A24 SEROTYPES) IgG and IgM ANTIBODIES), SERUM          Reference values: Cosackie A IgG:  NEGATIVE: Titer less than 1/100 Coxsakie A IgM:  NEGATIVE: Títer less than 1/10         Version of Test: 13

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CORTICOSTERONE - COMPOUND B

Sample conservation Modification

Test code: 1302

Mnemonic: CTCSTB

Effective update from 01/07/2024

PREVIOUS	NEW
Refrigerated serum	Frozen serum

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MERCURY, URINE

Reference values Modification

Test code: 382

Effective update from 08/07/2024

PREVIOUS	NEW
Exposure to elemental mercury and inorganic compounds.       VLB (INSHT 2023): Less than 30 µg/g creatinine.       LoQ: 5 µg/L       VLB (ACGIH 2023): Less than 20 µg/g creatinine             * Fuente: Valores Bibliograficos             Version of Test: 19	Exposure to elemental mercury and inorganic compounds   VLB (INSHT) in urine at the start of the working day: Below 30 µg/g creatinine   Exposure to elemental mercury BEI (ACGIH) in urine at the    start of the working day: Below 20 µg/g creatinine             Version of Test: 20

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INCONTINENTIA PIGMENTI · IKBKG · PCR

New Test in NOÛS Catalog

Test Code: 10071

Sample:	Whole blood - EDTA (5 ml)
Conservation:	Refrigerated
Method:	Long Range PCR
Set Up Days:	Daily
Delivery term:	24 days
Information:
Incontinentia pigmenti (IP) is a disorder that affects the skin, hair, teeth, nails, eyes and the central nervous system. Characteristic skin lesions evolve through four stages: 1) blisters (from birth to the age of around four months); 2) an eruption similar to warts (during several months); 3) swirling macular hyperpigmentation (age around six months to adulthood), and 4) linear hypopigmentation. \nThe diagnosis of IP is based on clinical findings and molecular genetic tests of IKBKG (formerly NEMO), the only gene known to be associated with IP. A deletion that eliminates the exons 4 through 10 of IKBKG is present in approximately 80% of the affected individuals. IP is inherited in X-linked form. IP is a lethal embryonic disease that affects many gestations in which the foetal sex is masculine. Affected males that survive can have karyotype 47, XXY or somatic mosaicism due to the common IKBKG deletion. A female with IP may have inherited the IKBKG mutation from the mother or have a de novo mutation. The parents can be clinically affected or be unaffected, but have germline mosaicism. Affected women have a 50% chance of transmitting the mutant IKBKG allele at conception; however, male conceptuses with a loss-of-function mutation of IKBKG miscarry. Thus, the expected ratio among children born live is approximately 33% unaffected females, 33% affected females, and 33% unaffected males. Prenatal testing for high-risk pregnancies is possible if the disease-causing mutation in the family has been identified.

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Adenovirus antibodies IgA, serum

Erased Test

Test code: 5089
Mnemonic code: ADEA

Effective update from 26/06/2024

Erased test due to discontinuation of the reagent manufacturing.

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CHROMOSOME 8 · FGFR1 (8p12) · FISH

Description Modification

Test code: 3852
Mnemonic code: G13026

Effective update from 08/07/2024

PREVIOUS	NEW
CHROMOSOME 8 · FGFR1 (8p12) · FISH             Version of Test: 5	CHROMOSOME 8 · FGFR1 (8p11) · FISH                Version of Test: 6

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NICKEL, URINE

Clarifications on Changes in Reference Values for Nickel in Urine

According to the new occupational regulations there is an update regarding the units of biological limit values for nickel.

Until now, the exposure index has been reported based on the calculation of nickel concentration with creatinine in urine (code 550 - NIQO), following the structure below:

Creatinine in urine at end of workday                       g/L

Nickel in urine at end of workday (concentration)     µg/L

Nickel in urine at end of workday                              µg/g

According to the ACGIH - American Conference of Governmental Industrial Hygienists, the biological exposure index for nickel in urine at the end of the workday is expressed in units of concentration, without considering the calculation with creatinine, as follows:

Nickel in urine at end of workday µg/L 

Exposure to elemental nickel and insoluble nickel compounds BEI (ACGIH) in urine at end of workweek: Less than 5 µg/L 

Exposure to soluble nickel compounds BEI (ACGIH) in urine at end of workweek: Less than 30 µg/L

Consequently, only the concentration value of nickel analyzed will be reported.

Mnemonic code, Results format and Reference values Modification

Test code: 550

Previous mnemonic code: NIQO

New mnemonic code: NIOC

Effective update from 01/07/2024

PREVIOUS	NEW
Results format:  R1 µg/g creatinine   R2 µg/L                 B.E.I. (ACGIH 2022): after exposure to elemental Nickel and insoluble compounds: 5 µg/L       B.E.I. (ACGIH 2022): after exposure to soluble compounds: 30 µg/L       *B.E.I. - Biological Exposure Index.       * Fuente: Valores Bibliograficos             Version of Test: 14	Results format:  R1 µg/L                      Reference values: Exposure to elemental nickel and insoluble nickel compounds: BEI (ACGIH) in urine at end of workweek: Less than 5 µg/L Exposure to soluble nickel compounds: BEI (ACGIH) in urine at end of workweek: Less than 30 µg/L Limit of quantification: 2 µg/L                Version of Test: 15

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LEAD (PB), URINE

Clarifications on Changes in Reference Values for Lead in Urine

According to the new occupational regulations there is an update regarding the units of biological limit values for lead.

Until now, the exposure index has been reported based on the calculation of lead concentration with creatinine in urine (code 882 - PBOR), following the structure below:

Creatinine in urine at end of workday                   g/L 

Lead in urine at end of workday (concentration) µg/L 

Lead in urine at end of workday                          µg/g

According to the List of MAK and BAT Values, the Permanent Senate Commission of the DFG for the Investigation of Health Hazards of Chemical Compounds in the Work Area, the biological tolerance value for chemical agents (BAT) for lead in urine at the end of the workday is expressed in units of concentration, without considering the calculation with creatinine, as follows:

Lead in urine at end of workday (concentration) µg/L 

Exposure to Tetraethyl and Tetramethyl Lead BAT (DFG) in urine at end of workday: Less than 50 µg/L

Consequently, we will only report concentration value of lead.

Results format and mnemonic code Modification

Test code: 882

Previous mnemonic code: PBOR

New mnemonic code: PBOC

Effective update from 01/07/2024

PREVIOUS	NEW
Results format:       R1 µg/g creatinine       R2 µg/L             Version of Test: 14	Results format:       R1 µg/g creatinine       R2 µg/L             Version of Test: 15

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CHROMIUM, START WORKING DAY URINE

Erased test
CHROMIUM, START DAY URINE

Test code: 8505
Mnemonic code: CROITC

Effective update from 01/07/2024

Alternative: 298 (CRO) - CHROMIUM, END WORKING DAY URINE

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CHROMIUM, END WORKING DAY URINE

Clarifications on Changes in Reference Values for Chromium in Urine

The biological limit value and the timing of sample collection for chromium in urine has chenged at the current occupational regulation. Until now, the exposure index has been reported as an increase in concentration between the beginning of the workday urine sample (code 8505 – CROITC) and the end of the workday urine sample at the end of the workweek (code 298 – CRO), with the following structure and limit values:

Chromium in urine (start of workday) µg/L 

Chromium in urine (end of workday) µg/L 

VLB (INSHT 2023) End of workweek For Chromium (VI), water-soluble fumes: 25.0 µg/L 

Workday Increment: 10.0 µg/L

According to the guide "Professional Exposure Limits for Chemical Agents in Spain - INSST (2024)," the biological limit value for chromium in urine at the end of the workday is indicated by a single sample taken at the end of the workweek, with the following value:

Chromium in urine at the end of the workday µg/L 

Exposure to Chromium (VI) compounds: BLV (INSST) in urine at the end of the workweek: Less than 7.5 µg/L

Consequently, the determination of chromium in urine at the start of the workday (8505 – CROITC) will be permanently discontinued, and only the concentration value of chromium in urine at the end of the workday (298 – CRO) will be reported.

Erased test
CHROMIUM, START DAY URINE

Test code: 8505
Mnemonic code: CROITC

Effective update from 01/07/2024

Alternative: 298 (CRO) - CHROMIUM, END WORKING DAY URINE

Reference value modification
CHROMIUM, END WORKING DAY URINE

Test code: 298
Mnemonic code: CRO

Effective update from 01/07/2024

PREVIOUS	NEW
V.L.B (INSHT 2023) End of working week:       For Chromium (VI), water soluble fumes: 25.0 µg/L       Workday increase: 10.0 µg/L       LoQ: 0.8 µg/L             * The value refers to the difference of the results of the samples taken at the end and at the beginning of the working day                   Version of Test: 11	Exposure to Chromium (VI) compounds:  BLV (INSST) in urine at the end of the workweek: Less than 7.5 µg/L Limit of quantification: 0.8 µg/L                                                 Version of Test: 12

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